The Macro Perspective

In this episode of The Macro Perspective, Marcos and Seamus cover Oral GLPs: why aren’t oral GLP-1 medications as popular as injectables? They cover bioavailability, stomach acid, liver effects, cost, and trial data showing more GI side effects with orals. They also cover the “pill burden” and the dosing rules for orals, like fasting and waiting 30 minutes. From there they move on to nasal peptide...

On this episode of The Macro Perspective, Seamus and Marcos talk with Evan Boydstun of Geviti about gut health. Evan shares how extreme habits, from a 100,000-pull-up challenge to a macro-obsessed diet and a gallon of raw milk a day, led to dysbiosis and flatlined cortisol. He also reads Marcos’s wife’s GI-MAP stool test live on screen. His main advice for the type-A, over-trained crowd: take rest...

Intro: Biohacking is everywhere, but are we optimizing before we’ve nailed the basics? Marcos and Seamus unpack the backlash around peptides, GLP-1s, wearables, and tracking, and ask when these tools help versus when they become another source of pressure. They make the case for simpler, more sustainable health built on what actually works. Timestamps 00:00 Biohacking backlash 02:05 Defining bioha...

In this roundtable episode, Marcos and Seamus talk with Ryan and Evynn O’Leary of Evryday Club about building a social brand around interviews with older adults who stay active and strong. They explore how a spontaneous gym interview became a viral hit, what goes into making content people want to share, and how authenticity, persistence, and community can matter more than perfection. The conversa...

Ketones are moving from niche biohacking circles into the mainstream. Michael Brandt, CEO and co-founder of KetoneIQ, joins to explain how he built a new category—and why ketones may have a role beyond sports performance. Michael traces his path from Stanford and YouTube to the run that sparked KetoneIQ, breaking down ketones as an energy source, how they differ from caffeine, and why he calls the...

George Wiseman joins Marcos and Seamus to discuss invention, mechanical problem-solving, and Brown's gas. The conversation traces Wiseman's path from fuel-efficiency experiments to claims about hydrogen therapy, with the hosts pressing on the science, safety, and need for further research behind Brown’s Gas. Timestamps: 00:00 — Guest Introduction 01:32 — Ranch Origin Story 03:57 — Early Mileage Re...

Marcos and Seamus sit down with Stephen Olson of Benchmark Body Metrics to dig into VO2 max testing, metabolic carts, DEXA scans, blood work, and wearable accuracy. Stephen breaks down what VO2 testing can and cannot tell us, why protocols should be individualized, and what his sauna experiments revealed about metabolism. They also cover aerobic base training, zone two, and why the right data help...

Marcos and Seamus dig into CrowdHealth, the fast-growing healthcare crowdfunding model marketing itself as a secular, for-profit alternative to both traditional insurance and faith-based health shares. From $300 specialist bills to a $32,000 NICU stay, they stress-test the model against real financial stakes — and ask the question most people avoid until it's too late: are you actually buying prot...

Marcos and Seamus break down how social media inflates fitness standards, why "average" now feels low, and why comparing yourself to your past self beats comparing yourself to the algorithm. Timestamps 00:00 - Defining fitflation 01:20 - Weight gain, body image 03:10 - Attention economy content 04:05 - Idealized aesthetic creation 05:03 - Content triggers action 05:31 - Image becomes product 05:53...

Eli Lilly has filed lawsuits against multiple US companies for allegedly selling black market retatrutide and counterfeit GLP products, even before the drug's official 2027 launch. Marcos Rivera and Seamus break down what's driving gray market demand, and why the bigger story isn't the drug itself, it's what health, aesthetics, insurance incentives, and social media are shaping people to believe "...

When big companies buy trusted health and food brands…Thorne, Primal Kitchen, RXBAR, Perfect Bar, Pure Encapsulations…what actually changes? Seamus and Marcos dig into how scaling shifts size, taste, texture, and trust even when the branding doesn't. They cover label transparency, pricing psychology, and the tradeoffs between convenience, quality, and cost, closing with a simple takeaway: know wha...

In this episode, Marcos and Seamus are joined by Dr. Lauren Colenso-Semple, PhD in Integrative Physiology and Certified Strength & Conditioning Specialist. She's a researcher and science communicator specializing in female physiology, exercise, and nutrition, with extensive hands-on experience helping hundreds of women through every stage of life. Dr. Colenso-Semple co-owns the MASS Research R...

In this episode, Seamus is joined by Giovanni Vaccaro for a conversation on mindset, confidence, and optimizing life. Giovanni is co-founder of Glamsquad, the on-demand beauty platform operating in 15 cities nationwide, connecting 2,000+ pro beauty artists and delivering nearly 2 million services. He's also the founder of Peak Mode, a coaching system helping founders and executives lead with more...

