The Synthesis of Wellness®

In this episode, we dive into the complexities of Bartonella, a genus of gram-negative, facultative intracellular bacteria known for its ability to evade the immune system and persist in host cells such as endothelial cells and erythrocytes. We explore the specific pathogenesis mechanisms of Bartonella henselae, including its interaction with cell adhesion molecules which facilitate its intracellu...

In this episode, we explore the intricacies of neuronal communication, delving into how neurons transmit signals through synaptic connections using neurotransmitters like glutamate and GABA. We also examine the effects of neurotoxins, such as heavy metals and environmental pollutants, on these critical synaptic pathways, leading to cognitive and neurological impairments. Lastly, we discuss neuropr...

In this episode, we explore the role of probiotics in managing histamine levels and mast cell activation syndrome (MCAS), particularly in the context of rebuilding the gut microbiome. We discuss which probiotic strains could contribute to symptoms (in the short term) due to their histamine-producing properties, such as Lactobacillus casei and Lactobacillus reuteri, and we highlight beneficial stra...

Today we are diving into the world of natural turkey tail mushroom supplements. I am excited to introduce our special guest, the founder and owner of Tremetes, LLC. Our guest today brings nearly two decades of broad commercial experience with some of the world’s leading global life science companies. With extensive knowledge across multiple therapeutic areas such as diabetes, cardiovascular and me...

This episode dives into the emerging concept of psychobiotics, exploring how these live (probiotic) microorganisms can positively impact mental health by interacting with the gut-brain axis. We'll provide an in-depth look at the anatomy of the gut lining and the enteric nervous system, explaining how these pathways facilitate communication between the gut and the brain. Additionally, we'll...

In this episode, we explore the science behind microplastics (MPs) and nanoplastics (NPs), focusing on their effects on the liver and gut microbiome. We'll examine how these particles can disrupt cellular functions in hepatocytes, leading to oxidative stress and inflammation, and we will also discuss recent research findings related to MP exposure and gut dysbiosis. We will finish by addressin...

We are honored to have Cory Rasmussen and Dallin Hardy from Hardy Nutritionals on the podcast. Cory oversees the company's financial activities, including strategy, accounting, and reporting. Dallin, a research scientist, focuses on nutraceutical product development, consulting health professionals on micronutrients, and collaborating on research in integrative psychiatry. We'll explore ho...

In today's episode, we dive into the APOE4 gene variant and its significant role in neurodegeneration, particularly Alzheimer's disease. We'll start by exploring the basics of the APOE gene, its expression in the liver and brain, and how it impacts lipid metabolism. Finally, we'll discuss the specific challenges faced by APOE4 carriers and offer practical strategies, including life...

In this episode, we dive into the critical process of methylation and its significance in detoxification, mood regulation, and overall cellular function. We explain the step-by-step conversion of dietary folate to its active form and how gene mutations can impair this process, leading to reduced SAMe levels, high homocysteine, and various health issues. Finally, we discuss practical strategies to...

In this part 2 episode, we dive into the pathology and symptoms of Babesiosis, exploring how the Babesia parasite infects red blood cells and evades the immune system. We discuss various labs and biomarkers to look out for. We then address various treatment protocols featuring anti-malarials including herbal supplements such as artemisinin and cryptolepis, and proteolytic enzymes like lumbrokinase...

In this episode, we explore the intricacies of Babesia and Babesiosis, exploring how this protozoan parasite infects red blood cells and evades the immune system. We discuss the various pathological effects of the infection, including impaired blood flow, tissue ischemia, and multi-organ dysfunction syndrome. Additionally, we cover common symptoms, relevant bloodwork indicators, and an overview of...

We are honored to be joined by Brendan Gaughran. Brendan Gaughran, the founder of Liver Medic , holds a degree in Molecular Biology from the University of Connecticut and an MBA from Bentley University. He is an expert in gut health, liver health, the endocrine system, adrenal fatigue, and optimal diets. Brendan frequently conducts health lectures for both physicians and the general public. Throug...

In today's episode, we explore the connection between biotoxin illness (including Lyme disease) and dysautonomia, as well as nervous system dysfunction, in general. And, we outline strategies for supporting nervous system repair through addressing the root cause and using strategic phospholipid support. Topics: 1. Introduction to the Nervous System - Overview - Central Nervous System (CNS): Br...

