Modern Healthspan

In this episode Dr Davidsohn discusses taking RJB01 to trial with humans for a rare heart disease and how gene therapy is viewed by the FDA. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rejuvenate Bio website https://www.rejuvenatebio.com/ Dr Davidsohn's paper mentioned in the interview A...

In this episode Dr Davidsohn discusses how the gene therapy helps with heart health and is only required one time. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rejuvenate Bio website https://www.rejuvenatebio.com/ Dr Davidsohn's paper mentioned in the interview A single combination gene th...

In this episode Dr Davidsohn talks about the first therapy Rejuvenate Bio is working on which restores a more youthful protein expression in the liver which then impacts the rest of the body. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rejuvenate Bio website https://www.rejuvenatebio.com/...

In this episode we discuss some of Dr Davidsohn's background, the mission of Rejuvenate Bio and the gene therapy that was developed at Dr Church's lab and is now being used to treat companion dogs. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rejuvenate Bio website https://www.rejuvenatebi...

In this episode Dr Verburgh talks about his personal longevity protocol. Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases And is available here: https://pubmed.ncbi.nlm.nih.gov/25470422/ Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, me...

In this episode Dr Verburgh talks about his theory of aging and why he thinks that epigenetic dysregulation is the most fundamental of the hall marks. Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases And is available here: https://pubmed.ncbi.nlm.nih.gov/25470422/ Dr Kris Verburgh is a medical doctor and research...

In this episode Dr Verburgh talks about his thoughts on the escape velocity of aging and what it might mean for humanity. Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases And is available here: https://pubmed.ncbi.nlm.nih.gov/25470422/ Dr Kris Verburgh is a medical doctor and researcher at the Free University of...

In this episode Dr Verburgh talks about developments in using mobile phones as a diagnostic device. Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a partner and head...

In this episode Dr Verburgh talks about some of the upcoming technologies which will impact the longevity space in the coming years, including improvements in gene editing and epigenetics. Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is...

In this episode Dr Verburgh talks about how to optimise our micronutrient intake. This is not simple as it is sometimes difficult to know whether you have sufficient of certain micronutrients just by looking at the blood. Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book...

In this episode Dr Verburgh talks what are the key elements of a longevity diet. Dr Verburgh first wrote a paper on this subject in 2015, which introduced the term Nutrigerontology. The paper is: Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases And is available here: https://pubmed.ncbi.nlm.nih.gov/25470422/ Dr K...

In this episode Dr Verburgh talks about his three (well, he cheats a bit and squeezes in 5!) supplements for aging. Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a p...

In this episode Dr Verburgh talks about the founding of NOVOS and why NMN was their choice for the NAD booster Dr Kris Verburgh is a medical doctor and researcher at the Free University of Brussels where his focus is the aging process, metabolism and nutrition. He published his first book when he was 16 and his latest is the Longevity Code. Dr Verburgh is a co-founder of NOVOS labs and is a partne...

In this episode Dr Naiman talks about the three forms of exercise, walking, resistance and cardio, trading intensity for duration and the importance of VO2max. Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exerc...

In this episode Dr Naiman talks about metabolic health and how it is the same thing as body composition and what we can do to have the best metabolic health. Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercis...

Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author of ‘The PE Diet’. In the book Dr Naiman explains the protein to energy ratio and how to use it to optimize food an...

In this episode Dr Naiman talks how protein is absorbed into the body, what would be a good eating pattern and the difference between plant and animal proteins. Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exer...

In this episode Dr Naiman talks about how mTOR is activated and why our metabolic health is of much greater importance than the amount of protein that we eat. Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exerci...

In this episode Dr Naiman provides a more practical view on the PE Diet. What P:E ratio we should aim for, what is an optimal protein intake and how to find the P:E ratio for various foods. Dr. Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical im...

In this episode Dr Naiman talks about his personal journey through various diets to his formulation of the PE Diet. Dr Ted Naiman is a board-certified Family Medicine physician in the department of Primary Care at a leading medical center in Seattle. His personal research and medical practice are focused on the practical implementation of diet and exercise for health optimization. He is the author...

In this episode Dr Cohen talks about the current interventions that he sees as having the most potential but also about the need for precision medicine as there are many causes for Alzheimer's, diabetes etc. and to treat the disease we need to understand the underlying cause. This also would involve changes in the way trials are run, to be able to identify the markers appropriate for each interven...

In this video Dr Cohen talks CohBar, a company that he co-founded with Professor Nir Barzilai and some of the work they are doing, as well as the latest developments in his lab. He also discusses the need for precision medicine in addressing diseases of aging. Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE https://www.nature.com/articles/s41380-022-...

In this video Dr Cohen talks about how mitochondria age and how they are not all the same but different in each tissue. Mitochondrial DNA variation in Alzheimer’s disease reveals a unique microprotein called SHMOOSE https://www.nature.com/articles/s41380-022-01769-3 Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitoch...

In this episode Dr Cohen talks about humanin, SHLEP2 and MTOS-c, how these impact our health, how this varies with ethnicity and age. Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mitochondria-derived peptides and their possible therapeutic benefits for diabetes, Alzheimer's and other diseases of aging, an area which...

In this episode Dr Cohen talks about SHMOOZE a new MDP that his lab has discovered and recently published a paper on. He also discusses SNPs, mutations in the MOTS-c and Humanin genome which impacts their peptides with knock on effects on diabetes and cognitive decline. Professor Pinchas Cohen is the dean of the USC Leonard Davis School of Gerontology. He is a pioneer in the emerging science of mi...