Modern Healthspan

Dr. Martin Picard, head of the Mitochondrial Psychobiology Laboratory at Columbia University, explains how cellular energy constraints and emotional stress drive biological aging. Discover how psychological allostatic load burns up to 60% more cellular energy, why hair graying is naturally reversible upon recovery, and how providing periods of physiological rest allows your mitochondria to restore...

Join Dr. John Sedivy, Director of the Center on the Biology of Aging at Brown University, as he explains how ancient jumping genes (LINE-1 retrotransposons) awaken as our epigenome decays, driving chronic sterile inflammation and cellular aging. Discover how reverse transcriptase inhibitors and epigenetic maintenance can slow biological aging clocks and protect tissue healthspan. What if ancient v...

Join us as Dr. Irina Conboy, former UC Berkeley professor and Chief Science Officer at Generation Lab, reveals a groundbreaking metabolic senolytic discovery. Learn how combining Dichloroacetate (DCA), Metformin, and a 10-fold lower dose of Navitoclax selectively eliminates senescent and cancer cells, extending post-treatment lifespan by 41.7% in old mice without inducing frailty or platelet toxic...

Join us as Dr. Connie Weaver, Distinguished Research Professor at San Diego State University and National Academy of Medicine member, reveals the hidden science of bone loss, calcium bioavailability, and the gut-bone axis. Discover why fractures kill more people than most realize, why modern plant-forward diets are inadvertently blocking mineral absorption, how soluble corn fiber halts postmenopau...

Join us as Dr. Noah Davidsohn, Co-Founder and Chief Scientific Officer of Rejuvenate Bio, reveals how systemic multi-gene therapy and in vivo partial cellular reprogramming can reverse age-related chronic diseases and double remaining lifespan. Discover the breakthrough science of AAV vector delivery, FGF21 and sTGFβR2 synergy, and companion animal clinical translation. What if a single gene thera...

In this episode, board-certified neurologist Dr. David Perlmutter, author of Brain Defenders, reveals how your brain’s immune cells, the microglia, hold the key to preventing cognitive decline and neurodegenerative disease. For decades, neurodegenerative research has fixated on amyloid plaques and tau tangles, treating the downstream smoke while ignoring the raging metabolic fire beneath. In this...

Can AI simulate your exact biology to predict how long you will live? Today we sit down with Dr. Dmitri Chebanov, computational biologist from Memorial Sloan Kettering Cancer Center and Chief Scientist at Holivita, to explore how AI digital twins and multi-omics are turning reactive medicine into proactive longevity. For decades, health optimization has relied on trial and error: try a new supplem...

Silicon Valley tech entrepreneur Haresh Patel joins Modern Healthspan to reveal how applying systems engineering and artificial intelligence can solve healthcare's chronic diagnostic crisis. After a 55-year struggle across 12 failed medical diagnoses, Haresh founded Sanare Health AI to synthesize fragmented medical records, map longitudinal health timelines, and uncover root causes of chronic...

USC Gerontology Professor Dr. Changhan David Lee breaks down the discovery of MOTS-c, a novel mitochondrial-derived peptide that functions as an exercise mimetic, cellular stress responder, and immunomodulator. Are mitochondria more than just cellular powerhouses? In this episode of Modern Healthspan, Dr David Lee, Associate Professor at the USC Leonard Davis School of Gerontology and co-discovere...

Discover how AI-guided Cardiac CT scanning detects hidden soft plaque and allows preventive cardiology to track and reverse heart disease before symptoms start Cardiovascular disease remains the leading cause of mortality worldwide, yet over half of affected individuals experience no warning signs before a major event. In this deep-dive interview, Dr. John Osborne, triple-board-certified preventiv...

Discover how original Yamanaka co-author Dr. Koji Tanabe uses automated iPSC cassettes and autologous stem cell secretomes to reverse cellular aging and repair damaged joints. In this landmark episode of Modern Healthspan, we sit down with Dr. Koji Tanabe, founder and CEO of iPS, Inc. and co-author of the historic 2007 Nobel Prize-winning paper on human-induced pluripotent stem cells (iPSCs). Dr....

Discover the truth about population-wide NAD+ optimization with Dr. Jin-Xiong She from Jinfinity Precision Medicine. We break down the clinical flaws behind the recent Janssen and Houtkooper human blood study claiming NAD levels do not decline with age or lifestyle habits. Learn how ethnicity, health status, NMN vs. NR synergies, and high-dose niacin vascular inflammation impact intracellular biom...