In this episode, Marcos and Seamus sit down with Ryan Glatt, MS, CPT, NBC-HWC, Director of the FitBrain℠ Program at the Pacific Neuroscience Institute, to explore how exercise, coaching, and neuroscience can work together to support lifelong brain health. Ryan shares how his personal experience with concussion recovery and movement-based gaming led him into the field of brain health, and how that...

In this episode, Marcos Rivera and Seamus unpack the rising cost of “proteinified” foods and why whole foods may still be the better value for most people. They also dig into how much protein you actually need, how to hit it without overcomplicating your diet, and why weekly macro tracking may be more sustainable than obsessing over daily precision. Timestamps: 0:06 — Intro 2:25 — nutrition trends...

In episode 209, Marcos and Seamus explore how emotional regulation enhances performance across sports, work, and personal life. Timestamps: 00:00 - Introduction 00:30 - Reflecting on six years since the pandemic  02:00 - Personal stories of loss during the pandemic 04:00 - How the pandemic changed our access to loved ones  07:00 - Metaphor of mountain climbing  09:15 - The highs and lows of reachi...

Episode 208 explores the normalization of performance-enhancing drugs, peptides, and hormone optimization in the fitness and youth culture. It discusses the implications, safety, accessibility, and future trends of these substances, emphasizing the importance of informed decisions and bodily autonomy. Chapters 00:00 Introduction and Overview of the Podcast 01:12 The Normalization of Steroid Use Am...

Gut health isn’t just about what you eat. 👀 In Episode 207 of The Macro Perspective , Marcos and Seamus unpack the many factors that can affect digestion—from training intensity and stress to sleep, supplements, food choices, and recovery. Four takeaways from the episode: 🧠 Stress management should be part of every gut-health protocol. 💪 More intensity isn’t always better—your training could be...

🥙🥑Hypnosis for Permanent Weight Loss with Leslie Thornton, Ep 206 🥩🍠 Most people think lasting weight loss starts with eating less or exercising more. What if it actually starts by changing what your subconscious believes? This week on The Macro Perspective Podcast, we sat down with Leslie Thornton—founder of Hypnosis for Permanent Weight Loss—to unpack why so many high-achieving people can su...

Power In Movement | Ep. 205 with Dr. Grace Schwemmer 💥 Pain doesn't mean you have to stop moving—it means you need a better plan. In this episode, physical therapist and strength coach Dr. Grace Schwemmer breaks down how to train smarter, recover better, and build a body that's resilient for life—not just for your next workout. 🔥 Top takeaways: ⚡ Your body adapts to the stress you consi...

🤫Silent Moves, Loud Results 🗣️ with Kris Rugolski, Ep 204  What does it take to become a Hyrox World Champion, run 100-mile races, and compete among the best in the world... while still working a full-time job? This week, we sat down with Kris Rugloski, one of the most accomplished endurance athletes on the planet, and her answers might surprise you. 🔥 Being a world champion changes less than yo...

🎙️ Episode 203: Slow Is Fast with Greg Casey What if the fastest way to get where you want to go... is to slow down? In this episode, we sit down with coach, cancer survivor, artist, father, and  motivationalist Greg Casey. From overcoming multiple cancer diagnoses to building deep relationships through coaching, Greg shares the lessons that have shaped his philosophy on life, fitness, resilience,...

EPISODE 202: SCIENCE COMMUNICATION WITH DR. ERIC HELMS 🚨 What if the biggest problem in health and fitness today isn't misinformation... it's not knowing who to trust? This week on The Macro Perspective Podcast, we sat down with Dr. Eric Helms—researcher, coach, science communicator, co-founder of 3DMJ and MASS Research Review, author of the Muscle & Strength Pyramids, and one of the...

EPISODE 201: WOLF PACK WITH JOHN WOLF 🐺 Coach John Wolf has been shaping the way people train for years — long before most of it was mainstream. His approach has always been a little different…Less about chasing numbers, more about how you move, think, and show up. This conversation goes beyond workouts. It’s about what actually makes progress stick. 🔥 “Real strength shows up outside perfect con...

200 EPISODES. 🤯 Only ~3% of podcasts ever make it this far… and somehow, here we are. What started as “just hit record and talk about this week” turned into 200 conversations, countless lessons, and a platform that’s grown beyond anything we expected. From breaking down health, fitness, and nutrition…To diving into mindset, relationships, and performance…To sitting down with incredible guests lik...