Modern Healthspan

Is your oral health secretly dictating your cardiovascular and metabolic aging? Dr. Purnima Kumar, Chair of Periodontics at the University of Michigan, joins us to explain why the mouth must be integrated back into systemic medicine and how oral dysbiosis accelerates chronic conditions like heart disease and diabetes. We have treated oral health in isolation for decades, but modern longevity scien...

Discover how pulsed electromagnetic field (PEMF) therapy can mimic the systemic benefits of exercise, reverse sarcopenia, and activate mitochondrial health with Dr. Alfredo Franco-Obregón from the National University of Singapore. Learn how "magnetic mitohormesis" stimulates the TRPC1 calcium channel axis to improve muscle strength, boost ATP production, and fight chronic inflammation wi...

Discover how advanced blood-based assays and multi-modality screening can identify silent cellular changes before they impact your longevity protocol. Traditional cancer screenings are constrained by structural limitations, capturing less than twenty percent of eventual diagnoses due to strict age thresholds, invasive procedures, and systemic healthcare delays. Dr. Tarek Mouhieddine from the Dana-...

Discover how to tap into your body's ultimate internal repair system and unlock the hidden regenerative power of your own stem cells. In this episode of Modern Healthspan, we explore the extraordinary capability of the human body to heal itself from within. Stem cell scientist Christian Drapeau breaks down how our bone marrow acts as a continuous engine for cellular renewal, deploying stem cel...

Harvard Professor Dr. JoAnn Manson reveals the final results of the VITAL trial: a landmark study on Vitamin D, telomeres, and disease prevention. Is Vitamin D the most underrated molecule in longevity science? Dr. JoAnn Manson, Professor of Medicine at Harvard Medical School and lead investigator of the massive VITAL trial, joins us to present groundbreaking new data. We move past the traditional...

Discover how the "Brain Energy Gap" drives cognitive decline and how ketones can rescue starving neurons. Dr. Stephen Cunnane explains the science of metabolic health, the BENEFIC trial, and how to fuel a hybrid brain for long-term longevity. Is Alzheimer’s actually a fuel shortage in the brain? In this interview, world-renowned researcher Dr. Stephen Cunnane breaks down the "Brain...

Muscle scientist Dr Brad Schoenfeld on how to stay strong after 60. Dr Brad Schoenfeld is a professor of exercise science at Lehman College, New York, and one of the world's most cited researchers on muscle hypertrophy. In this interview we cover the practical science of building and maintaining muscle as you age with a focus on what actually matters for healthspan and independence. We discuss...

Dr. Howard Sesso of Harvard explains the results of the COSMOS trial, identifying who actually benefits from a daily multivitamin and how it impacts biological aging. Is a daily multivitamin a life-extending "insurance policy" or just a waste of money? In this clip, Dr. Howard Sesso, Co-Principal Investigator of the landmark COSMOS trial, breaks down the clinical evidence from over 21,00...

Senescent cells — cells that have stopped dividing but refuse to die — accumulate with age and are increasingly recognised as a key driver of age-related disease. Most people in the longevity space are familiar with senolytics like dasatinib and quercetin, but a potentially more precise approach is emerging: harnessing the immune system itself to find and eliminate senescent cells. Dr. Amit Sharma...

Longevity researcher Nir Barzilai on what centenarians reveal about aging and the four drugs scientists believe may target it directly. Dr Nir Barzilai has spent decades studying people who live to 100 and beyond. What he's found challenges many assumptions about aging, disease, and what we can actually do about them. In this conversation we cover what centenarian research really shows, includ...

GLP-1 drugs likesemaglutide and ozempic have become household names but how much do we reallyunderstand about what they're doing inside the body? In this episode I sit downwith Dr. Mikhail Kolonin, Professor and Director of the Center for Metabolicand Degenerative Diseases at UTHealth Houston's McGovern Medical School, whoselab has spent years uncovering the deeper biology of these drugs....

Dr. Anurag Singh, Chief Scientific Officer at Timeline Nutrition joins Modern Healthspan for an in-depth conversation about urolithin A and the science of mitophagy, the cellular process that cleans out damaged mitochondria. We explore the clinical evidence from multiple human trials: the ATLAS trial showing 12% muscle strength gains and 10% VO2 max improvements in sedentary middle-aged adults, in...

Dr. Valter Longo explains how fasting-mimicking diets make cancer cells vulnerable to treatment while protecting healthy tissue, plus the clinical evidence, safety protocols, and why oncologists remain skeptical. Dr. Valter Longo, author of "Fasting Cancer," breaks down decades of research on using fasting-mimicking diets (FMD) alongside conventional cancer therapies. Cancer cannot be st...

