The Incubator's Journal Club

Shifting outlooks after neonatal encephalopathy in the era of therapeutic hypothermia. Christoffel K, Mulkey SB.Pediatr Res. 2025 Jun 4. doi: 10.1038/s41390-025-04156-0. Online ahead of print. PMID: 40467976 Review. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @n...

Treatment of Hypotension of Prematurity: a randomised trial. Alderliesten T, Arasteh E, van Alphen A, Groenendaal F, Dudink J, Benders MJ, van Bel F, Lemmers P.Arch Dis Child Fetal Neonatal Ed. 2025 May 24:fetalneonatal-2024-328253. doi: 10.1136/archdischild-2024-328253. Online ahead of print. PMID: 40413017 Support the show As always, feel free to send us questions, comments, or suggestions to ou...

In this week’s Journal Club, Ben and Daphna dive into the latest report from the American Academy of Pediatrics on the management of patent ductus arteriosus (PDA) in preterm infants. They dissect the nuances of prophylactic versus selective treatment, review recent meta-analyses, and explore why early intervention might not yield better outcomes despite effective PDA closure. They also break down...

Trajectory of Postnatal Oxygen Requirement in Extremely Preterm Infants. Groves AM, Bennett MM, Loyd J, Clark RH, Tolia VN.J Pediatr. 2025 Feb;277:114414. doi: 10.1016/j.jpeds.2024.114414. Epub 2024 Nov 20.PMID: 39577761 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitte...

Diagnostic accuracy of an over-the-counter infant pulse oximeter for cardiorespiratory events. Travers CP, Nakhmani A, Armstead KM, Benz RL, Foshee KM, Carlo WA.Arch Dis Child Fetal Neonatal Ed. 2025 May 12:fetalneonatal-2025-328540. doi: 10.1136/archdischild-2025-328540. Online ahead of print. PMID: 40355254 Support the show As always, feel free to send us questions, comments, or suggestions to o...

A Hospital-Based Initiative for Infant Safe Sleep Practice. Decker CM, Dunlevey E, Nguyen L, Stence KJ, McCarty E, Jean-Charles TG, Trego T, Ma ZQ.Pediatrics. 2025 Feb 1;155(2):e2024067659. doi: 10.1542/peds.2024-067659.PMID: 39799962 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Insta...

The effect of maternal position on cerebral oxygenation in premature infants during Kangaroo care: a randomised controlled trial. Stapleton I, Murphy S, Vaughan S, Walsh BH, Natchimuthu K, Livingstone V, Dempsey E.J Perinatol. 2025 Apr 5. doi: 10.1038/s41372-025-02287-0. Online ahead of print. PMID: 40186001 Support the show As always, feel free to send us questions, comments, or suggestions to ou...

Neonatologists' perceptions of uncertainty: a national survey. Rholl E, Krick JA, Leuthner SR, Pan AY, Challa SA, Kukora S.J Perinatol. 2025 Apr 19. doi: 10.1038/s41372-025-02292-3. Online ahead of print. PMID: 40253559 No abstract available. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show...

Hydrostatic low-volume enemas in infants with birth weight ≤1000 g or gestational age ≤28 weeks: A controlled interventional study. Stock T, Kamp AM, Waitz M, Riedl-Seifert T, Jenke AC.J Pediatr Gastroenterol Nutr. 2025 May 8. doi: 10.1002/jpn3.70055. Online ahead of print. PMID: 40344423 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast...

The new normal: parental use of online health communities in the NICU. Adams SY, Tucker R, Lechner BE.Pediatr Res. 2022 Jun;91(7):1827-1833. doi: 10.1038/s41390-021-01684-3. Epub 2021 Aug 17.PMID: 34404928 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast...

In this week’s Journal Club, Ben and Daphna unpack a wide range of recent neonatal studies with pragmatic, practice-centered discussion. First, they explore a study on low-dose dexamethasone for BPD in preterm infants, showing potential benefits in brain development and motor outcomes—despite ongoing concerns about long-term effects. Next, they discuss a large dataset analysis of oxygen and respir...

Intermittent sigh breaths during high-frequency oscillatory ventilation in preterm infants: a randomised crossover study. Hough JL, Jardine L, Hough MJ, Steele M, Greisen G, Heiring C.Arch Dis Child Fetal Neonatal Ed. 2025 Apr 17;110(3):297-302. doi: 10.1136/archdischild-2024-327445.PMID: 39406472 Clinical Trial. Support the show As always, feel free to send us questions, comments, or suggestions...

Effect of kangaroo mother care in low birth weight infants on human milk intake: a randomized controlled trial. Sinha B, Mazumder S, Thakur A, Devi S, More D, Ashorn P, Sommerfelt H, Kurpad A, Bhandari N.Am J Clin Nutr. 2025 May;121(5):1109-1116. doi: 10.1016/j.ajcnut.2025.02.006. Epub 2025 Feb 11.PMID: 39947481 Free article. Clinical Trial. Support the show As always, feel free to send us questio...

