Healio Rheuminations

It's that time of year again, everyone rolling up their sleeves to get a flu shot. This episode dives into the history of the struggles pinning down the causative agent of flu and the journey to the vaccine! ·        Intro 0:12 ·        In this episode 0:17 ·        The history of the flu: 1892 3:10 ·        Rabies and dead virus 10:52 ·        A Sickness in the Serum, Part 2 14:31 ·        Vaccin...

What is silica? How does it impact your risk of developing autoimmunity if you inhale it, inject it or even snort it up your nose? Listen and find out! ·        Intro 0:12 ·        In the previous episodes 0:28 ·        The Ajax incident of 1979 1:15 ·        Silica and its association with autoimmune disease 4:11 ·        The history of silica and the health risks 5:21 ·        Rheumatoid sclerod...

In this episode, we dig through the data of lupus in Africa and speak with experts on the Lupus Gradient, the impact of malaria and what we can learn from it all. ·        Intro 0:12 ·        In the previous episode 0:30 ·        Lupus Gradient 2:01 ·        Back to Dr. Brian Greenwood 3:48 ·        Polyarthritis 4:04 ·        Rates of autoimmune diseases 6:00 ·        Malaria and mouse models 7:3...

This episode delves into what we can learn about the impact of the environment on autoimmunity, digging into how rates of autoimmunity can vary drastically in different parts of the world. ·        Intro 0:12 ·        In this episode 0:16 ·        Dr. Brian Greenwood 0:22 ·        The geography of autoimmunity 7:01 ·        Type 1 diabetes 10:31 ·        Finland and type 1 diabetes 13:57 ·       ...

This episode delves into the history of the hygiene hypothesis. What do we know about different exposures changing risk for asthma and allergies, and do these exposures have the same protection for autoimmunity? ·        Intro 0:12 ·        In this episode 0:18 ·        Hygiene hypothesis 0:33 ·        Allergic rhinitis (or Hay fever) 2:32 ·        Pollen and the allergy skin test 8:58 ·        Ex...

On this special episode of Rheuminations, I interview comedian and ophthalmologist  William Flanary, MD, and Kristin Flanary , also known as the Glaucomfleckens, on hypermobility and physician burnout. Kristen Flanary highlights what it's like to live with hypermobility, and Dr. William Flanary discusses his thoughts on physician burnout and using their podcast, Knock Knock, Hi , as comedy relief....

Was your psoriasis caused by the Black Death? Learn more than you might have wanted to know about the Black Death and delve into the data on the immunologic/autoimmune ramifications of wiping out nearly half of Europe. ·        Intro 0:11 ·        In this episode 1:09 ·        The Black Death 1:24 ·        The History of IV Immunoglobulin episode 2:07 ·        How the Black Death happened 4:07 ·  ...

In this episode we explore ways in which the extracellular matrix can be manipulated, including the story of doxycycline, TGF-beta in Marfan syndrome and whether beta blockers can reduce vascular events in vascular EDS. ·         Intro 0:12 ·         Review of previous episode 0:28 ·         In this episode 2:26 ·         The pressure against the vessels 4:06 ·         The pressure against the wal...

Dive into vascular Ehlers-Danlos syndrome. What is it? How does it present? Get clues to its diagnosis and learn more about collagen than you ever wanted to know. Intro 0:12 In this episode 0:17 Why vascular Ehlers-Danlos syndrome? 0:28 Case study: Dr. Mories 2:20 What can we learn about vascular Ehlers-Danlos syndrome? 05:02 Collagen and elastin 05:57 Collagen: horses and glue 07:07 More about co...

In this episode, Dr. Benjamin Claytor walks us through his approach to suspected sensory ganglionopathies. I also cover other neurologic complications of Sjogren's syndrome and some interesting history on vitamin B6. Intro 0:12 In this episode 0:46 Neurologic complications of Sjogren's Syndrome 1:55 Intro of Dr. Benjamin Claytor 6:00 The interview 6:49 Case study: process of diagnosis 7:17 Dorsal...

A sensational (or lack thereof) series on the signs and symptoms of the spellbinding sensory ganglionopathies. Intro :12 Today's episode :16 Anatomy review 1:32 Large fiber vs. small fiber nerves 4:47 Case presentation 6:11 Neurologic examination of patient 8:31 What is pseudoathetoid posturing? 10:11 What does it mean to be length independent? 14:30 What is sensory ganglionopathy? 16:19 How did t...

In part two, Leonard Calabrese, DO, discusses the symptoms of long COVID and the role that rheumatologists play in diagnosing and treating patients with long COVID. Brought to you by Tremfya. Intro 1:06 Calabrese introduction 1:11 In this episode 1:36 Defining long COVID 1:49 Reviewing symptoms of long COVID 2:51 Long COVID fatigue 3:44 Studies and research on fatiguability 4:38 Phenomena of post-...

