Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

In this episode of The Histamine Well Podcast, Joanne explores how candida, yeast, and fungal overgrowth can worsen histamine intolerance and trigger ongoing mast cell symptoms. She explains how fungal-driven gut inflammation increases histamine production by activating mast cells, upregulating histidine decarboxylase (HDC), and reducing DAO enzyme activity — making it harder for the body to break...

In this short Clarity Session Q&A bonus episode of The Histamine Well Podcast , Joanne explains what antihistamines actually do, why symptoms often return when you stop them, and the common root causes behind histamine issues. Learn the difference between symptom suppression and true regulation of the gut, detox pathways, and nervous system.  ✨ Want more? Follow on Instagram , Facebook , and...

In this episode of the Histamine Well Podcast, Joanne speaks with Rachel Scott, who developed severe food intolerances, intense histamine reactions, and unexplained chronic symptoms following mold exposure. After years of misdiagnosis and treatments that failed to address the root cause, Rachel’s health continued to deteriorate — until a simpler, more balanced approach was introduced. Rachel share...

In this Clarity Session, Joanne breaks down a common myth about the MTHFR gene, methylation, and detox. Does having an MTHFR variant mean your detox pathways are impaired? Learn how detoxification really works, how methylation fits in, and what actually supports healthy histamine balance, gut health, and energy. Perfect for anyone navigating MTHFR, chronic fatigue, or food sensitivities.  ✨ Want...

In this episode of The Histamine Well Podcast , Joanne takes a deep dive into MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci) —a frequently overlooked bacterial colonization that can drive chronic inflammation, histamine intolerance, and persistent, unexplained symptoms . Joanne explains how MARCoNS colonize the nasal passages , often in the context of mould-related illnes...

In this episode of The Histamine Well Podcast, Joanne is joined by scientist James Bradshaw for an in-depth discussion on Vitamin B12 and its critical role in human health. Together, they unpack the complex biochemistry of Vitamin B12, exploring how it supports methylation pathways, homocysteine metabolism, and neurological function. This episode provides clarity on why Vitamin B12 deficiency is o...

In this episode of the Histamine Well Podcast, Joanne Kennedy explains why over-methylation is becoming increasingly common, especially among women, and how it’s closely linked to COMT enzyme activity, estrogen dominance, mood disorders, and inflammation. This episode breaks down the biochemistry of methylation in a clear, practical way—exploring how estrogen affects COMT, why some people react ba...

Are your hormones out of balance? In this episode of The Histamine Well Podcast , Joanne sits down with Rachel Schaefer, founder of Ginkgo Integrative Medicine , to demystify perimenopause and the role of Hormone Replacement Therapy (HRT) in supporting women’s health. They explore what actually happens during hormone fluctuations in perimenopause, how to recognize estrogen dominance, and the benef...

Is your home secretly affecting your health? In this episode of The Histamine Well Podcast , Joanne’s colleague Melanie Peers sits down with Building Biologist Jo Lia to uncover the hidden dangers of mold, electromagnetic fields (EMF), and poor indoor air quality. Jo shares her journey into building biology and explains how unseen environmental factors—like hidden mold spores or constant EMF expos...

In this episode of The Histamine Well Podcast ,  Joanne sits down with Rosaria Nithart, a French-based naturopath specializing in digestive health, to uncover the complexities of Hydrogen Sulfide SIBO—one of the most misunderstood forms of Small Intestinal Bacterial Overgrowth (SIBO). Together, they break down how Hydrogen Sulfide SIBO differs from hydrogen- and methane-dominant SIBO, exploring th...

In this episode of The Histamine Well Podcast , Joanne Kennedy sits down with physiotherapist and neuro-rehabilitation specialist Jacqui Raadschelders to explore the link between nervous system dysregulation and chronic illness. You’ll learn how the limbic system, vagus nerve, neuroplasticity, and brain retraining techniques play a vital role in recovery from conditions influenced by trauma, mold...

In this episode of The Histamine Well Podcast , Joanne is joined by colleague Melanie and patient Tracy, who shares her powerful story of navigating the challenges of oxalates, histamine intolerance, adrenal fatigue, and blood sugar imbalances. Tracy’s journey highlights the complex relationship between oxalates, adrenal and blood sugar imbalances, and oxalate dumping symptoms. With support from M...

