MIB Agents OsteoBites and osTEAo

Osteosarcoma Webinar Series: Alexander Davies, DVM, PhD joins us on OsteoBites to discuss his work which is focused on dynamic tumor-microenvironment signaling cross-talk, signal integration, and the development of 3D organotypic and tissue models to study these interactions using live-cell microscopy techniques. Results from studies in the Davies Lab demonstrate the utility of a novel dynamic liv...

Join hosts Mia and Sammy on the latest episode of osTEAo, where they dive deep into the challenges of navigating life with cancer fatigue. In "Cancer Fatigue: How to Escape the Cancerverse," they are joined by OsteoWarriors Sloane and Matthew to explore the emotional and physical toll of living in the "Cancerverse" and to share personal stories of how they find moments of norma...

Dr. Damon Reed joins us on OsteoBites to discuss the vision for research on bone tumors from the Children's Oncology Group (COG) Bone Tumor Committee. Damon Reed, MD is the inaugural Head of the Division of Pediatric Solid Tumors and Chief of the Pediatric Sarcoma Service at Memorial Sloan Kettering Cancer Center. Dr. Reed founded the Sunshine Project, the Pediatric Cancer Foundation’s pediatric p...

Osteosarcoma Webinar Series: Chelsey Burke, MD, a physician-scientist from Memorial Sloan Kettering Cancer Center and an OutSmarting Osteosarcoma Young Investigator 2024 grant recipient, shares findings from her work studying the evolution of osteosarcoma tumors. At present, we have a limited understanding of how osteosarcoma tumors change with conventional treatment and go on to develop drug resi...

One of our MIB Agents OutSmarting Osteosarcoma 2024 grant recipients, Dr. Chris Richards, an Associate Professor from the University of Kentucky provides an overview of his funded work on macrophage engineered vesicles to treat pediatric osteosarcoma. This presentation focuses on the development of nanoscale vesicles derived from immune cells that can be utilized as immunomodulatory and therapeuti...

An osteosarcoma diagnosis translates to lots of time in the hospital and an unpredictable schedule that is driven by treatment plans and unexpected complications. Spending holidays and important days in the hospital can be particularly rough. OsteoWarriors Sammy, MacKenzie, and Matthew share their hospital holiday experiences, bad and good, from nausea ruining a pumpkin pie to breaking out of the...

One of our MIB Agents OutSmarting Osteosarcoma Young Investigator 2024 grant recipients, Arianexys Aquino-López, MD, PhD, a physician-scientist from Texas Children's Hospital/Baylor College of Medicine will provide an overview of her funded work on Repurposing Virus Specific T cells as Immune Therapy for Osteosarcoma. In this presentation, she discusses repurposing virus-specific T cells so that t...

Osteosarcoma Webinar Series: Osteosarcoma Webinar Series: One of our MIB Agents OutSmarting Osteosarcoma 2024 grant recipients, Dr. Shahana Mahajan, a Professor and Principal Investigator from Hunter College of the City University of New York will provide an overview of her funded work on repurposing drugs for metastatic osteosarcoma. Dr. Mahajan will share the recent findings from her lab on test...

Joanne Tuohy, DVM, PhD from Virginia Tech and the Virgina-Maryland College of Veterinary Medicine will be sharing information about canine trials studying histotripsy as a novel tumor ablation modality for treating osteosarcoma. Histotripsy is a focused ultrasound tumor ablation technique that is non-invasive, non-ionizing and non-thermal, and it also has potential to induce immunomodulatory effec...

Get in the Halloween spirit with OsteoWarriors Mia, Sammy, Gillian, MacKenzie, and Matthew who share spooky stories from their osteosarcoma treatment experiences. Find out why being diagnosed with osteosarcoma is like entering the Twilight Zone where things may seem normal, but weird and random things lurk. Hallucinations, disorientation, and delirium can be common side effects from pain and suppo...

Dr. Troy McEachron joined us on OsteoBites to discuss the molecular and cellular deconstruction of metastatic osteosarcoma. Immunotherapy holds great promise for a subset of patients whose tumors respond to this innovative and remarkable approach. The therapeutic benefit for patients with osteosarcoma has been largely underwhelming, prompting clinical, translational, and basic scientists to ask wh...

September marks Childhood Cancer Awareness Month and Back-to-School season. Mackenzie, Sloane, and Penelope join osTEAo host Sammy to discuss the challenges and feelings that can accompany going back to school. They share their personal stories about how their diagnoses interrupted their school and extracurricular activities, accessibility issues on campus, and resulting FOMO. Based on their own e...