Interprofessional perspectives on non-invasive respiratory support practices in extremely preterm infants: a Canadian survey. Martinez TA, Remmer E, Mardakis S, Leone M, Boyer J, Lv S, Beltempo M, Sant'Anna G, Shalish W.J Perinatol. 2025 Apr 12. doi: 10.1038/s41372-025-02291-4. Online ahead of print. PMID: 40221609 Support the show As always, feel free to send us questions, comments, or sugge...

Prenatal Cannabis Use and Neonatal Outcomes: A Systematic Review and Meta-Analysis. Lo JO, Ayers CK, Yeddala S, Shaw B, Robalino S, Ward R, Kansagara D.JAMA Pediatr. 2025 May 5:e250689. doi: 10.1001/jamapediatrics.2025.0689. Online ahead of print. PMID: 40323610 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also co...

Near-infrared spectroscopy during respiratory support at birth: a systematic review. Monnelly V, Nakwa F, Josephsen JB, Schmölzer GM, Solevåg AL, Rabi Y, Wyckoff MH, Weiner GM, Liley HG; International Liaison Committee on Resuscitation Neonatal Life Support Task Force. Arch Dis Child Fetal Neonatal Ed. 2025 Apr 29:fetalneonatal-2025-328577. doi: 10.1136/archdischild-2025-328577. Online ahead of pr...

Neurodevelopmental outcomes at age 3 years of preterm infants born at 22-31 weeks' gestation. Kono Y, Kusuda S, Nishida T, Mori R, Toyoshima K, Sasaki H, Yonemoto N, Uchiyama A, Fujimura M; INTACT Study Group. J Perinatol. 2025 Mar 26. doi: 10.1038/s41372-025-02268-3. Online ahead of print. PMID: 40140596 Support the show As always, feel free to send us questions, comments, or suggestions to...

In this special anniversary edition of the Journal Club, Ben and Daphna celebrate four years of The Incubator Podcast while diving into a compelling lineup of neonatal studies. The episode kicks off with a review of a phase 2 multicenter trial on the safety of furosemide in preterm infants at risk for BPD. Despite widespread Lasix use in NICUs, data on dosing and safety have been lacking—this stud...

Postnatal dexamethasone treatment for preterm infants at high risk for bronchopulmonary dysplasia is associated with improved regional brain volumes: a prospective cohort study. Chandwani R, Kline J, Altaye M, Parikh N.Arch Dis Child Fetal Neonatal Ed. 2025 May 13:fetalneonatal-2024-328438. doi: 10.1136/archdischild-2024-328438. Online ahead of print. PMID: 40360237 Support the show As always, fee...

In this week’s Journal Club, Ben and Daphna dissect six critical studies reshaping our understanding of neonatal care. Kicking off with the Canadian Neonatal Network’s multicenter cohort on inhaled nitric oxide (iNO), they explore how early pulmonary hypertension responsiveness to iNO may predict survival in preterm infants. They then examine a poignant study on maternal decision regret following...

Effects of liberal versus restrictive transfusion strategies on intermittent hypoxaemia in extremely low birthweight infants: secondary analyses of the ETTNO randomised controlled trial. Franz AR, Engel C, Bassler D, Rüdiger M, Thome UH, Maier RF, Krägeloh-Mann I, Essers J, Bührer C, Bittrich HJ, Roll C, Höhn T, Ehrhardt H, Boettger R, Körner HT, Stein A, Neuberger P, Henriksen TB, Greisen G, Poet...

Mother's Own Milk Provision During the First 12 Weeks of Life by Gestational Age. Patel AL, Wilson J, Holmes M, Johnson TJ.JAMA Netw Open. 2025 Mar 3;8(3):e250024. doi: 10.1001/jamanetworkopen.2025.0024.PMID: 40042846 Free PMC article. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through...

Lung Recruitment Before Surfactant Administration in Extremely Preterm Neonates: 2-Year Follow-Up of a Randomized Clinical Trial. Gallini F, De Rose DU, Iuliano R, Romeo DM, Tana M, Paladini A, Fusco FP, Nobile S, Cota F, Tirone C, Aurilia C, Lio A, Esposito A, Costa S, D'Andrea V, Ventura ML, Carnielli V, Dani C, Mosca F, Fumagalli M, Scarpelli G, Giordano L, Fasolato V, Petrillo F, Betta P,...

Cord Blood Treatment for Children With Cerebral Palsy: Individual Participant Data Meta-Analysis. Finch-Edmondson M, Paton MCB, Webb A, Reza Ashrafi M, Blatch-Williams RK, Cox CS Jr, Crompton K, Griffin AR, Kim M, Kosmach S, Kurtzberg J, Nouri M, Ri Suh M, Sun J, Zarrabi M, Novak I.Pediatrics. 2025 Apr 11:e2024068999. doi: 10.1542/peds.2024-068999. Online ahead of print. PMID: 40210215 Support the...

Funisitis increases the risk of death or cerebral palsy in extremely preterm infants. Jain VG, Parikh NA, Rysavy MA, Shukla VV, Saha S, Hintz S, Jobe A, Carlo WA, Ambalavanan N; Eunice Kennedy Shriver NICHD Neonatal Research Network. Am J Obstet Gynecol. 2025  Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also cont...