Sensible Medicine

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Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy * The Hubris of Screening for Disease — Again Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment * Why Blood Tests Are a Poor Screening Tool for Alzheimer’s This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus epi...

Cancer-Related Mortality Among US Pilots and Flight Attendants Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Our free series is almost over This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

New lectures coming soon (after part 9) This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

A royal mistake This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

we are making all the old episodes available for free, and then on to the new ones -v This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

New episodes coming soon. First 9 parts free now. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Coronary-Artery Revascularization before Elective Major Vascular Surgery Discontinuation of statins for primary prevention of atherosclerotic cardiovascular disease in adults aged 75 years or older (SAGA/SITE): a multicentre, open-label, pragmatic, non-inferiority randomised trial This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit...

I notice that someone was angry that we are re-posting old episodes BEFORE we post the new ones. Just a reminder, we said we would do this! We will make the old ones available for free, and then post the new ones. Bear with us. In the meantime, enjoy. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

And here is lecture 3 of How Not to Be Fooled series 19 parts coming! 9 for free, and 10 for subscribers. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial Impact of cognitive training on claims-based diagnosed dementia over 20 years: evidence from the ACTIVE study This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men A Randomized Clinical Trial * Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment Cost-Effectiveness of Fecal Immunochemical Testing Alone vs Co-Testing With Helicobacter pylori Stool Antigen This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes...

Polypill for heart failure with reduced ejection fraction: the POLY-HF randomized trial John Mandrola: I am torn on the PolyPill concept This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia * Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis The Impact of Midodrine on Guideline-Directed Medical Therapy in Patients Admitted With Systolic Heart Failure This is a public episode. If you'd like to discuss this with other subscribers or get a...

TR is an 88-year-old man who is disabled and in chronic pain from spinal stenosis and knee osteoarthritis. He has multiple other medical issues, including coronary artery disease and COPD. He has been through years of treatment for his knees and back, including physical therapy, multiple joint injections, and an in-office procedure for spinal stenosis. He has been on multiple regimens of oral pain...

Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults * Prespecified Falsification End Points: Can They Validate True Observational Associations? * Ultrasonography versus Computed Tomography for Suspected Nephrolithiasis GLP-1 receptor agonist use and cancer risk in obese nondiabetic adults * Risk for Cancer With Glucagon-Like Peptide-1 Receptor Agonists and Dual Agonists: A Systema...

Reduced Melanoma After Regular Sunscreen Use: Randomized Trial Follow-Up GLP-1 Receptor Agonists or SGLT2 Inhibitors and Nonarteritic Anterior Ischemic Optic Neuropathy * Previously discussed on Fornight XXII: Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study This is a public episode. If you'd like to discuss this wit...

Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients * Real-World Effectiveness of Nirmatrelvir–Ritonavir Against Severe Outcomes of COVID-19 in Taiwan: A Nationwide Population-Based Cohort Study Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage * Effect of Combination Therapy on Adherence Among US Patients Initiating Therapy for Hypertension: a...

RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism * Endovascular management of intermediate-risk pulmonary embolism: evidence, outstanding questions, drivers of utilization, and the horizon This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus...

Dengue Suppression by Male Wolbachia-Infected Mosquitoes * World Mosquito Program Antibiotic Therapy for Uncomplicated Acute Appendicitis This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

* Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study * Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction * Andrew’s previous SM post on the subject: How a Meta-Analysis can Mislead—The Story of Complete vs Culprit-only PCI in STEMI And, a bunch of the other studies we discussed. * Complete Revascular...

Sodium Correction Rates and Associated Outcomes Among Patients With Severe Hyponatremia: A Retrospective Cohort Study * A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients Effect of Neuromuscular Warm-up on Injuries in Female Soccer and Basketball Athletes in Urban Public High Schools * Why Are So Many Teen Girls Still Tearing Their A.C.L.s? * Injury prevention programs...