Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Many people with flushing, hives, anxiety, brain fog, digestive issues, food sensitivities, and heart palpitations are told they have either histamine intolerance or Mast Cell Activation Syndrome (MCAS). While these conditions can look remarkably similar, they have very different underlying mechanisms—and understanding those differences is often the key to finding the right treatment. In this epis...

Many women enter their 40s expecting a few hormonal changes, but are often unprepared for the anxiety, sleep disturbances, fatigue, low mood, histamine symptoms, weight changes, and nervous system shifts that can accompany perimenopause. In this episode, Joanne shares her clinical and personal experience working with women through perimenopause and menopause, including her own journey with bioiden...

Methylation has become one of the hottest topics in functional medicine, biohacking, and wellness. From MTHFR testing to methylated supplements, many people are being told that boosting methylation is the key to better energy, mood, detoxification, hormone balance, and longevity. But what if more methylation isn't always better? In this episode, Joanne explores the science behind methylation,...

Could histamine be contributing to Premenstrual Dysphoric Disorder (PMDD)? In this episode of The Histamine Well Podcast, Joanne explores the growing interest in the connection between PMDD, histamine intolerance, mast cell activation, and hormonal fluctuations. As more women report improvements in PMDD symptoms with antihistamines, the question is gaining attention: could histamine be a missing p...

Persistent fatigue is one of the most common—and most frustrating—symptoms experienced by people with mould illness. Many find that despite sleeping more, resting, pacing themselves, and trying countless supplements, the exhaustion simply doesn't improve. In this episode of The Histamine Well Podcast , Joanne explores the hidden connection between mould illness and mitochondrial dysfunction,...

In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould mycotoxins and Small Intestinal Bacterial Overgrowth (SIBO) — and why so many people with chronic digestive symptoms may be missing the true root cause of their gut dysfunction. If you’ve been struggling with bloating, reflux, constipation, diarrhea, histamine intolerance, food sensitivities, nausea,...

What if your histamine symptoms aren’t just about food? In this episode of the The Histamine Well Podcast, Joanne explores the overlooked connection between bile flow, histamine intolerance, SIBO, estrogen dominance, mold exposure, oxalates, methylation, and chronic inflammation. Bile plays a critical role in digestion, detoxification, hormone clearance, and microbial balance in the gut. When bile...

Can methylated B vitamins make your symptoms worse instead of better? In this episode of The Histamine Well Podcast , Joanne explains the connection between high homocysteine, histamine intolerance, methylation, and why some people react poorly to methylated nutrients. High homocysteine is associated with cardiovascular disease, cognitive decline, inflammation, and neurological health concerns — y...

Can you take Calcium-D-Glucarate while on HRT estrogen during menopause? In this short Q&A episode of The Histamine Well Podcast , Joanne explores the relationship between estrogen detoxification, hormone replacement therapy (HRT), menopause, gut health, and histamine-related symptoms. Many women are advised to take supplements that support estrogen detox, but is this always the right approach...

In this episode of The Histamine Well, Joanne shares a powerful clinical case study exploring the connection between SIBO (Small Intestinal Bacterial Overgrowth), histamine intolerance, hormonal imbalance, estrogen dominance, gut health, bloating, acne, fatigue, and PMS symptoms. This episode follows the journey of a 37-year-old woman who experienced rapid body changes over two years — including u...

Can something as simple as an Epsom salt bath support detoxification, gut health, and nervous system regulation? In this Q&A episode of The Histamine Well Podcast , Joanne breaks down the clinical benefits behind Epsom salt baths (magnesium sulfate) —and why they’re often recommended for patients dealing with histamine intolerance, sulfur issues, chronic fatigue, and food sensitivities . You’l...

Are “healthy” foods like broccoli, garlic, eggs, or red meat making you feel worse instead of better? In this episode of The Histamine Well Podcast , Joanne breaks down one of the most overlooked root causes of food sensitivity, gut symptoms, and chronic fatigue: sulfur metabolism dysfunction. If you’ve been struggling with histamine intolerance, unexplained food reactions, bloating, brain fog, or...

Do you find your anxiety worsening at night—or waking you suddenly between 2AM and 4AM with a racing heart and intrusive thoughts? In this Clarity Session Q&A, Joanne explores one of the most common patterns seen in clinic: night-time anxiety and early morning wake-ups —and why this is often more than just a psychological issue. This episode explains the physiological root causes of anxiety at...

