Healio Rheuminations

In this episode of Rheuminations, host Adam J. Brown, MD , will walk you through the history of pleural effusions in rheumatoid arthritis. He discusses topics ranging from fascinating case studies to how pleural effusions are treated today.  ·         Diving into pleural effusions. 2:38 ·         What's in the fluid? 12:01 ·         When did pleural effusions become linked to RA? 15:18 ·         T...

Not all jaw claudication is giant cell arteritis. Hear some interesting cases and learn about things to look for in the labs to suspect an alternative diagnosis along with co-host Leonard H. Calabrese, DO. ·         When GCA isn't GCA, walking through mimic cases 2:43 ·         Infectious mimics 14:36 ·         Large vessel involvement cases 16:47 ·         GCA as a medical emergency 22:05 ·      ...

In this week's episode we interview Kinanah Yaseen, MD, a rheumatologist from Cleveland Clinic's department of rheumatic and immunologic diseases about using ultrasound for giant cell arteritis. ·         Intro by Adam J. Brown, MD 0:12 ·         Dr. Brown's recent patient 1:34 ·         History of ultrasound and GCA 3:20 ·         Episode overview 7:05 ·         History of echolocation; how bats...

In this week's episode we interview Joseph Parambil, MD , staff member in the department of pulmonary, allergy and critical care medicine at Cleveland Clinic, about the current challenges of interstitial lung disease, or ILD. ·         Intro by Adam J. Brown, MD 0:12 ·         Welcome back Joseph Parambil, MD 0:32 ·         But first, some medical history on ILD 1:04 ·         ILD vs. IPF 2:26 ·  ...

This special edition episode features the latest installment of Healio Community's book club. Physician author Kevin J. Tracey, MD, discussed his book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes in which he explores the potential of stimulating the vagus nerve to treat rheumatoid arthritis and other diseases. ·         Intro by Adam J. Brown, MD 0:1...

To celebrate 101 episodes, I sit with Leonard H. Calabrese, DO, to discuss his unique career in Rheumatology, spanning immunology, HIV, MECFS, IRES, CNS vasculitis and more. We also discuss how medical history shaped our careers.  ·         Intro 0:12 ·         Welcome Leonard H. Calabrese, DO 3:11 ·         A quick friendship begins over medical history 4:14 ·         How Healio Rheuminations beg...

What does a goiter and syphilis have in common with the first descriptions of giant cell arteritis? Join us as we dive into the history of the most common type of vasculitis! Intro 0:13 GCA at ACR 2025 00:30 How Brown has approached framing this episode 1:01 A primer leading us to GCA 3:15 Let's get to the story 4:02 The man who couldn't wear a hat 4:57 Dr. Bayard Horton's 7:40 A tangent on cluste...

The story of rheumatoid factor could be a 10 minute episode, but in this episode, we dig deep into the history of the lab techniques leading up to this discovery…that happened twice.  Intro  0:15 Rheumatoid factor quick background and history  00:36 Rheumatology blood tests  3:02 What is Rheumatoid factor?  3:49 Spiderman and latex agglutination: Testing for rheumatoid factor  4:50 The double disc...

Active or not active, that is the question. In this week's episode we interview  Alexandra Villa-Forte, MD, MPH, a staff physician in the Center for Vasculitis Care and Research at Cleveland Clinic and a leading vasculitis expert, on a pragmatic approach to recognizing disease activity in patients with ANCA vasculitis. ·        Intro 0:01 ·        Welcome Alexandra Villa-Forte, MD, MPH 0:10 ·     ...

This special edition episode features the latest installment of Healio Community's book club. Physician author  Eric Topol, MD,  discusses his book,  Super Agers: An Evidence-Based Approach to Longevity ,   a guide to the science of living a long life free of debilitating diseases with Leonard H. Calabrese, DO,  chief medical editor of  Healio Rheumatology . ·         Intro by Adam J. Brown, MD 0:...

In this episode, we focus on the history of researchers discovering the clinical applicability of the IL 23/17 axis, with a particular emphasis on psoriasis, psoriatic arthritis and axial SpA Intro  0:15 In this episode  0:27 Leonard Calabrese, DO,  is listening!  1:07 Recap of last episode  3:23 Putting the pieces together  5:32 Quick overview of this science heavy episode  6:27 What is psoriasis...

In this episode, we dive into a two-part story of intrigue starting from a paradigm shift in understanding of T cell biology because of a mouse model of post-measles encephalopathy, to the eventual recognition of the IL-23/17 immune axis. •    Intro 0:01 •    In this episode 0:12  •    Interleukin-17 (IL-17) is a relatively recent discovery 1:34 •    The beginning of TH-17 2:20 •    Looking at aut...

In this episode, we dive into the history of polymyalgia rheumatica, how it was discovered and its link to giant cell arteritis. Intro 0:01 In this episode 0:10 What is polymyalgia rheumatica (PMR)? 0:24 The history of PMR 02:12 PMR in the 1950s: A formally recognized disease 04:52 What was probably PMR in the 1880s 06:27 Naming PMR: Senile rheumatic gout 07:26 1957: The witch's shot and finally l...

