MIB Agents OsteoBites and osTEAo

In this episode of osTEAo, Sammy and Inaaya are joined by Elise, Sloane, and Camille for a conversation about self-advocacy and how it evolves after an osteosarcoma diagnosis. The group shares personal experiences navigating college, careers, travel, accessibility, and everyday life as survivors and individuals with disabilities. From campus accommodations to airport encounters, they discuss the c...

Osteosarcoma Webinar Series: Barbara VanHare from the Rare Cancer Research Foundation will discuss the key role patients can play in accelerating Osteosarcoma breakthroughs through the donation of excess tissue and clinical data. She will walk through current barriers in rare cancer research, why each patient's story and tissue is important and cover the different ways to participate, all at n...

Matteo Trucco, MD, joins us on OsteoBites to break down the scientific panels featured at the 2026 FACTOR conference. From clinical trials to the latest advances in osteosarcoma research, Dr. Trucco will guide attendees through the key themes and conversations shaping FACTOR 2026. Whether you are attending FACTOR for the first time or returning for another year, this preview is a great way to feel...

In this episode of osTEAo, OsteoWarriors share honest and personal reflections on the mental health challenges that can come with diagnosis, treatment, surgery, and survivorship. They talk about the fear, isolation, and loss of normalcy that often come with cancer, especially as young people trying to navigate school, relationships, identity, and everyday life at the same time. From struggling to...

David Shulman, MD, joins us on OsteoBites to discuss the newly opened phase 1/2 study to evaluate LNTH-2403, a LRRC15-targeted radiopharmaceutical, in patients with relapsed/refractory osteosarcoma. For many years, LRRC15 has been known to be an important target in osteosarcoma. A prior study showed a strong signal of activity of an LRRC15-targeted therapy in osteosarcoma; however, the development...

Andrew Clugston, PhD, a postdoctoral fellow in the Sweet-Cordero Lab at UCSF joins us on OsteoBites to discuss his OutSmarting Osteosarcoma funded work, in partnership with the RISE Foundation, on defining tumor-specific vulnerabilities by mapping oncogenic structural variation in osteosarcoma. The genomes of osteosarcoma (OS) cancer cells are among the most complex cancer genomes ever observed. I...

OsteoBites welcomes Caroline Maloney, MD, PhD, from the Medical College of Wisconsin, who will discuss her research on surgery-accelerated metastasis and developing perioperative therapies. Pulmonary metastasis remains the major cause of death in osteosarcoma. The timing of metastatic relapse defines clinically meaningful subgroups in osteosarcoma with patients who relapse within 6–12 months of su...

In this episode of osTEAo, the group explores how music is a powerful tool for coping with cancer - helping patients process emotions, find comfort during treatment, and stay connected to themselves and others. From meaningful song interpretations to personal stories of healing, the conversation highlights the impact of music. The episode also features a heartfelt farewell to co-host Mia as she re...

Philippos A. Costa, MD joins us on OsteoBites to introduce a Phase 2 clinical trial of zanzalintinib for people with osteosarcoma. The study is intended for patients who cannot receive standard chemotherapy or whose cancer has not responded to available treatments. The goal is to explore whether this therapy can control the disease while preserving quality of life during treatment. Philippos A. Co...

The Rao Lab at Seattle Children's Research Institute developed a three-dimensional (3D) tissue-engineered model of osteosarcoma to investigate the effects of the extracellular matrix on malignant cell function. The study demonstrated that culturing osteosarcoma (OS) cells within a 3D collagen matrix induced unique cellular responses, altered morphology, enhanced tumorigenic behavior, and reduc...

Osteosarcoma Webinar Series: Ali Cihan, PhD, a research scholar at Memorial Sloan Kettering Cancer Center, will discuss his OutSmarting Osteosarcoma funded work on targeting EPHA2 with dual-armored CAR T cells for immunotherapy in pediatric osteosarcoma. Dr. Ali Cihan is a research scholar at Memorial Sloan Kettering Cancer Center, where he focuses on immunotherapy with a particular emphasis on ad...

Dr. Aafrin Pettiwala from UCSF joins us on OsteoBites to discuss her OutSmarting Osteosarcoma funded work on identifying mechanisms of chemoresistance in metastatic osteosarcoma using molecular barcoding. The presentation covers how intratumoral heterogeneity drives chemoresistance and metastasis in osteosarcoma by using lineage tracing (CaTCH) and patient-derived xenograft models. She has identif...

