Modern Healthspan

Here Dr Sorrentino discusses mitochondria and muscle aging and results from trials of Urolithin A and NR in countering some of the ill effects. Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Su...

Here Dr Sorrentino discusses proteostasis, how it goes wrong with age and how raising NAD levels can help. Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Swi...

Apologies for missing the last two release dates. Hopefully back on track now! Here Dr Sorrentino introduces trigonelline a methylated form of nicotinic acid which can boost NAD levels. He also talks about his work at Singapore and the translation of longevity science into the clinic. Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular d...

Here Dr Maroon, talks about some of the latest work that they are doing at Pittsburgh University on direct stimulation of the brain with magnetic pulses, light and ultra-sound. Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the te...

Here Dr Maroon, talks about the supplements that he takes to help him with his exercise protocol. Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After starting to comp...

Here Dr Maroon, talks about stress, including eustress and distress and his way of handling stress (exercise!) Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers since 1980. After sta...

Here Dr Maroon, talks his personal diet and his thoughts on protein intake, sarcopenia, the ketogenic diet and omega-3 fatty acids. Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealers...

Here Dr Maroon, talks about research that he is working on with a colleague in India, Dr Pravat Mandal looking at ROS as a cause of Alzheimer's and glutathione as a possible preventative measure. Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Cen...

Here Dr Maroon, discusses his path to becoming a triathlete, his exercise protocol and his experience with hyperbaric oxygen therapy. Dr Joseph Maroon is an American neurosurgeon, author, and triathlon athlete. He is the professor and vice chairman of the Department of Neurological Surgery at the University of Pittsburgh Medical Center and has been the team neuroscientist for the Pittsburg Stealer...

Here Dr Seranova talks about the supplements she takes, and a couple that she does not. Also sleeping and a hack for getting better deep sleep. The new brain supplement that Dr Seranova talks about is now available. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of B...

Here Dr Seranova talks about her diet and exercise and how she thinks about these. Some links are affiliate links so we will earn a commission when they are used to purchase products. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK. 🌐Links in this e...

Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK. 🌐Links in this episode NMN Bio website: https://nmnbio.co.uk/ NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency https://www.sciencedirect.com/science/article/pii/S22111247...

Here Dr Seranova answers some questions on the paper from the first interview (https://youtu.be/fsuhtgKUZRg). Particular topics we discuss, mitochondria fragmentation, de novo pathway in neurons, difference between NR & NMN. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the Un...

Here Dr Seranova talks through her latest paper on the impact of NAD precursors (NR & NMN) on autophagy in human neuron Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK. 🌐Links in this episode NMN Bio website: https://nmnbio.co.uk/ NAD depletion...

Here Dr Gibala talks how to think about exercise routines and nutrition as well as sharing his own protocol and the current work of his lab Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In addition to basic, mechanistic studies on the regul...

Here Dr Gibala talks about what is VO2max, why it is important, how to measure and improve it. Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In addition to basic, mechanistic studies on the regulation of skeletal muscle energy metabolism, h...

Here Dr Gibala introduces interval training and discusses the various styles, and the benefits. Dr Martin Gibala is a Professor at McMaster University where his research examines the effects of exercise at the molecular to whole body level in both healthy individuals and people with chronic diseases. In addition to basic, mechanistic studies on the regulation of skeletal muscle energy metabolism,...

Here Dr Patel talks about his topical glutathione treatment Glutaryl and the recent trial that was conducted at McGill University. Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for over three decades, Patel is an internationally recognized expert, consultant, and lecturer on the Master Antioxidant Glu...

Here Dr Patel talks about the changes that happen with glutathione as we age, why it is important and what we can do to restore the levels. Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for over three decades, Patel is an internationally recognized expert, consultant, and lecturer on the Master Antiox...

Here Dr Patel talks about glutathione's major two functions in the body, as an antioxidant and a detoxifier. He also discusses measuring our glutathione levels and what would be a good value to aim for. Dr. Nayan Patel is an alumnus of the University Of Southern California School Of Pharmacy, where he now serves as adjunct faculty. A pharmacist for over three decades, Patel is an international...

Here Dr Conlon talks about her personal protocol, that she has decided on as a data driven scientist. We also discuss the next steps for Nuchido as a longevity company. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and h...

Here Dr Conlon talks about the human trial that she sponsored to evaluate the benefits of Time+ on humans. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healthspan. Dr Conlon has a passion for sharing the latest scie...

Here Dr Conlon talks through all the components of Nuchido Time+ and how they fit into the strategy of restoring NAD by activating the cell's natural mechanisms. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and heal...

Here Dr Conlon explains the biochemistry behind Nuchido Time+ and how it activates the salvage pathway through NAMPT to replenish cellular NAD in sustainable way. Dr Nichola Conlon is a molecular biologist specialising in the study of cellular aging. After a career in drug development, she founded Nuchido Laboratories to deliver disruptive innovation in the field of aging, rejuvenation and healths...

Here Professor Gorbunova about the naked mole rat and bowhead whale and what adaptions they have to enable them to live longer. From this she discusses how these adaptions might be translated into interventions for humans. Dr Vera Gorbunova is a biologist. As the Doris Johns Cherry Professor at the University of Rochester, she identified high molecular weight hyaluronan as the key mediator of canc...