Generation Health

We're celebrating our 100th episode by answering YOUR questions! Joey DiMatteo (PharmD CCN) and Dante DiMatteo (PharmD) answer questions about a wide variety of concerns like supplement interactions, vitamin dosage changes, medication timing, petroleum based supplements and more. They bring their years of experience as practicing pharmacists to bear with honest, direct answers to common family med...

Is AI ready to take you from fat to fit? That's what researchers hoped to answer in a recent clinical study. Looking at three different models of ChatGPT, professional trainers analyzed 12 week training programs the AI provided based on hypothetical users. Dante DiMatteo, a human personal trainer, digs through the data to show what worked and where having an experienced human to guide is a good id...

There's been a major paradigm shift in how and why to use a probiotic. We explain why the old view of probiotics—tools to "recolonize" the gut with new bacteria—is outdated. Instead, the latest science shows that we use probiotics to gain specific, temporary physiological responses. Using data from 70+ randomized controlled trials, we look at why strain specificity matters far more than just a mas...

If you have been hesitant to start a statin or are currently struggling with muscle aches and fatigue, the culprit might not be the medication. In this episode, we break down a massive 2026 clinical review of 23 randomized trials involving over 120,000 patients. The data reveals a staggering reality: the "nocebo effect" —the phenomenon where negative expectations cause real physical symptoms— expl...

In Episode 096, Joey DiMatteo (PharmD, CCN) digs through two decades of neuroplasticity research to uncover how our internal "mental scripts"—the beliefs we hold about ourselves and our world—are physically wired into our brain architecture. While these patterns are difficult to change as adults, the science reveals a profound window of opportunity in early childhood. We explore how a parent's ton...

Ultra-Processed Foods (UPFs) are currently the primary target of nutritional science, linked by various studies to nearly every major negative health outcome. This wave of research recently led California to become the first state to ban UPFs from school lunches. However, a significant problem remains: there is no universal, clinical definition for what actually constitutes an "ultra-processed" fo...

Tramadol, a drug with more than 16 million U.S. prescriptions last year, is often viewed as the "safer opioid." However, new evidence suggests that perception is not just flawed, but dangerous. Pharmacist, Dante DiMatteo (PharmD), looks at the risks, including cardiac events and seizures, why it's still used, and what non-opioid pain solutions actually help. What's in the Bottle? New bone health p...

Are your antidepressants leaving you feeling physically drained? In this episode, Joey DiMatteo (PharmD) leads an evidence-based discussion on how SSRIs often cause hidden nutrient deficiencies that can hinder your mental health progress and reduce the effectiveness of the antidepressants. We break down the research and science behind drug-induced nutrient depletion, the specific vitamins you are...

In this episode, we are diving into a topic that—quite literally—gets people's blood pumping! We are looking at the brand new, 2025 American Heart Association and American College of Cardiology Hypertension Guidelines (AKA The PREVENT Standard), and to help us decode this massive document, we've got Dante DiMatteo (PharmD) in the hot seat. The medical community is calling this a "watershed moment....

Lithium appears to contribute to cognitive preservation during aging and a new study looks at what happens to the brain when lithium is deficient, possibly leading to Alzheimer's disease. Better still, it looks like increasing the brain's lithium levels may actually reverse the effects. Lithium orotate is getting a glow-up and we're excited for it! Also, the "magic pill" may finally be real. Wegov...

At the top of the year, U.S. Department of Health and Human Services Secretary Robert F. Kennedy, Jr. and U.S. Department of Agriculture Secretary Brooke Rollins released the Dietary Guidelines for Americans, 2025–2030, the most significant reset of federal nutrition policy in decades. Emphasizing "real food," the food pyramid we grew up with has essentially been turned upside down. Dante DiMatteo...

VO2 Max is having a moment. It seems every fitness influencer and longevity specialist has decided to focus on it as the key metric for determining your health. Is it important? Yes. But making that the key indicator of fitness is a trap.  Then, Dante fields a listener question: What do you do when red wine turns your face, well...bright red. How can you enjoy a glass while avoiding that awful fac...

