The IVF Journey with Dr Michael Chapman

In this episode, Prof Chapman explains how embryologists grade a day five blastocyst and what those numbers and letters actually mean for your chances of pregnancy. He walks through the development scale from one to five, the A to D grades for the inner cell mass that becomes the baby and the outer layer that forms the placenta, and why the gap between an AA and a BB is only a few percentage point...

In this episode, Prof Chapman answers a listener’s question about trying for a baby with endometriosis. He explains that while the condition is being diagnosed more often, most women with endometriosis still go on to conceive, though the stage of the disease matters. He walks through the assessments worth considering, from a detailed specialist ultrasound and laparoscopy to checking that the...

In this episode, Prof Chapman takes you inside the IVF laboratory to follow the journey from egg to embryo. He explains why stimulation aims for multiple eggs, how scientists recognise a mature egg, and why egg quality can decline with age. He also covers the two ways eggs are fertilised, conventional IVF and ICSI, what to expect from that next-morning phone call, and how time-lapse incubators hav...

In this episode, Prof Chapman answers a listener question from Mary, who asks whether stopping Ozempic six weeks before an IVF cycle could affect the outcome. He explains that while drug companies remain cautious for now, no abnormalities have been detected in the many pregnancies occurring in women using these medications. In fact, because obesity can impair fertility, the weight loss these drugs...

In this episode, Prof Chapman unpacks the science behind immune add-ons in IVF, explaining why an embryo behaves almost like a transplant and how a woman’s body has to tolerate a pregnancy that is half foreign. Responding to a listener’s question about steroids, NK cells and CRP, he separates the one immunological condition backed by real evidence, antiphospholipid syndrome, from the m...

In this episode, Prof Chapman unpacks the science behind IVF stimulation protocols and why they sit at the heart of a fertility specialist’s skill. He explains how the short antagonist cycle became the standard for around 95% of Australian cycles, why it has largely replaced the older long protocol, and how it lowers the risk of ovarian hyperstimulation. He also breaks down how your doctor d...

In this episode, Prof Chapman unpacks one of the more contested questions in male fertility, whether to surgically repair a varicocele or move directly to IVF. He explains why these varicose veins around the testicle may quietly warm it beyond its optimal temperature and dampen sperm production, and why the evidence for fixing them is far more borderline than many assume. Drawing on decades of res...

In this episode, Prof Chapman answers two listener questions that cut to the heart of some common fertility confusion. First, does the pill cause PCOS? The short answer is no, but the fuller story is more interesting, including why scientists may soon be renaming the condition PMOS, and how coming off the pill can unmask irregular periods that were there all along. Prof Chapman then turns to a lis...

In this episode, Prof Chapman unpacks extended carrier screening, the test that helps prevent some of the rarest and most serious childhood diseases before a baby is even conceived. He explains how we all carry genetic mutations without knowing it, in fact 98% of us do, and why they only become a problem when both partners happen to share the same one. Prof Chapman walks through the three most com...

In this episode, Prof Chapman tackles a question many patients wonder about but rarely ask: should depression and anxiety screening be standard before starting IVF? His answer is a firm no, and he explains why, drawing on the history of mandatory counselling in Victoria that was eventually abandoned because 95% of patients simply didn’t need it. But that doesn’t mean the emotional side...

In this episode, Prof Chapman unpacks the reality behind delayed parenthood, a trend driven by both partners as often as by women alone. He explains how the odds of conceiving within a year fall from around 90% at 35 to roughly 60% by 40, and why declining egg quality and numbers sit at the heart of that shift. He walks through egg freezing as a hedge against the ticking clock, noting that 30 to 3...

In this episode, Prof Chapman cuts through the tests and treatments marketed to women after recurrent miscarriage and asks a simple question: where’s the evidence? He unpacks the $1,500 endometrial receptivity test shown to have no benefit, the pivot to microbiome testing, and immune treatments sold without solid proof — while separating what’s genuinely useful from what he calls &#822...

