The Incubator's Journal Club

Azithromycin therapy for prevention of chronic lung disease of prematurity (AZTEC): a multicentre, double-blind, randomised, placebo-controlled trial. Lowe J, Gillespie D, Aboklaish A, Lau TMM, Consoli C, Babu M, Goddard M, Hood K, Klein N, Thomas-Jones E, Turner M, Hubbard M, Marchesi J, Berrington J, Kotecha S.Lancet Respir Med. 2024 Aug;12(8):608-618. doi: 10.1016/S2213-2600(24)00079-1. Epub 20...

Advancing neonatal autopsy by strengthening physician belief and fostering effective family communication. Kratimenos P, Simonti G, Kinney HC.Pediatr Res. 2025 Mar 31. doi: 10.1038/s41390-025-04031-y. Online ahead of print. PMID: 40164873 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through I...

In this Journal Club episode, Ben and Daphna review several impactful studies shaping neonatal care. They begin with a secondary analysis of the ETTNO trial, which examined whether liberal transfusion thresholds reduce intermittent hypoxemia or improve neurodevelopmental outcomes in extremely low birth weight infants. Despite prior concerns, the study found no benefit to liberal thresholds, suppor...

Furosemide Safety in Preterm Infants at Risk for Bronchopulmonary Dysplasia: A Randomized Clinical Trial. Greenberg RG, Lang J, Smith PB, Shekhawat P, Courtney SE, Hudak ML, Moya F, Iyengar A, Eldemerdash A, Bloom B, Go M, Hanna M, Rhein L, Aliaga S, Lewis T, Febre A, Kiefer AS, Bhatt-Mehta V, Khoury JA, Selewski D, Anand R, Martz K, Payne EH, Zimmerman KO, Benjamin DK Jr, Laughon M; Best Pharmace...

Seven-day versus 14-day antibiotic course for culture-proven neonatal sepsis: a multicentre randomised non-inferiority trial in a low and middle-income country. Dutta S, Nangia S, Jajoo M, Sundaram M, Kumar M, Shivanna N, Gathwala G, Nesargi S, Jain S, Kumar P, Saili A, Karthik A, Tripathi S, Bandiya P, Dalal P, Ray P, Randhawa VS, Saigal K, Radhakrishnan D, Venkatesh V, Jagannatha B, Sharma M, Na...

In this episode of The Incubator’s Journal Club, hosts Ben and Daphna open with exciting announcements, including details on the upcoming Delphi Neonatal Innovation Conference and new video content for their “Beyond the Beeps” series on YouTube. They also share updates on the Board Review Podcast, geared toward both board preparation and ongoing learning in neonatology. The team’s first paper disc...

Response to Inhaled Nitric Oxide and Mortality Among Very Preterm Neonates With Pulmonary Hypertension. Baczynski M, Weisz D, Thomas L, Fevrier S, Castaldo M, Soraisham A, Hyderi A, Agarushi R, Bhattacharya S, Lalitha R, Sidhu A, Abdul Wahab MG, Altit G, Hébert A, Louis D, Elsayed Y, Mitra S, Deshpande P, Kharrat A, Zhu F, Ting J, Yoon E, Shah PS, Jain A; Canadian Neonatal Network Investigators. J...

Evaluating decision regret after extremely preterm birth. Belden L, Kaempf J, Mackley A, Kernan-Schloss F, Chen C, Sturtz W, Tomlinson MW, Guillen U.Arch Dis Child Fetal Neonatal Ed. 2025 Feb 21;110(2):191-199. doi: 10.1136/archdischild-2024-327287.PMID: 39164062 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also c...

Short Duration of Antenatal Corticosteroid Exposure and Outcomes in Extremely Preterm Infants. Chawla S, Wyckoff MH, Lakshminrusimha S, Rysavy MA, Patel RM, Chowdhury D, Das A, Greenberg RG, Natarajan G, Shankaran S, Bell EF, Ambalavanan N, Younge NE, Laptook AR, Pavlek LR, Backes CH, Van Meurs KP, Werner EF, Carlo WA; National Institute of Child Health and Human Development (NICHD) Neonatal Resea...

Neonatal intermittent hypoxemia events are associated with later systemic hypertension. Martinez S, Chen Z, Di Fiore JM, Nguyen C, Minich NM, Hibbs AM.Pediatr Res. 2025 Jan 31. doi: 10.1038/s41390-025-03881-w. Online ahead of print. PMID: 39885241 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show...

Whole-Body Hypothermia for Neonatal Encephalopathy in Preterm Infants 33 to 35 Weeks' Gestation: A Randomized Clinical Trial. Faix RG, Laptook AR, Shankaran S, Eggleston B, Chowdhury D, Heyne RJ, Das A, Pedroza C, Tyson JE, Wusthoff C, Bonifacio SL, Sánchez PJ, Yoder BA, Laughon MM, Vasil DM, Van Meurs KP, Crawford MM, Higgins RD, Poindexter BB, Colaizy TT, Hamrick SEG, Chalak LF, Ohls RK, Ha...

In this episode of Journal Club, Ben and Daphna are back in the studio for a lively discussion on the latest neonatal research. They start by highlighting upcoming conferences, including the BPD Collaborative meeting, before diving into a mix of clinical and policy-driven studies shaping neonatal care. They explore a JAMA Pediatrics study on the risk of apnea following two-month vaccinations in pr...