In this episode, we delve into the science behind peptide bioregulators, specifically focusing on Glandokort, a natural extract from the adrenal gland. We explore the unique characteristics and mechanisms of peptide bioregulators, highlighting their tissue-specific effects and role in gene regulation. Additionally, we provide an overview of the adrenal glands' anatomy and functions, and discus...

In today's episode, we explore the role of Thymosin Alpha 1 Peptide in modulating the immune system, specifically its effects on Th1 and Th2 responses. The episode further delves into the mechanisms by which Borrelia burgdorferi evades immune detection and offers strategies to enhance immune effectiveness against this stealthy pathogen. Additionally, we discuss the broader implications of immu...

In this episode, we undertake a detailed examination of the diverse mechanisms of action underlying various binders employed in detoxification protocols, with a particular focus on their application in biotoxin illnesses such as Lyme disease. We dissect the differential efficacy of bile acid sequestrants like cholestyramine versus natural binders such as activated charcoal and zeolite, elucidating...

Today I am addressing the "early steps" in combatting Lyme or mold. So, I begin by diving into the phenomenon of Herxheimer reactions, elucidating its occurrence following antimicrobial therapy initiation for Lyme disease. Through this, I explore the intricate interplay between microbial factors, such as the release of endotoxins (LPS), and host immune responses, leading to a cascade of...

Today, we are delighted to introduce Justin Bosley, the President and Head Chemist at Evexia Science. Raised amidst health challenges that confounded traditional medical solutions, Justin embarked on a lifelong quest for remedies. Fueled by an innate curiosity and a passion for health and science, he pursued a degree in nutritional science at Brigham Young University. Subsequently, driven by an un...

We are diving into the intricate processes of liver detoxification, from the anatomy of the liver and its blood flow circuitry to the phases of detoxification involving enzymes and conjugation reactions. I highlight the importance of supporting optimal liver function to prevent toxin accumulation and associated symptoms, underscoring the significance of various compounds and peptides, such as Dihy...

We are talking all things superfoods today with a focus on enhancing sleep quality and supporting sustained energy levels. Andrew and Allan are the Co-Founders of NoonBrew which is the first superfood tea designed for the afternoon slump. They wanted an alternative to coffee that didn’t keep you up at night and saw that no other beverage company was truly addressing the afternoon energy market. In...

In this episode, we set the stage by going through the intricate anatomy of the gut lining, providing a comprehensive understanding of its layers and cellular components. We, then, explore how six gut-supporting peptides and compounds offer promising therapeutic avenues. From larazotide acetate's tight-junction regulation to KPV's anti-inflammatory properties and BPC-157's reparative e...

In this episode, we delve into intracellular NAD+ testing and explore self-experimentation aimed at optimizing NAD+ synthesis. From supporting the salvage pathway, de novo synthesis, and the Preiss-Handler pathway to inhibiting the CD38 enzyme, we will uncover some key nutrients and precursors that will enhance NAD+ stores and production. Topics: 1. Importance of NAD+ - Cellular processes involvin...

We explore how biotoxins impair cellular function and induce neuroinflammation, leading to systemic inflammation, chronic fatigue, and mitochondrial dysfunction. We also cover how biotoxins disrupt the HPA axis, affecting the body's stress response and adrenal function. Additionally, the conversation presents strategies to mitigate this energy deficiency and combat fatigue in the context of CI...

We are honored to have Emily Johnson on the show today. Emily Johnson, MS, RD, is a registered dietitian with a Master's degree in nutrition interventions, communication, and behavior change from Tufts University. Her background includes clinical nutrition research, health writing, advising, and consulting within the tech sector. At Veri , she is the Research Lead, serving as the health and nu...

In this episode, we explore the intricate structure and functions of mitochondria, focusing on the electron transport chain complexes and the generation of reactive oxygen species. We delve into the significance of lipid composition in maintaining mitochondrial integrity, the detrimental effects of ROS-induced lipid peroxidation, and how SS-31 can prevent this damage. Additionally, we discuss the...