Dr. Luigi Ferrucci reveals what 60 years of Baltimore Longitudinal Study data shows about aging, inflammation, mitochondria, and the biomarkers that predict your health trajectory. In this conversation, Dr. Luigi Ferrucci, Scientific Director of the National Institute on Aging and director of the Baltimore Longitudinal Study of Aging, shares insights from the longest-running scientific study of hu...

Dr. DanPardi explains why creatine supplementation may help preserve cognitivefunction during sleep deprivation, aging, and high mental demand, plus thespecific dosing strategies most people miss.   In thisconversation, Dr. Dan Pardi breaks down the emerging science of creatine forbrain health. While creatine is famous for athletic performance, new researchshows it may help maintain cognitive func...

Dr. Allen Taylor spent 40 years at Tufts discovering how diet affects vision. Learn why high glycemic foods accelerate macular degeneration and cataracts—and what you can do to protect your eyes. Dr. Allen Taylor directed the Laboratory for Nutrition and Vision Research at Tufts University for four decades, pioneering groundbreaking discoveries about how nutrition impacts age-related eye diseases....

Your ferritin test doesn't measure what you think. Dr. Douglas Kell explains iron dysregulation, dormant microbes, and his controversial theory about chronic disease Dr. Douglas Kell, systems biologist at the University of Liverpool, presents his research on iron dysregulation and its potential role in chronic inflammatory diseases. In this conversation, he explains why ferritin in blood is ac...

Dr. Eric Plaisance explains how exogenous ketones may provide fasting benefits without dietary restriction - the hormetic effects of mimicking starvation while fed. Plus: ketone salts vs esters, his personal protocol, and why performance claims don't hold up. Dr. Eric Plaisance, Associate Professor at University of Alabama Birmingham, has spent over a decade studying exogenous ketone esters. H...

Dr. Mary Newport shares groundbreaking research analyzing cholesterol profiles across 40 years of studies, challenging conventional wisdom about saturated fat and heart health. We discuss her findings on MCT oil for brain health, the 288 caregiver reports showing cognitive improvements, and practical protocols for using coconut oil and ketones. Dr. Mary Newport, physician and Alzheimer's resea...

DESCRIPTION Leading hairrestoration surgeon Dr. Alan Bauman reveals the science behind hair loss,graying, and the evidence-based treatments that actually work—from medicationsto regenerative therapies. Dr. Alan Baumanis a board-certified hair restoration physician who has treated over 30,000patients and performed 14,000+ hair transplants in his 28-year career. In thisconversation, we explore the b...

Dr. Henry Mahncke reveals how an NIH-funded study showed brain training reversed brain aging markers by 10 years, why speed-based training is uniquely effective, and the future of brain health interventions. Dr. Henry Mahncke, CEO of Posit Science and creator of BrainHQ, discusses the groundbreaking INHANCE study that used PET scans to show brain training can reverse brain aging by 10 years. In th...

Dr. John Cramer, 92-year-old nuclear physicist, discusses participating in the first mitochondrial transplant trial for aging and his longevity theory. Dr. John Cramer is a 92-year-old emeritus professor at the University of Washington who has spent decades researching nuclear physics and quantum mechanics. Now, he's turned his attention to longevity, and he's not just theorizing. Dr. Cram...

Mayo Clinic's Dr. Sundeep Khosler discusses findings from the first major randomized controlled trial of senolytics in humans, revealing why cellular aging varies dramatically between individuals and what this means for longevity interventions. Dr. Sundeep Khosler, a physician-researcher at the Mayo Clinic, leads some of the first human clinical trials testing senolytics for aging and age-rela...

Professor Charles Brenner challenges the NAD decline myth and reveals why nicotinamide riboside (NR) works for metabolic stress, not aging. Learn about the Northwestern trial showing NR improved walking speed in peripheral artery disease while metformin failed, eight clinical trials proving anti-inflammatory effects, and why popular biomarker tests are measuring the wrong thing. In this conversati...

Could a decline in "plasmalogens" be a missing link in Alzheimer's and aging? Dr. Peter Meikle reveals why this critical brain lipid drops as we age and the surprising foods that might help restore it. In this interview, we sit down with Dr. Peter Meikle, Head of the Metabolomics Laboratory at the Baker Heart and Diabetes Institute, to explore the critical role of plasmalogens in hum...