In this episode, Leonard Calabrese, DO, reviews the history and controversies of post-infection sequelae, as well as the facts and epidemiology of long COVID. Intro :12 Calabrese introduction :15 COVID-19 and the history of modern medicine :48 In this episode 1:39 The course of COVID-19 2:05 COVID-19 vaccines and immunity 2:50 Controversy, facts, fascination, long COVID 3:16 The history of post-ac...

How is the synovial fluid produced? Who figured it out? It's a ripping yarn involving corpses, cats, anti-hypertensives, steroids and streptococcus. Brought to you by Tremfya. Intro :11 Today's episode :15 Synovium 101 :22 Overview of the synovium and synovial fluid 2:06 How they figured it out? Dr. Marian Ropes 5:37 Investigating synovial fluid 7:46 Cows experiment and where synovial fluid comes...

What does the PAPA spectrum disorder teach us about SAPHO? Is SAPHO an autoinflammatory condition or part of the SpA spectrum? Why have antibiotics been used to treat this condition? Find out in this episode! Brought to you by Tremfya. Intro :01 Welcome to another exciting episode of Rheuminations :11 About today's episode :17 A summary of SAPHO Part 1 :24 What to expect in this episode 1:28 Earli...

What is SAPHO? What does the 'H' stand for, again? This episode explores some basics about the condition and delves into the history of how this disease came to be. Intro :01 Welcome to another exciting episode of Rheuminations :11 About today's episode :17 What does the acronym 'SAPHO' stand for? :37 How do you define this condition? 2:35 So, what is SAPHO syndrome? 4:59 Are any of the letters sp...

Glucocorticoids can do a lot of harm over time. In this episode, John Stone, MD, MPH, walks us through the Glucocorticoid Toxicity Index (GTI), a validated tool to measure steroid toxicity over time that we'll be seeing more of in the future. Intro :11 Stone introduction :26 About the GTI 1:13 Professional development opportunities for rheumatologists 2:32 The interview 4:27 What is the GTI, how d...

In this episode, Cassandra Calabrese, DO, dual-boarded in infectious disease and rheumatology, walks us through when to suspect Bartonella (it's not always a house cat!), how to diagnose and how to treat. Intro :01 Welcome to another exciting episode of Rheuminations :11 About today's episode :17 10th Annual Basic and Clinical Immunology for Busy Clinicians starts 2/26 2:18 A look at upcoming epis...

Is this episode clinically relevant? No. Is it important? I think so! The story of Bartonella features a cast of characters, including a medical student who died trying to understand the disease, as well as some scientists with some less than ethical experiments. Enjoy! Intro :01 Welcome to another exciting episode of Rheuminations :11 About today's episode 1:12 More discussion of Bartonella quint...

Bartonella is an important mimic of a variety of autoimmune diseases, and it can be subtle. This episode tackles the ways in which this strange organism can present to a rheumatologist. Brought to you by Genentech Intro :01 Today's episode :15 Overview of Bartonella 1:57 Inspiration for this episode 4:17 Bartonella, what are you? 7:24 About Bartonella quintana 12:32 Take-away so far 16:07 Core sym...

What is Paget's? Why is it declining across much of the globe? Find out, plus hear an interview with the head of the center for osteoporosis and metabolic bone disease at Cleveland Clinic, Chad Deal, MD . Brought to you by GSK. Intro :11 Today's episode :27 What is Paget's? 1:07 The history of Paget's 5:35 How often is this symptomatic? 9:30 The epidemiology of Paget's 13:22 The data on viruses an...

The final episode in this trilogy delves into the advancement in laboratory techniques that allowed for more accurate measurements of immune complexes, leading to studies in the '50 and '60s that clearly demonstrated the potential pathogenicity of immune complex-mediated disease.   Brought to you by GSK. Intro :20 Recap and in this episode :40 The precipitant reaction 3:29 The antibody story 11:25...

The second episode in the series delves into the experiments and observations of Dr. Clemens (Baron) von Pirquet who first proposed that antibodies and antigens join forces to wreak havoc.   Brought to you by GSK. Intro :10 Today's episode :26 A recap of the previous episode :43 About Baron von Pirquet 4:40 What's going on in the study of infectious disease and immunology in the early 1900s? 6:41...

This episode delves into the clinical presentation of serum sickness along with a dash of Arthus reaction, to boot! Brought to you by GSK. Intro :10 Today's episode :26 Let's get into some cases 4:11 The Arthus reaction 6:06 What is another example of the same thing happening but on a systemic level? 7:25 Breaking down the clinical features of serum sickness 14:20 How confident are we that the com...

Why is hemochromatosis so common? What is iron actually doing to the joint? Does phlebotomy help? What's going on with iron and Popeye? These are the questions we tackle in the second episode of hemochromatosis: Iron and Bone! Brought to you by GSK. Intro :19 Today's episode :29 Why is hemochromatosis so common? 1:06 The history of Popeye the Sailor Man 3:37 Treatment with phlebotomy 8:35 Why does...