In this episode of The Histamine Well Podcast , host Joanne Kennedy and guest Mariella Gebhardt unpack the nuances of medical testing in functional medicine—and why lab results alone don’t always tell the full story. From histamine intolerance and methylation issues to gut health, Candida, mold exposure, and hormone imbalances, Joanne and Mariela explore the limitations and benefits of testing whi...

Could mold be the missing link in your chronic health puzzle? In this episode of The Histamine Well Podcast , Joanne speaks with Melanie Peers about the hidden impact of mold illness and how it can silently drive histamine intolerance, food sensitivities, and long-term inflammation. You’ll discover how mold exposure can: Raise histamine levels and trigger mast cell activation Disrupt methylation a...

Perimenopause isn’t just a physical transition — it’s an emotional, spiritual, and energetic shift. In this empowering episode of The Histamine Well Podcast, Joanne speaks with Claire Tait, a holistic kinesiologist and intuitive energy healer, about how to navigate perimenopause with greater balance, calm, and self-awareness. Claire shares her expertise on how kinesiology, reiki, acupressure, yoga...

Can histamine be the hidden reason behind your anxiety? In this episode, I break down how histamine acts as a neurotransmitter in the brain — and why an overload can leave you wired, anxious, and unable to relax. We dive into how methylation, estrogen, mold, and gut inflammation (including SIBO and oxalates) all feed into the histamine-anxiety loop. Whether you're a practitioner treating pati...

We break down how disrupted sulfur metabolism can mimic histamine symptoms—severe bloating, crushing fatigue, joint pain, brain fog, skin flushing—and why reactions to garlic, onions, eggs, brassicas, NAC, and glutathione are key clues. You’ll learn the roles of sulfite/sulfide vs. sulfate , SUOX + molybdenum , B12, mitochondria, hydrogen sulfide overgrowth, and environmental drivers like mold and...

In this deeply personal and powerful episode, Joanne sits down with patient Anastasia Lamont to explore her journey through PMDD (Premenstrual Dysphoric Disorder), histamine intolerance, and overmethylation. Anastasia opens up about the debilitating symptoms she endured — from suicidal ideation and extreme fatigue to chronic pain and severe skin conditions — and how her life transformed through ta...

Struggling with persistent SIBO symptoms or unsure where to start with natural treatment? In this episode, I break down exactly how I treat SIBO in clinic — from diet and herbs to overlooked factors like biofilm, enzymes, histamine, and oxalates. Whether you're a health practitioner, student, or someone personally dealing with SIBO, you'll walk away with a deep understanding of the step-...

In this episode of The Histamine Well , we're diving into one of the most overlooked root causes behind symptoms like fatigue, histamine intolerance, hormonal imbalance, oxalate sensitivity, mood swings, and chronic inflammation: acid load and mineral depletion. You'll learn: Where acidity in the body comes from — from diet and inflammation to mitochondrial dysfunction and gut dysbiosis...

In this episode of The Histamine Well , Joanne dives deep into Premenstrual Dysphoric Disorder (PMDD) and severe PMS — the kind that can leave you feeling anxious, depressed, exhausted, and unlike yourself for half the month. Joanne shares insights from her clinical practice to explore what’s really going on beneath the surface, including: Hormone imbalances like estrogen dominance and low progest...

In this episode of The Histamine Well , host Joanne speaks with Amanda Bradshaw, co-founder of Mood Sense, to explore the critical role methylation plays in mood, mental health, and hormonal transitions like perimenopause. Joanne shares her clinical insights and surprising test results showing that some patients assumed to be under-methylators were actually over-methylating—changing the course of...

In this episode, Joanne Kennedy discusses a comprehensive case study of a patient with various symptoms like abdominal pain, migraines, and joint pain who was incorrectly suspected of having mold and oxalate problems. The root cause turned out to be gluten intolerance.  Joanne explains the impact of gluten on the immune system, highlighting how it can cause significant inflammation and histamine i...

In this episode of the Histamine Well Podcast , Joanne is joined by Amber Romanic, an expert in emotional eating, digestion, and hormonal health. Amber shares her personal journey overcoming emotional eating and discusses how it impacts gut health and increases histamine levels. They explore common emotional eating triggers, the role of high cortisol, and the pitfalls of extreme diets like intermi...

In this episode of the Histamine Well Podcast, Joanne explores the surprising link between high histamine levels and hypoglycemia.  She details how elevated histamine can disrupt blood sugar regulation through various mechanisms, including overstimulation of insulin production, suppression of glucagon, and cortisol dysregulation.  Joanne also offers practical advice on managing high histamine and...