MIB Agents OsteoBites and osTEAo

Kristen VanHeyst, DO from UH Rainbows Babies and Children's Hospital discusses and shares updates regarding a Phase I/II multi-centered, multi-continental trial, to assess the safety and efficacy of Vactosertib in adolescents and adults with recurrent, refractory or progressive osteosarcoma. Dr. Kristen VanHeyst is a pediatric hematologist/oncologist and a translational therapeutics-oriented p...

Camille and Mia are joined by OsteoWarriors Elise, Penelope, Sammy and Sloane to share their experiences and tips for traveling after limb salvage surgery, amputation, and/or during treatment. They discuss navigating the airport, what the deal is with wheelchairs at the aiport, getting through TSA with a prosthesis, how to find leg room in cramped airplanes and cars, managing public transportation...

Kevin Campbell, MD, a pediatric oncologist at Children's Mercy Kansas City and Clinical Assistant Professor of Pediatrics, University of Missouri-Kansas City School of Medicine discusses results from the Phase 1 study assessing the safety and toxicity of cabozantinib in combination with topotecan and cyclophosphamide for relapsed osteosarcoma and Ewing sarcoma. Dr. Kevin Campbell is a pediatri...

Rachel Offenbacher, MD, is an attending physician at Children’s Hospital at Montefiore (CHAM) and Assistant Professor, Pediatric Hematology, Oncology, Marrow and Blood Cell Transplantation at Montefiore Einstein. She joins us on OsteoBites to share her work on targeting urea cycle dysfunction to prevent and treat osteosarcoma metastasis. Since joining the Montefiore team, Dr. Offenbacher’s clinica...

Camille and Mia are joined by OsteoWarriors Jasmine, Penelope and Walker to share their experiences with local control strategies to remove osteosarcoma lung metastasis, including surgery, radiation therapy, and cryoablation. They cover everything from their reaction to hearing they needed a lung surgery, how they prepared for surgery - both mentally and pro tips for how to make yourself comfortab...

Donghan “Mo” Yang, PhD, is a researcher in the field of data science and health informatics.  He joins us on OsteoBites to introduce the development of the Osteosarcoma Explorer (OSE), a data commons with clinical, genomic, protein, and tissue imaging data for osteosarcoma research. The OSE is one of the flagship projects cultivated within the CPRIT-funded Pediatric Cancer Data Core (Director: Yan...

Jennifer Mack, MD, MPH from Dana-Farber Cancer Institute/Boston Children’s and Harvard Medical School join us on OsteoBites to discuss best practices for engaging patients in research and clinical trials. Dr. Mack is also part of the PE-CGS Network (Participant Engagement and Cancer Genome Sequencing) Count Me In Research Center team and she will be discussing reasons that patients may or may not...

Fan Yang, PhD is an Associate Professor at Stanford University with joint appointments in the Departments of Orthopaedic Surgery and Bioengineering joins OsteoBites to discuss her work on tissue engineering strategies for elucidating OS biology and drug discovery. Fan Yang, PhD is the founder and Director of Stanford Stem Cells and Biomaterials Engineering Laboratory, and also Co-director of Stanf...

Dr. David Shulman is a pediatric oncologist at Dana-Farber Cancer Institute. He studies novel therapies and biomarkers for patients with advanced sarcomas. In addition to early phase clinical trials, Dr. Shulman co-leads an effort to evaluate circulating tumor DNA, a type of "liquid biopsy," as a potential tool to improve the ways in which we treat patients with bone and soft tissue sarc...

A cancer diagnosis and the treatment that follows can trigger stress and anxiety. Camille is joined this week by Dr. Abby Rosenberg, an expert in helping AYA cancer patients manage stress. They chat about why being diagnosed as an adolescent/young adult has particular challenges, tools and techniques for managing stress, and how palliative care is different from hospice care (spoiler alert - it&#3...

David Freyer, DO, MS provides a review of hearing loss as a serious and permanent side effect caused by cisplatin chemotherapy, recent research regarding its prevention, and its relevance for young people treated for osteosarcoma. David R. Freyer, DO, MS is Professor of Clinical Pediatrics, Medicine, and Population and Public Health Sciences at the Keck School of Medicine, University of Southern C...

Dr. Andy Livingston is a clinician and researcher in Sarcoma Medical Oncology and holds a joint appointment in Pediatric Oncology, and is Co-director of the MD Anderson Adolescent and Young Adult (AYA) oncology program. His clinical and translational research is focused on developing new treatment strategies for patients with osteosarcoma and other bone sarcomas. Dr. Livingston joins us on OsteoBi...