For decades, academic clinical trials consortia have collaborated to optimize outcomes for childhood cancers through evaluating incremental improvements in conventional multi modality treatment regimes. There are now increasing opportunities to partner with industry to test new medicines in academic-sponsored trials, but these collaborative studies rarely contribute to marketing authorizations. Un...

Brigitte Brisson, DMV, DVSc, DACVS from the Ontario Veterinary College at the University of Guelph joined us on OsteoBites to introduce Magnetic Resonance guided High Intensity Focused Ultrasound as a treatment modality for osteosarcoma and describe preliminary results in canine patients. High Intensity focused ultrasound (HIFU) is a non-invasive percutaneous thermal ablation technique that allows...

This month osTEAo co-hosts Mia and Sammy are joined by OsteoWarrior Kara to tackle the ambivalent mix of emotions from good scan results. Good scans equal good vibes, right? Not necessarily. Mia, Sammy, and Kara get real about their reluctance to celebrate, the complications of sharing good news with their friends and family, and the guilt that can accompany good scan results. Like other long-term...

Diana Azzam, PhD joined us on OsteoBites to discuss her lab's work on functional precision medicine for the treatment of pediatric and adult cancers. This presentation describes the foundational principles of functional precision medicine as applied to pediatric cancers and how major technological improvements as well as an explosive broadening of the cancer pharmacopeia has enabled the bridgi...

Sabina Kaczanowska’s research focus is to understand the role of the immune system in shaping the microenvironment of metastasis during cancer progression. Specifically, she is investigating how myeloid cells orchestrate the immunosuppressive program in the pre-metastatic niche and how we can apply this knowledge of myeloid biology to design new immunotherapeutic strategies for the treatment of so...

Dr. Bhuvana Setty will join us on OsteoBites to discuss the role of adapting the immune system in the fight against cancer. She will discuss the ongoing study utilizing natural killer (NK) cells in combination with a chemotherapy backbone for patients with relapsed osteosarcoma and other sarcomas. She will discuss preclinical data supporting the utilization of NK cells in this patient population a...

In this episode of osTEAo, Mia is joined by Dr. Christopher Kuo, Matt, and Valerie to discuss the often forgotten and overlooked children in an AYA cancer diagnosis - the siblings. Dr. Kuo is a physician-scientist, and pediatric oncologist at Children's Hospital Los Angeles/USC Keck School of Medicine and he has lost two brothers, one to osteosarcoma (Stanley), during his AYA years. He recentl...

Dr. Olivier Elemento joins us on OsteoBites to dive into his Lab Team’s expansive precision medicine research, which combines Big Data analytics with experimentation to develop entirely new ways to help prevent, diagnose, understand, treat and ultimately cure disease. Dr. Elemento’s talk will uncover the principles and applications of genomic medicine, focus on the importance of tissue architectur...

José Granados Soler, DVM, MSc, PhD and Rachel Allavena, PhD from the University of Queensland School of Veterinary Science join us on OsteoBites to discuss exploring novel immunotherapies for canine osteosarcoma. During this presentation, they delve into a pioneering clinical trial for canine osteosarcoma, share cutting-edge insights and explore how novel immunotherapies could revolutionize treatm...

Matteo Trucco, MD joins us on OsteoBites to provide a preview of the FACTOR 2024 scientific panels in layperson terms with a brief overview of vocabulary and terms as a helpful resource for patients and families attending our FACTOR 2024 conference. Dr. Matteo Trucco is a pediatric oncologist caring for children, teens and young adults with sarcomas at Cleveland Clinic Children’s. He also serves a...

Mia is joined by OsteoWarriors Mackenzie, Sammy, and Sean to share their experiences with long-term side effects from osteosarcoma treatment. Nausea and hair loss are well-known side effects of chemotherapy - but what are some of the side effects that linger long after chemotherapy is over? Listen in on this frank discussion on why it can feel like cancer is never done with you. The group talks ab...

Dr. Amy LeBlanc is a board-certified veterinary oncologist, Senior Scientist and Director of the CCR Comparative Oncology Program at the National Cancer Institute, NIH. In this position, she directly oversees and manages the operations of the Comparative Oncology Trials Consortium (COTC), which designs and executes clinical trials of new cancer therapies in tumor-bearing pet dogs. She joins us on...

Sibylle Mittnacht, PhD discusses the current landscape of PARP inhibitor use in cancers and osteosarcoma and discusses preclinical evidence and translation of biomarker-driven use of therapeutics in osteosarcoma. Dr. Mittnacht heads the laboratory of Cancer Cell Signalling at the University College London (UCL) Cancer Institute, with a long-standing interest in concepts that drive tumour developme...