In this episode, Prof Chapman takes a hard look at the growing menu of tests and treatments marketed to women after recurrent miscarriage — and asks a simple question: where’s the evidence? He unpacks the $1,500 endometrial receptivity test that took eight years and a gold-standard trial to show no benefit, the same company’s pivot to uterine microbiome testing, and the murky world of...

In this episode, Prof Chapman tackles one of the most heartbreaking questions in fertility, why miscarriages keep happening. Responding to a listener who has faced four losses across natural and IVF conceptions, he walks through the biggest culprit, genetic abnormalities in the embryo, and explains why age and egg quality sit at the centre of it all. He unpacks the other hidden causes worth invest...

In this episode, Prof Chapman unpacks what specialists actually mean when they talk about egg quality. He explains that quality comes down to an egg’s competency to fertilise and produce an embryo with the right number of chromosomes, and why that process becomes less reliable as women age. He describes the tiny energy-producing structures called mitochondria, the batteries inside every egg,...

In this episode, Prof Chapman explains one of fertility’s biggest puzzles: why a woman’s biological clock runs down so much faster than the rest of her body. Drawing on decades of experience and more than three and a half thousand babies, he walks through the remarkable journey of your eggs, from the millions laid down before you were even born, to the half a million you had at birth,...

In this episode, Prof Chapman and fertility nurse Natalie tackle one of the most-asked questions on the YouTube channel: the recent renaming of PCOS to PMOS. Prof Chapman explains how the change came out of a roomful of specialists, each with their own stake in the name, and why he sees it as a positive move, not least because so many patients hear “cysts on the ovary” and immediately...

In this episode, Prof Chapman is joined by fertility nurse Natalie to answer one of the most common questions from listeners: what should you do when you’re in your 40s and cycle after cycle isn’t working? Natalie explains why going back to basics matters — reviewing your initial workup, checking whether tests like AMH and antral follicle counts need repeating, and looking at inflammat...

In this episode, Prof Chapman answers a listener question about the future of IVF, covering what innovations are genuinely exciting and whether treatment will become more accessible and affordable. He reflects on how success rates have climbed from 10% to around 40% per embryo transfer over three decades, and gives his honest take on the current “flavours of the month”: AI in embryo se...

In this episode, Prof Chapman sits down with fertility nurse Natalie to talk about the moments IVF patients often face alone — the late-night bleeding scare, the anxious wait after a positive test, the questions that come up between appointments. They discuss why a positive pregnancy test isn’t the finish line, the reassurance of regular early-pregnancy monitoring through to 10 weeks, and ho...

In this episode, Prof Chapman is joined by a fertility nurse to unpack what should happen after a failed IVF cycle — and why so many patients are left without answers. They explore the emotional fallout of a negative pregnancy test, the delays patients face in getting support from busy clinics, and the value of having someone who can genuinely listen between appointments. Prof Chapman also shares...

In this episode, Prof Chapman is joined by a fertility support nurse to explore the gaps in patient care during IVF treatment. They discuss the most common concerns women face — from needle phobia and administering that first injection, to post-egg-collection bleeding and knowing when symptoms warrant escalation. Prof Chapman offers a frank comparison of Australia’s premium versus low-cost I...

Prof. Chapman introduces Natalie from Australia IVF Concierge, highlighting the emotional and practical support gap patients face at home during fertility treatment. Focus: the psychological burden of IVF (60% first-cycle failure rate), medication management, injection anxiety, and waiting uncertainty. Natalie explains how nurse-led home visits provide reassurance, education, and holistic support...

In this episode, Prof Chapman explains ovarian tissue cryopreservation, including who it is genuinely suitable for, why it remains largely an experimental fertility preservation technique, and its role for women facing urgent cancer treatment. He also answers a detailed question from a patient who has received a strong positive beta hCG result following embryo transfer. Prof Chapman discusses whet...

In this episode, Prof Chapman explains how he approaches patients who have already spent tens of thousands of dollars on unsuccessful IVF treatment and are seeking a second opinion. He discusses the importance of reviewing previous cycles in detail, identifying anything that may have been missed, and tailoring a new treatment strategy to improve outcomes. Prof Chapman also highlights the often-ove...