Modern Healthspan

Here Prof Kaeberlein talks about the million molecule challenge and why he thought that it was necessary. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been recognized by several prestigious awards, and has...

Here Prof Kaeberlein talks about the Dog Aging Project a study which is following 100,000's of dogs to understand aging better and includes a RTC of rapamycin related to lifespan. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200...

Here Prof Kaeberlein talks about the recent paper on taurine deficiency as a driver of aging and makes some comparisons between taurine and rapamycin. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scientific papers, has been reco...

Here Prof Kaeberlein provides some updates on rapamycin, in particular the results from the survey based trial that his team ran and thoughts on next steps for the supplement. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life. He has published more than 200 scienti...

Here we discuss how to measure your gut microbiome, what the future of probiotic and gut microbiome research may hold and what Dr Cutcliffe's personal regimen is. 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals, and biotechnology. Prior to...

Metabolic Daily is a less potent but more available form of the Glucose Control probiotic used in the clinical trial. Dr Colleen Cutcliffe discusses the differences in the formulations, the best time to take and what effects people have seen 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managi...

We talk to Dr Colleen Cutcliffe about a clinical trial that they ran with 5 strains of probiotic. We also talk about whether the strains remained resident and what are the best prebiotics for akkermansia. 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmac...

We talk to Dr Colleen Cutcliffe about akkermansia muciniphila a probiotic that is involved in Some links are affiliate links so we will earn a commission when they are used to purchase products. 🌐Links in this video Colleen Cutcliffe is the Chief Executive Officer and co-founder of Pendulum. She has more than 15 years of experience leading and managing biology teams in academia, pharmaceuticals,...

This is a bonus extra where we asked Dr Baur for his view on the recent taurine longevity paper as he had written a perspective piece in the same publication - Taurine linked with healthy aging ⁠https://www.science.org/doi/10.1126/science.adi3025⁠ 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube 10% Discount on Renue By Science products with code MH...

We talk to Dr Joseph Baur about NMNH and NRH and some of the ways that his lab is working on optimizing NAD boosters by trying to get more of the NAD into the mitochondria and testing on larger animals and in humans. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products...

We talk to Dr Joseph Baur about how the NAD precursors are absorbed when administered in different formats and what is seen in the biochemistry after that. And some really weird interaction between mammals and bacteria with nicotinamide/nicotinic acid in the gut. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealt...

We talk to Dr Joseph Baur about results from trials of NAD boosters in mice and human trials and possible reasons for why the positive results in mice have not translated to humans. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscien...

We talk to Dr Joseph Baur about how NAD metabolism changes with age, especially the role of NAMPT, the consuming enzymes and NAD boosters. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ Use SUBMHS for 15% on subscriptions...

We talk to Dr Joseph Baur about the evidence of NAD decline with age and how it can be restored with exercise. We also touch on NAD/NADH ratio. Some links are affiliate links so we will earn a commission when they are used to purchase products. 🌐Links in this video The Baur Lab website https://www.med.upenn.edu/baurlab/ Catch us on YouTube: https://www.youtube.com/c/modernhealthspan 10% Discount...

We talk to Dr Vijay Yadav about his planned next steps for interventional human trials and what doses he will try. Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mous...

We talk to Dr Vijay Yadav about the human results from the trial and how the dosage might translate into humans. Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mouse...

We talk to Dr Vijay Yadav about some of the results in terms of lifespan and healthspan from the recent paper that he was the main author on. Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of...

We talk to Dr Vijay Yadav about taurine, why he started studying it, some of the history and how it varies with age. Dr Yadav leads the Systems Biology of Aging Laboratory, which aims to identify novel functional connections between organs and to unravel factors that underlie human metabolism and its disorders. The lab's expertise is in the development of a variety of technologies including mo...

In this episode Dr Yurth talks about her longevity protocol, including her use of a CGM and protein requirements. Dr Elizabeth Yurth is Co-Founder and Chief Medical Officer of Boulder Longevity Institute. Along with her 30 years as a practicing orthopedist specializing in sports medicine, Dr. Yurth has made it her mission to share the latest scientific research on how to truly heal the body at the...

In this video Dr Yurth introduces spermidine as an autophagy activator and talks about the regimen she uses while focusing on muscle maintenance and growth. Dr Elizabeth Yurth is Co-Founder and Chief Medical Officer of Boulder Longevity Institute. Along with her 30 years as a practicing orthopedist specializing in sports medicine, Dr. Yurth has made it her mission to share the latest scientific re...

In this video Dr Yurth introduces what peptides are and talks about some of the most important ones for longevity and how they work. Dr Elizabeth Yurth is Co-Founder and Chief Medical Officer of Boulder Longevity Institute. Along with her 30 years as a practicing orthopedist specializing in sports medicine, Dr. Yurth has made it her mission to share the latest scientific research on how to truly h...

In this episode Dr Yurth talks about why she set up the Boulder Longevity Institute and the key metrics that she looks for to determine a persons true health Dr Elizabeth Yurth is Co-Founder and Chief Medical Officer of Boulder Longevity Institute. Along with her 30 years as a practicing orthopedist specializing in sports medicine, Dr. Yurth has made it her mission to share the latest scientific r...

In this episode Dr Newport talks about some of the do's and don'ts to minimize the risk of getting Alzheimer's. In this video Dr Bohr discusses his experience with NR, NMN and Urolithin A, using NAD boosters in people and the importance of measuring not only NAD but also its metabolites. And the impact of NR supplementation on the gut microbiome. Dr. Vilhelm Bohr is a molecular biologi...

In this episode Dr Bohr talks about NR's impact on age related loss of hearing and smell in mice Dr. Vilhelm Bohr is a molecular biologist who is currently an affiliate professor at the University of Copenhagen. He is also a former chief of the Laboratory of Molecular Genetics at the National Institute on Aging (NIA). Dr. Bohr's research interests focus on DNA repair, mitochondrial biology...

In this episode Dr Bohr talks about his work with Alzheimer's using Nicotinamide Riboside (NR) and how this impacts DNA repair, mitophagy, senescence and inflammation. Dr. Vilhelm Bohr is a molecular biologist who is currently an affiliate professor at the University of Copenhagen. He is also a former chief of the Laboratory of Molecular Genetics at the National Institute on Aging (NIA). Dr. B...