Base by Base - Music

This release contains only the music track from Base by Base Episode 416. Song title: Borrowed Light, New Wings Original Base by Base episode: 416: HGT-chimeras: fusion across the tree of life Article metadata: Article title: Evolutionary innovation through fusion of sequences from across the tree of life Journal: PNAS DOI: 10.1073/pnas.2602557123 Reference: Kapoor RR, Rona I, Extavour CG, et al....

This release contains only the music track from Base by Base Episode 415. Song title: Pocket in the Dark Original Base by Base episode: 415: ERG Unlocked: Targeting the PNT Domain with PBITE-1 Article metadata: Article title: A ligandable PNT domain establishes ERG as a directly targetable oncogenic driver in prostate cancer Journal: PNAS DOI: https://doi.org/10.1073/pnas.2537437123 Reference: htt...

This release contains only the music track from Base by Base Episode 414. Song title: Thirty-Five Generations of Light Original Base by Base episode: 414: Durability of Cas9 Gene Drives in Anopheles: A 2‑Year Cage Study Article metadata: Article title: Long-term stability and performance of Cas9/guide RNA-based gene drives in anopheline mosquitoes Journal: PNAS (2026) DOI: 10.1073/pnas.2605739123...

This release contains only the music track from Base by Base Episode 413. Song title: Three Places to Hold the Fire Original Base by Base episode: 413: Rpc34 WH2 dynamics in RNA polymerase III Article metadata: Article title: Dynamic positioning of Rpc34 winged helix in RNA polymerase III elongation complex for its stability with implications for reinitiation Journal: PNAS DOI: 10.1073/pnas.260177...

This release contains only the music track from Base by Base Episode 412. Song title: Consensus in the Dark Original Base by Base episode: 412: Fault Lines in Forensic Proficiency Testing Article metadata: Article title: Assessing the foundations of forensic identification evidence: A critical examination of proficiency test design and results Journal: PNAS DOI: 10.1073/pnas.2528192123 Reference:...

This release contains only the music track from Base by Base Episode 412. Song title: Consensus in the Dark Original Base by Base episode: 412: Fault Lines in Forensic Proficiency Testing Article metadata: Article title: Assessing the foundations of forensic identification evidence: A critical examination of proficiency test design and results Journal: PNAS DOI: 10.1073/pnas.2528192123 Reference:...

This release contains only the music track from Base by Base Episode 411. Song title: Spots in the Dark Original Base by Base episode: 411: EKV cells and the Human Prion Assay: a scalable platform for sCJD infectivity Article metadata: Article title: A scalable, dividing cell model for the robust propagation and quantification of human sporadic Creutzfeldt–Jakob disease prions Journal: PNAS DOI: 1...

This release contains only the music track from Base by Base Episode 410. Song title: More Than a Number Original Base by Base episode: 410: Nucleotide diversity is a poor predictor of short-term adaptive potential Article metadata: Article title: Nucleotide diversity is a poor predictor of short-term adaptive potential Journal: PNAS DOI: 10.1073/pnas.2536181123 Reference: Abson KL, Zijmers L, Mit...

This release contains only the music track from Base by Base Episode 409. Song title: Modular Fire in the Sugarlight Original Base by Base episode: 409: A systems-level atlas of carbon-response transcriptional states in Escherichia coli Article metadata: Article title: A systems-level atlas of carbon-response transcriptional states in Escherichia coli Journal: PNAS DOI: 10.1073/pnas.2531884123 Ref...

This release contains only the music track from Base by Base Episode 408. Song title: Fusion Switch (Tau Let Go) Original Base by Base episode: 408: Tau, mitochondria, and the fusion switch Article metadata: Article title: Tau protein as a regulator of mitochondrial function and dynamics Journal: Proceedings of the National Academy of Sciences (PNAS) DOI: 10.1073/pnas.2521642123 Reference: Tsakiri...

This release contains only the music track from Base by Base Episode 407. Song title: Lock the Metals Away Original Base by Base episode: 407: SLC11A2 withholds metals from Salmonella in the gut epithelium Article metadata: Article title: SLC11A2 withholds divalent metals from Salmonella in the gut epithelium Journal: Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.2532675123 Ref...

This release contains only the music track from Base by Base Episode 406. Song title: Cold Side of the Gut Original Base by Base episode: 406: Temperature & Age Shape Gut Susceptibility to HCoV-229E Article metadata: Article title: Temperature and developmental stage govern intestinal susceptibility to human coronavirus 229E Journal: Proceedings of the National Academy of Sciences (PNAS) DOI:...