Are you struggling with anxiety, overwhelm, or constant nervous system dysregulation—despite normal lab results? In this episode of The Histamine Well Podcast , Joanne uncovers one of the most overlooked root causes of anxiety in women: blood sugar instability. Learn how blood sugar spikes and crashes can trigger cortisol and adrenaline, creating symptoms that feel exactly like anxiety disorders....

If your blood tests are “normal”… why do you still feel inflamed? In this Q&A Clarity Session of The Histamine Well Podcast , Joanne answers a deeply important and often overlooked question: why symptoms of inflammation can persist even when CRP and ESR markers come back normal . Many people are told everything is “fine” based on standard blood work—yet continue to experience fatigue, brain fo...

In this in-depth episode of The Histamine Well Podcast , Joanne explores why hormone symptoms often persist despite treatment, and what may be driving this beneath the surface. Drawing on clinical observation and biochemistry, Joanne explains how chronic inflammation, histamine dysregulation, and methylation imbalances interact to disrupt hormonal signaling, ovulation, and recovery. If you’ve trie...

Are bioidentical hormones truly “natural”—or is that just clever marketing? In this Q&A Clarity Session of The Histamine Well Podcast, Joanne breaks down one of the most common and misunderstood questions in women’s health: what bioidentical hormones actually are, where they come from, and how they differ from both synthetic hormones and herbal remedies. Many women exploring hormone replacemen...

Can’t tolerate HRT? This episode explores the connection between histamine intolerance, hormone replacement therapy (HRT), SIBO, gut health, menopause symptoms, and hormone imbalance in women. Joanne Kennedy shares a clinical case study showing how histamine overload and gut dysfunction can worsen HRT side effects like brain fog, fatigue, mood swings, and skin reactions. Learn how the estrogen-his...

In this Q&A Clarity Session of The Histamine Well Podcast , naturopath Joanne Kennedy explains the science behind sulforaphane and how it activates the NRF2 pathway , often referred to as the body’s “master switch” for protection and repair. Rather than acting as a simple antioxidant, sulforaphane works at a deeper level—helping to switch on a network of protective genes responsible for detoxi...

In this episode of The Histamine Well Podcast, Joanne speaks with nutritional biochemist Dr. Christine Houghton about the GEMM Protocol (Gut Ecology & Metabolic Modulation) — a science-based approach to restoring gut health by repairing the gut lining and activating protective genes. Learn how sulforaphane, NRF2 activation, and targeted microbiome support can help improve gut inflammation, his...

In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a common and often confusing question: Should I take antibiotics for SIBO? The truth is—it depends. In this episode, Joanne breaks down the two distinct patient scenarios she commonly sees in clinical practice. She explains when antibiotics may be a practical and supportive option, especially for those with lifestyle lim...

Is SIBO (Small Intestinal Bacterial Overgrowth) really the root cause of your bloating and food intolerances — or is it a downstream effect of deeper dysfunction? In this episode of The Histamine Well Podcast , Joanne explains why SIBO rarely develops in isolation and why antibiotics or herbal antimicrobials alone often fail to prevent relapse. If you’ve been stuck in the cycle of treating SIBO re...

In this Q&A episode, we explore how methylation affects mental health , including its impact on neurotransmitters like dopamine, serotonin, and norepinephrine. Learn how the methylation cycle regulates gene expression, hormone balance, histamine clearance, and stress resilience — and why low folate, vitamin B12, B6, and B2 can contribute to symptoms such as anxiety, depression, brain fog, fati...

In this episode of The Histamine Well Podcast , Joanne explains how Helicobacter pylori (H. pylori) can quietly drive histamine intolerance, SIBO, and hormone imbalance — even without classic ulcer or reflux symptoms. H. pylori produces urease, converting urea into ammonia and lowering stomach acid. This reduction in hydrochloric acid can impair protein digestion, weaken pathogen control, and disr...

In this short Clarity Session Q&A, Joanne explains the key differences between common magnesium forms and how to choose the right one for symptoms like anxiety, sleep issues, constipation, migraines, fatigue, muscle pain, or brain fog. Learn when each type may help—and when to avoid certain forms if you’re sensitive.  ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and t...