Higher versus lower nasal continuous positive airway pressure for extubation of extremely preterm infants in Australia (ÉCLAT): a multicentre, randomised, superiority trial. Kidman AM, Manley BJ, Boland RA, Malhotra A, Donath SM, Beker F, Davis PG, Bhatia R.Lancet Child Adolesc Health. 2023 Dec;7(12):844-851. doi: 10.1016/S2352-4642(23)00235-3. Epub 2023 Oct 27.PMID: 38240784 Clinical Trial. Suppo...

Intraventricular Hemorrhage and Survival, Multimorbidity, and Neurodevelopment. Rees P, Gale C, Battersby C, Williams C, Carter B, Sutcliffe A.JAMA Netw Open. 2025 Jan 2;8(1):e2452883. doi: 10.1001/jamanetworkopen.2024.52883.PMID: 39761048  Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through...

Improvement Initiative: End-Tidal Carbon Monoxide Measurement in Newborns Receiving Phototherapy. Bahr TM, Shakib JH, Stipelman CH, Kawamoto K, Lauer S, Christensen RD.J Pediatr. 2021 Nov;238:168-173.e2. doi: 10.1016/j.jpeds.2021.07.008. Epub 2021 Jul 11.PMID: 34260896 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can...

Early hydrocortisone verses placebo in neonatal shock- a double blind Randomized controlled trial. Dudeja S, Saini SS, Sundaram V, Dutta S, Sachdeva N, Kumar P.J Perinatol. 2025 Feb 13. doi: 10.1038/s41372-025-02222-3. Online ahead of print. PMID: 39948354 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact...

Parental and Medical Classification of Neurodevelopment in Children Born Preterm. Richter LL, Janvier A, Pearce R, Bourque CJ, Church PT, Luu TM, Synnes A.Pediatrics. 2025 Feb 1;155(2):e2024066148. doi: 10.1542/peds.2024-066148.PMID: 39786567 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show throu...

In this week’s Journal Club, Ben and Daphna discuss six impactful studies shaping neonatal care. The conversation opens with a retrospective study exploring the timeline and factors influencing liberation from respiratory support in infants with severe bronchopulmonary dysplasia (BPD), offering valuable insights for parental counseling and care planning. A survey on enteral nutrition practices in...

Apnea After 2-Month Vaccinations in Hospitalized Preterm Infants: A Randomized Clinical Trial.   Greenberg RG, Rountree W, Staat MA, Schlaudecker EP, Poindexter B, Trembath A, Laughon M, Poniewierski MS, Spreng RL, Broder KR, Wodi AP, Museru O, Anyalechi EG, Marquez PL, Randolph EA, Aleem S, Kilpatrick R, Walter EB.JAMA Pediatr. 2025 Jan 6. doi: 10.1001/jamapediatrics.2024.5311. Online ahead of pr...

Effects of pregnancy-induced hypertension on early-onset neonatal thrombocytopenia.   Ye M, Zhou C, Li L, Wang L, Zhang M.BMC Pregnancy Childbirth. 2025 Jan 24;25(1):67. doi: 10.1186/s12884-025-07193-z. PMID: 39856602 Free PMC article. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Inst...

Outcomes of extremely preterm infants who participated in a randomised trial of dopamine for treatment of hypotension (the HIP trial) at 2 years corrected age.   Marlow N, Barrington KJ, ODonnell CPF, Miletin J, Naulaers G, Cheung PY, Corcoran JD, Khuffash E, Boylan GB, Livingstone V, Pons G, Straňák Z, Van Laere D, Macko J, Wiedermannova H, Dempsey EM; HIP consortium. Arch Dis Child Fetal Neonata...

EBNEO Commentary: Parent-Guided Developmental Intervention for Infants With Very Low Birth Weight.   Jayakumar S, Burris H, Duncan A, DeMauro SB.Acta Paediatr. 2025 Jan 30. doi: 10.1111/apa.17608. Online ahead of print. PMID: 39887768 No abstract available. Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact...

The Impact of Hospital Delivery Volumes of Newborns Born Very Preterm on Mortality and Morbidity.   Phibbs CS, Passarella M, Schmitt SK, Martin A, Lorch SA.J Pediatr. 2025 Jan;276:114323. doi: 10.1016/j.jpeds.2024.114323. Epub 2024 Sep 18.PMID: 39304118 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the...

Unbound bilirubin and risk of severe neurodevelopmental impairment in extremely low birthweight newborns.   Arnold CC, Maric I, Wong RJ, Tyson JE, Stevenson DK.Pediatr Res. 2025 Jan 23. doi: 10.1038/s41390-025-03872-x. Online ahead of print. PMID: 39849115 Support the show As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact...

Liberation from Respiratory Support in Bronchopulmonary Dysplasia. Kielt MJ, Zaniletti I, Lagatta JM, Padula MA, Grover TR, Porta NFM, Wymore EM, Jensen EA, Leeman KT, Levin JC, Evans JR, Yallapragada S, Nelin LD, Vyas-Read S, Murthy K; Children’s Hospitals Neonatal Consortium Severe BPD Focus Group. J Pediatr. 2024 Nov 7:114390. doi: 10.1016/j.jpeds.2024.114390. Online ahead of print. PMID: 39521...