This release contains only the music track from Base by Base Episode 405. Song title: Symmetry in the Sparks Original Base by Base episode: 405: PRDM9 and the Hotspot Trade-off Article metadata: Article title: On the origin of PRDM9-guided recombination hotspots Journal: Proceedings of the National Academy of Sciences (PNAS) DOI: 10.1073/pnas.2535682123 Reference: Úbeda F, Bürger R, Fyon F. On the...

This release contains only the music track from Base by Base Episode 404. Song title: DNA on the Outside Original Base by Base episode: 404: RUNA Reveals Surface DNA on Exosomes Article metadata: Article title: A nucleic acid labeling chemistry reveals surface DNA on exosomes Journal: Proceedings of the National Academy of Sciences DOI: 10.1073/pnas.2532281123 Reference: Bošković F, Dutta Gupta P,...

This release contains only the music track from Base by Base Episode 404. Song title: Scars That Tell the Truth Original Base by Base episode: 404: HRD-GIS refines BRCA1/2 variant classification in ovarian cancer Article metadata: Article title: Homologous recombination deficiency-driven genomic instability in ovarian cancer as an indicator of BRCA1 and BRCA2 variant pathogenicity Journal: The Ame...

This release contains only the music track from Base by Base Episode 403. Song title: Scars That Tell the Truth Original Base by Base episode: 403: HRD-GIS Evidence for BRCA1/2 Variant Classification Article metadata: Article title: Homologous recombination deficiency-driven genomic instability in ovarian cancer as an indicator of BRCA1 and BRCA2 variant pathogenicity Journal: The American Journal...

This release contains only the music track from Base by Base Episode 402. Song title: Outliers in the Light Original Base by Base episode: 402: When Polygenic Scores Miss: Rare Variants in Misaligned Individuals Article metadata: Article title: Individuals who deviate from polygenic expectation are enriched for damaging variants in genes linked to rare disease Journal: The American Journal of Huma...

This release contains only the music track from Base by Base Episode 401. Song title: Two Ends of the Same Thread Original Base by Base episode: 401: LDB1 variants split neurodevelopmental outcomes by location and mechanism Article metadata: Article title: De novo variants in LDB1 are linked to distinct neurodevelopmental phenotypes determined by variant location and differing pathomechanisms Jour...

This release contains only the music track from Base by Base Episode 401. Song title: Two Ends of the Same Thread Original Base by Base episode: 401: LDB1 variants split neurodevelopmental outcomes by location and mechanism Article metadata: Article title: De novo variants in LDB1 are linked to distinct neurodevelopmental phenotypes determined by variant location and differing pathomechanisms Jour...

This release contains only the music track from Base by Base Episode 400. Song title: Tenfold Between Us Original Base by Base episode: 400: Complete chromosome 21 centromere sequencing and Down syndrome Article metadata: Article title: Complete chromosome 21 centromere sequencing of families with Down syndrome Journal: The American Journal of Human Genetics DOI: 10.1016/j.ajhg.2026.05.010 Referen...

This release contains only the music track from Base by Base Episode 399. Song title: Spiral in the Signal Original Base by Base episode: 399: Ménière disease: inner ear development and retinoic acid pathways Article metadata: Article title: Genome-wide analysis implicates inner ear development in Ménière disease Journal: The American Journal of Human Genetics DOI: 10.1016/j.ajhg.2026.05.011 Refer...

This release contains only the music track from Base by Base Episode 398. Song title: Not Just the Slope Original Base by Base episode: 398: Modeling JAK2V617F Clonal Expansion in the General Population Article metadata: Article title: Mathematical modeling of JAK2V617F clonal expansion in a general population cohort Journal: Proceedings of the National Academy of Sciences (PNAS) DOI: 10.1073/pnas...

This release contains only the music track from Base by Base Episode 397. Song title: Hazy Tree, True Time Original Base by Base episode: 397: SciPhy: Bayesian phylogenetics for sequential genetic lineage tracing Article metadata: Article title: SciPhy: A Bayesian phylogenetic framework using sequential genetic lineage tracing data Journal: Nature Communications DOI: 10.1038/s41467-026-73377-6 Ref...

This release contains only the music track from Base by Base Episode 396. Song title: Helix in the Dark Original Base by Base episode: 396: Physical homology recognition between DNA duplexes Article metadata: Article title: Direct evidence and quantification of homologous recognition between DNA duplexes Journal: Proceedings of the National Academy of Sciences (PNAS) DOI: 10.1073/pnas.2530949123 Re...

This release contains only the music track from Base by Base Episode 395. Song title: Context Writes the Curve Original Base by Base episode: 395: Extended sequence context shapes mutational bias in Escherichia coli Article metadata: Article title: Extended sequence context shapes mutational bias in Escherichia coli Journal: PNAS DOI: 10.1073/pnas.2601345123 Reference: Green R., Jago M.J., Knight...