Discover why universally healthy diets don't exist and how metatranscriptomics (RNA sequencing) can track biological aging and reverse chronic disease risk before symptoms start. In this episode of Modern Healthspan, we sit down with Dr. Momo Vuyisich, co-founder of Viome and former lead genomics scientist at Los Alamos National Laboratory. Dr. Vuyisich shares why sequencing microbial DNA only...

Is your oral health secretly dictating your cardiovascular and metabolic aging? Dr. Purnima Kumar, Chair of Periodontics at the University of Michigan, joins us to explain why the mouth must be integrated back into systemic medicine and how oral dysbiosis accelerates chronic conditions like heart disease and diabetes. We have treated oral health in isolation for decades, but modern longevity scien...

Discover how pulsed electromagnetic field (PEMF) therapy can mimic the systemic benefits of exercise, reverse sarcopenia, and activate mitochondrial health with Dr. Alfredo Franco-Obregón from the National University of Singapore. Learn how "magnetic mitohormesis" stimulates the TRPC1 calcium channel axis to improve muscle strength, boost ATP production, and fight chronic inflammation wi...

Discover how advanced blood-based assays and multi-modality screening can identify silent cellular changes before they impact your longevity protocol. Traditional cancer screenings are constrained by structural limitations, capturing less than twenty percent of eventual diagnoses due to strict age thresholds, invasive procedures, and systemic healthcare delays. Dr. Tarek Mouhieddine from the Dana-...

Discover how to tap into your body's ultimate internal repair system and unlock the hidden regenerative power of your own stem cells. In this episode of Modern Healthspan, we explore the extraordinary capability of the human body to heal itself from within. Stem cell scientist Christian Drapeau breaks down how our bone marrow acts as a continuous engine for cellular renewal, deploying stem cel...

Harvard Professor Dr. JoAnn Manson reveals the final results of the VITAL trial: a landmark study on Vitamin D, telomeres, and disease prevention. Is Vitamin D the most underrated molecule in longevity science? Dr. JoAnn Manson, Professor of Medicine at Harvard Medical School and lead investigator of the massive VITAL trial, joins us to present groundbreaking new data. We move past the traditional...

Discover how the "Brain Energy Gap" drives cognitive decline and how ketones can rescue starving neurons. Dr. Stephen Cunnane explains the science of metabolic health, the BENEFIC trial, and how to fuel a hybrid brain for long-term longevity. Is Alzheimer’s actually a fuel shortage in the brain? In this interview, world-renowned researcher Dr. Stephen Cunnane breaks down the "Brain...

Muscle scientist Dr Brad Schoenfeld on how to stay strong after 60. Dr Brad Schoenfeld is a professor of exercise science at Lehman College, New York, and one of the world's most cited researchers on muscle hypertrophy. In this interview we cover the practical science of building and maintaining muscle as you age with a focus on what actually matters for healthspan and independence. We discuss...

Dr. Howard Sesso of Harvard explains the results of the COSMOS trial, identifying who actually benefits from a daily multivitamin and how it impacts biological aging. Is a daily multivitamin a life-extending "insurance policy" or just a waste of money? In this clip, Dr. Howard Sesso, Co-Principal Investigator of the landmark COSMOS trial, breaks down the clinical evidence from over 21,00...

Senescent cells — cells that have stopped dividing but refuse to die — accumulate with age and are increasingly recognised as a key driver of age-related disease. Most people in the longevity space are familiar with senolytics like dasatinib and quercetin, but a potentially more precise approach is emerging: harnessing the immune system itself to find and eliminate senescent cells. Dr. Amit Sharma...

Longevity researcher Nir Barzilai on what centenarians reveal about aging and the four drugs scientists believe may target it directly. Dr Nir Barzilai has spent decades studying people who live to 100 and beyond. What he's found challenges many assumptions about aging, disease, and what we can actually do about them. In this conversation we cover what centenarian research really shows, includ...

GLP-1 drugs likesemaglutide and ozempic have become household names but how much do we reallyunderstand about what they're doing inside the body? In this episode I sit downwith Dr. Mikhail Kolonin, Professor and Director of the Center for Metabolicand Degenerative Diseases at UTHealth Houston's McGovern Medical School, whoselab has spent years uncovering the deeper biology of these drugs....

Dr. Anurag Singh, Chief Scientific Officer at Timeline Nutrition joins Modern Healthspan for an in-depth conversation about urolithin A and the science of mitophagy, the cellular process that cleans out damaged mitochondria. We explore the clinical evidence from multiple human trials: the ATLAS trial showing 12% muscle strength gains and 10% VO2 max improvements in sedentary middle-aged adults, in...