In the final part of this series, Joseph Parambil, MD, walks us through the approach of managing pulmonary hypertension, reviews the pathophysiology and digs into the mechanisms and the differences in the medications. Intro 0:12 In this episode 0:17 Interview with Joseph Parambil, MD 2:53 Reviewing and clarifying pathophysiology prior to initiating therapeutics 4:13 Evaluating patients in terms of...

In this episode, we dive into the early therapies and how our understanding of vascular physiology drastically changed the management of pulmonary hypertension. Intro 0:12 In this episode  0:18 Recap of part 1 & 2  0:31 What part 3 is about  2:31 WHO conference in 1975: Treating pulmonary hypertension  3:48 The Discovery of Non-Steroidal Anti-inflammatory Drugs (NSAIDs), Part 1   5:20 Epoprostenol...

In part 2, we dig into the history of pulmonary hypertension. How did this strange diagnosis first get recognized, what does it have to do with cows with thick necks and urinary catheters in the heart? Intro 0:11 In this episode  0:17 Recap of part 1 0:26 How was pulmonary hypertension discovered? 2:38 1891  3:51 1901 5:07 1935 7:02 Hilar dance  12:58 Cardiac catheterization: 1929  15:03 When did...

In this series, we dive into what rheumatologists should know about pulmonary hypertension, starting an interview with Joseph Parambil, MD, where we learn about the disease, when to suspect and how to work up! Intro 0:11 In this episode  0:16 Preview of the four-part series  4:46 Interview with Joseph Parambil, MD 6:27 How did you become interested in pulmonary hypertension? 7:02 Brown and Parambi...

On this episode, hear the 2024 updates on COVID-19, long COVID and the latest developments in research in rheumatology. Hosted by Dr. Leonard Calabrese. Intro 0:12 In this episode 0:21 Coming up on Healio Rheuminations  0:56 COVID-19, long COVID and the rheumatologist with Leonard Calabrese, DO 2:19 Questions  3:12 Long COVID  4:46 Calabrese's bias  10:15 The evidence  13:08 Auto antibodies  14:54...

It's that time of year again, everyone rolling up their sleeves to get a flu shot. This throwback episode dives into the history of the struggles pinning down the causative agent of flu and the journey to the vaccine! Intro 0:40 In this episode 1:11 The history of the flu: 1892 1:41 What do we know about viruses? 6:29   Rabies and dead virus 11:17 A Sickness in the Serum, Part 2 14:43 1918 16:44 V...

In the third episode of the NSAIDs saga, we focus on COX-2 inhibition! Did the hopes and dreams of selective COX-2 inhibition pan out? What can the rise and fall of VIOXX teach us about physiology? Intro 0:11 Recap of part 1 & 2  0:28 In this episode  1:44 Cyclooxygenase 2 (COX-2) and the rat experiment  3:12 What do we know about the prostaglandins? And what about COX-2  7:54 What does prostacycl...

In this episode, we dive into the story of aspirin and the development of ibuprofen, ending with the experiments that showed the mechanism of how aspirin actually works. Intro 0:12 Review of part 1 0:28 In this episode 1:04 Blocking prostaglandins and willow leaves  2:26 Edward Stone 3:45 Johann Andreas Buchner 4:16 The chemical structure of salicylic acid and creating the synthetic compound  4:44...

Humans have had an insatiable appetite for inhibiting production of prostaglandins for centuries! This series delves into the history of aspirin and NSAIDs, looking at the understanding of the prostaglandin pathway. ·        Intro 0:12 ·        In this episode 0:23 ·        What are NSAIDs? 0:53 ·        Prostaglandins 5:50 ·        What are prostaglandins? 7:19 ·        Where do prostaglandins co...

This episode digs into the pathophysiology of urticaria vasculitis from anti-C1q to the story of bradykinin. ·        Intro 0:11 ·        In this episode 0:22 ·        Review of episode 83 1:23 ·        Listen to previous episode, The Complement System for Dunces 4:09 ·        Anti-C1q antibodies 6:26 ·        Lupus, anti-C1q and lupus nephritis 9:33 ·        What happens when you inject anti-C1q...

Is it an allergy or an autoimmune vasculitis, or a little of both? Find out the story of urticarial vasculitis, how this disease was recognized and eventually sorted out from other types of urticaria. ·        Intro 0:12 ·        In this episode 0:21 ·        Case study 1:22 ·        Chronic spontaneous urticaria, hives and nettles 7:57 ·        Dermatographism and witchcraft? 10:15 ·        Cause...

What should rheumatologists know about what we've learned about COVID-19 and long COVID in 2023? Hosted by Dr. Leonard Calabrese. ·        Intro 0:11 ·        In this episode 0:21 ·        2023: current status and controversies 0:35 ·        What is going on with COVID-19? 01:53 ·        What do we know about vaccine responses? What should we be telling our patients about vaccines in our immunocom...