Amy LeBlanc, DVM, a board-certified veterinary oncologist, Senior Scientist, and the Director of the intramural NCI’s Comparative Oncology Program, will review canine osteosarcoma and the clinical, biologic, and molecular features that make it a relevant animal-patient model for humans. She will share new data from the NCI's Comparative Oncology Program regarding MYC, and its value as a predic...

Osteosarcoma Webinar Series: Corey Weistuch, PhD, an Assistant Attending Physicist in the Service for Predictive Informatics within the Department of Medical Physics at Memorial Sloan Kettering Cancer Center, will discuss his OutSmarting Osteosarcoma funded work on implementing personalized, adaptive therapies in osteosarcoma. Corey Weistuch, PhD, is an Assistant Attending Physicist in the Service...

This episode of osTEAo focuses on the sibling side of cancer—celebrating the strength and support siblings bring to their families, and uplifting those who have lost a sibling and continue showing up every day. As the family focuses shift toward treatment and recovery, siblings often carry things quietly, finding ways to support through hospital visits, shared laughs, and simply being there. This...

Osteosarcoma Webinar Series: David Ulmert, MD, PhD, an Associate Professor at UCLA, discusses his OutSmarting Osteosarcoma funded work (Because of Sydney) on high-throughput characterization of pathobiological responses in osteosarcoma tumors treated with LRRC15-targeted radiotherapy to uncover curative co-treatment approaches. Dr. Ulmert will discuss his lab's work investigating how osteosarc...

The first episode of 2026 keeps it real about what the New Year actually feels like when osteosarcoma is still part of everyday life. Mia and Sammy are joined by Sloane and Mackenzie to talk through pain, recovery, scans, insurance stress, and the emotional weight January can bring. There’s no pressure to have it all figured out—just honest conversation, shared experiences, and hope focused on sma...

Osteosarcoma Webinar Series: Joseph Skeate, PhD, an Assistant Professor at the University of Minnesota, discusses his OutSmarting Osteosarcoma funded work  (Because of Annaleigh)  on next generation dual-CAR gamma delta T cells for the treatment of pediatric osteosarcoma. In this presentation, Dr. Skeate will provide an overview of the next-generation genome engineering strategies deployed for thi...

Osteosarcoma Webinar Series: Izuchukwu Ibe, MD, a musculoskeletal oncologist, Associate Professor, and Residency Program Director at the University of Mississippi Medical Center joins us on OsteoBites to discuss insights and highlights from the Musculoskeletal Tumor Society (MSTS) December 2025 Annual Meeting, December 3-5 in Mexico City. Dr. Ibe is a Musculoskeletal Oncologist with a residency fr...

Results of a phase II trial of olaparib in combination with ceralasertib in patients with recurrent and unresectable osteosarcoma Osteosarcoma Webinar Series: Katie Janeway, MD and Suzanne Forrest, MD join us on OsteoBites to discuss results of a phase II trial of olaparib in combination with ceralasertib in patients with recurrent and unresectable osteosarcoma. Dr. Janeway received her MD and MMS...

Osteosarcoma Webinar Series: Isidro Cortés-Ciriano will discuss his work studying how ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution.

In this episode of osTEAo, Mia and Sammy — joined by Mackenzie and Alejandro — open up about the many forms of loss: losing friends, losing health, and losing parts of themselves as life shifts after cancer. They talk about how grief shows up in changing abilities, in memories, and in the quiet moments where life feels different than before. Through honest conversation about rituals, storytelling,...

Osteosarcoma Webinar Series: Janeala Morsby, PhD, a postdoctoral associate at St. Jude Children’s Research Hospital, discusses her OutSmarting Osteosarcoma funded work focused on exploring the mechanism of synergy of the dual inhibition of ATM and PARP for the treatment of pediatric osteosarcoma. Janeala Morsby hails from the beautiful island of Jamaica, where she was born and raised in Port Anton...

Dr. Kelly Makielski and Dr. Jaime Modiano from the University of Minnesota join us on OsteoBites to discuss comparative extracellular vesicle (EV) biomarkers for osteosarcoma risk and prognosis. They are investigating extracellular vesicle (EV) transcriptomic profiles as minimally invasive biomarkers in canine and pediatric osteosarcoma in two ongoing studies. In the Canine Osteosarcoma Early Dete...

This one’s for anyone who’s ever had a hospital night that felt straight out of a horror movie. In Spooky Sarcoma Stories, four young osteosarcoma survivors — Sammy, Alejandro, Inaaya, and Max swap their wildest, scariest, and most surreal treatment memories, like the time Alejandro thought the IV tower was a robot monster, Max’s feeding tube removal turned into a “murder mystery,” Inaaya woke up...