What effect does your personality have on how you feel about exercise? Do traits like extroversion or openness impact what works best for you?  A new study suggests it could be the key factor in why some workouts work for some people and not others!  Dante DiMatteo (PharmD) unpacks all the details of the study, and offers suggestions from the research of how we can use our personality to actually...

Testosterone isn't just for men! We look at the effects testosterone has on everything from thyroid function, sexual dysfunction, and basic joy in life. We cover proper testing as well as the therapies, lifestyle changes, and supplements that can help boost low levels in women. Next, Dante examines the popular paleo diet and research that looks at the effects evolution, ecology, and economy has on...

A 2012 study (INCA) that only just came across our desk has huge implications for folks with Attention-Deficit Hyperactivity Disorder (ADHD), particularly kids! Joey DiMatteo (PharmD, CCN) examines how an elimination diet improves ADHD in children. How much can food choice really affect behavior and can restricting certain foods help manage ADHD symptoms? The study was on children, but the implica...

At last, the FDA has decided to remove the black box warning from topical hormone replacement therapies (HRTs) for menopause after years of pushback from women, and a comprehensive scientific review. We look at the original research that lead to the warnings and present evidence for their removal. Women were suffering unnecessarily because good research was mis-applied, and it took two decades for...

Two working pharmacists answering your questions! How can you safely switch asthma medications for kids? What supplements help with recovery from shingles? How much protein do kids actually need? Does Wegovy cause blindness?  And that's not even the full list!  If you've got a question, we'd love to hear it! Just drop it in the comments or send us an email (questions@askjoedimatteo.com)! ALL PRODU...

New research suggests that melatonin may be closely linked to the severity of ADHD symptoms in children. Genetic variations affecting melatonin production could contribute to ADHD symptoms, particularly through disrupted sleep patterns, suggesting the potential benefits of healthy sleep routines in managing ADHD symptoms. Plus, "What's In The Bottle?" Advanced Pre-Workout Sour Surge! Formulated wi...

When a listener question about calcium & vitamin D creates a great starting point for a dive into the way multiple nutrients work together to improve bone health. The FDA recently announced a plan to take action against natural, animal-derived thyroid medications. Why is the FDA suddenly taking action against a medication so old it predates the FDA itself? What are the advantages for the 1.5 milli...

The "Presidential Fitness Test" has a long history. Started in the 60's, radically changed under President Obama, and now returning under President Trump, it serves as an excellent example of good intentions with not-so-great results. Will its return help solve the childhood obesity crisis? We dig into the good, the bad, the awkward, and everything in between. Plus, "What's in the Bottle," you ask...

Dante answers a listener question about how prebiotics, fiber supplements, and whether they interact with Lipitor. There's a lot of hype around prebiotics, but is any of it justified? Plus, a new study illustrates the opposing roles dopamine and serotonin play in shaping our decisions and learning processes. Joey discusses how  understanding these key brain chemicals can lead to faster learning an...

President Trump, now in his second term, has signed two executive orders he believes will lower prescription drug prices. He's pressuring "big pharma", trying to cut out PBM's (Pharmacy Benefits Managers), and restricting how much Medicare and Medicaid will pay. Is it enough? Are these even the right targets? What will all of this mean when picking up a prescription? We dig into the details and ta...

When two different studies came out looking at the association of type 2 diabetes and Alzheimer's risk, we knew we had to dig in! What exactly are the risks? What is the connection? Do any medicines help negate those risks? Joey has the details. What's in the Bottle? Creatine Essentials! Creatine has been getting a ton of press lately, and for good reason! While the body makes a limited amount of...

Josiah unintentionally set us up for a conversation about a fantastic new study: Do you REALLY need a coach or trainer if you want to start exercising? Will they actually make a difference? That was the question a new study asked and the answer was a resounding "YES!" In "What's in the Bottle?," Joey explains exactly how the body responds to stress, and particularly chronic stress. From there, he...

How is your brain affected by what you (over) eat? We examine a study which shows that even a brief period of overeating ultra-processed, high-calorie snacks can lead to lasting disruption in the brains insulin response & liver fat accumulation. Behind the Counter, shocking almost no one, science proves that weed makes you dumber. "What's in the Bottle?," you ask? Iron Advanced Essentials! Iron su...