Camille and Mia kick off Season 3 of osTEAo with a chat on friendships after a cancer diagnosis. With special guest Vicky, MIB Agents 2023 Junior Advisory Board president, Camille and Mia discuss how to rebuild a life with meaningful connections and friendships when treatment removes you from school, your sports and extracurricular activities, and seeing your friends everyday. In this frank and so...

Osteosarcoma Webinar Series: Keri Schadler, PhD and Kiri Ness, PT, PhD, FAPTA will partner to provide information about the importance of exercise for patients undergoing treatment as well as long term survivors of osteosarcoma. Together, they will provide a clinical perspective as well as an overview of the latest evidence that documents the need for and the initial success of exercise interventi...

Debra L. Friedman, M.D., is a professor of Pediatrics in the Division of Hematology and Oncology at the Monroe Carell Jr. Children's Hospital at Vanderbilt. She is the E. Bronson Ingram Chair of Pediatric Oncology and the leader of the Cancer Control and Prevention Program and directs the Cancer Survivorship programs at the Vanderbilt-Ingram Cancer Center. Dr. Friedman's research interests...

Joshua Nash is a PhD candidate under Dr. Adam Shlien at The Hospital for Sick Children in Toronto, Canada. Joshua's research focuses on leveraging transcriptomics and machine learning to understand the overarching biology of sarcomas and mesenchymal tumours and to develop more molecularly informed and prognosticating diagnostic subtypes. -- What We Do at MIB Agents: PROGRAMS: End-of-Life MISSI...

Ming Li, PhD, is Member of the Immunology Program at Memorial Sloan Kettering Cancer Center and Professor at Weill Cornell Graduate School of Medical Sciences. His laboratory studies immune regulation and its relevance to diseases including cancer. Recent work has focused on the signaling, metabolic, and transcriptional mechanisms of T cell regulation as well as tumor-elicited innate and adaptive...

In this episode, OsteoWarriors Camille and Mia interview three long term osteosarcoma survivors.  Hear from Maeve, Sloane, and Eva about their osteosarcoma stories, what the most difficult hurdles have been for them, and what advice they would give themselves if they could go back in time.  While osteosarcoma is a tough journey for most patients, this episode will fill you with hope. --- What We D...

Nilay Shah, MD is a clinician-scientist and Associate Professor in the Division of Hematology/Oncology/BMT at Nationwide Children’s Hospital. His primary clinical focus is on pediatric solid tumors, including neuroblastomas, tumors of the kidneys, and rare solid tumors of childhood. His research focuses on the molecular drivers of pediatric cancers and how new treatment approaches can be taken to...

In this episode, OsteoWarriors Camille and Mia share songs that have resonated with them during their life with cancer. Find out why Fight Song is not their preferred anthem for AYA cancer patients and why hope can feel like a four letter word. Listen in as they break down lyrics, discuss why osteosarcoma is like a masochistic toxic ex, and examine how music can heal and help validate the feelings...

OsteoBites Preguntas & Respuestas con Nino Rainusso, MD: Únase a nosotros para un episodio especial de OsteoBites en español. Nino Rainusso, MD del Texas Children's Hospital con preguntas de respuesta sobre el osteosarcoma de pacientes y cuidadores. El Dr. Nino Rainusso es miembro del equipo de tumores sólidos pediátricos y codirector del programa de cardiooncología del Texas Children'...

TCF-001 TRACK is a patient advocacy initiated, decentralized clinical trial enrolling patients with rare cancers and cancer of unknown primary. Patients can enroll remotely without a requirement to travel, and enrolled patients receive biomarker testing of tissue and blood at no cost, as well as treatment recommendations from a virtual molecular tumor board. This presentation will provide details...

Matteo Trucco, MD and Kurt Weiss, MD joins us on OsteoBites to describe the collaboration that led to the current Phase 1 clinical trial repurposing the alcoholism drug disulfiram to see if it can overcome the chemotherapy resistance seen in relapsed sarcomas, including osteosarcoma. Matteo Trucco is a Pediatric Oncologist and the Clinical Director of Pediatric Hematology/Oncology at Cleveland Cli...

Listen in this month as Mia and Sloane have a gab sesh about the daily interactions and challenges as an AYA living with cancer that get under their skin. Hear their thoughts on why there is a lot of room for improvement on Hollywood's representation of pediatric cancer patients, how cancer limits participation in a society that doesn't address the needs of people with disabilities, the di...

Dr. Fiona Freeman is an Assistant Professor in the School of Mechanical and Materials Engineering at University College Dublin (UCD). She graduated in Biomedical Engineering in 2011 and earned her PhD from the University of Galway in 2016, focusing on developing new strategies for bone tissue regeneration. Afterward, Dr. Freeman was awarded two prestigious postdoctoral fellowships: the Government...