Sensible Medicine

Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia * Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis The Impact of Midodrine on Guideline-Directed Medical Therapy in Patients Admitted With Systolic Heart Failure This is a public episode. If you'd like to discuss this with other subscribers or get a...

TR is an 88-year-old man who is disabled and in chronic pain from spinal stenosis and knee osteoarthritis. He has multiple other medical issues, including coronary artery disease and COPD. He has been through years of treatment for his knees and back, including physical therapy, multiple joint injections, and an in-office procedure for spinal stenosis. He has been on multiple regimens of oral pain...

Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults * Prespecified Falsification End Points: Can They Validate True Observational Associations? * Ultrasonography versus Computed Tomography for Suspected Nephrolithiasis GLP-1 receptor agonist use and cancer risk in obese nondiabetic adults * Risk for Cancer With Glucagon-Like Peptide-1 Receptor Agonists and Dual Agonists: A Systema...

Reduced Melanoma After Regular Sunscreen Use: Randomized Trial Follow-Up GLP-1 Receptor Agonists or SGLT2 Inhibitors and Nonarteritic Anterior Ischemic Optic Neuropathy * Previously discussed on Fornight XXII: Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study This is a public episode. If you'd like to discuss this wit...

Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients * Real-World Effectiveness of Nirmatrelvir–Ritonavir Against Severe Outcomes of COVID-19 in Taiwan: A Nationwide Population-Based Cohort Study Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage * Effect of Combination Therapy on Adherence Among US Patients Initiating Therapy for Hypertension: a...

RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism * Endovascular management of intermediate-risk pulmonary embolism: evidence, outstanding questions, drivers of utilization, and the horizon This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus...

Dengue Suppression by Male Wolbachia-Infected Mosquitoes * World Mosquito Program Antibiotic Therapy for Uncomplicated Acute Appendicitis This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

* Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study * Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction * Andrew’s previous SM post on the subject: How a Meta-Analysis can Mislead—The Story of Complete vs Culprit-only PCI in STEMI And, a bunch of the other studies we discussed. * Complete Revascular...

Sodium Correction Rates and Associated Outcomes Among Patients With Severe Hyponatremia: A Retrospective Cohort Study * A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients Effect of Neuromuscular Warm-up on Injuries in Female Soccer and Basketball Athletes in Urban Public High Schools * Why Are So Many Teen Girls Still Tearing Their A.C.L.s? * Injury prevention programs...

Most conversations about “AI in Medicine” bore me. I think this is because either we lack the imagination to consider how AI will change medicine in the next decade, or we are not being specific enough about how small parts of medicine could be productively affected. Dr. Shantanu Nundy, MD, MBA, is a practicing physician whom I like to think of as a serial innovator. He is currently an advisor on...

High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults * High-Dose Influenza Vaccine to Reduce Hospitalizations * Efficacy of high-dose versus standard-dose influenza vaccine in older adults Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial This is a public episode. If you'd like to discuss this with other subscribers or get access t...

Today on the podcast, I am joined by Dr. Jennifer Rusiecki. Dr. Rusiecki is an Associate Professor of Medicine at the University of Chicago. She is the Director of Women’s Health and Gender-Based Care in the internal medicine residency program and the assistant clinic director overseeing gender-based care. Dr. Rusiecki and I discussed the article appraised in the other post today, and also discuss...

A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction * Should Evidence Come with an Expiration Date? This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus...

No video this week — we had a bit of a computer meltdown — but two interesting articles. As always, thanks for listening. If you have articles you would like us to cover, please send us a suggestion at sensiblemedicine2022@gmail.com. This Substack is reader-supported. If you appreciate our work, consider becoming a free or paid subscriber. This is a public episode. If you'd like to discuss this wi...

In a lifetime of possible memories, only some are accessible. There are a few comments — made by mentors, co-residents, and patients — that have lingered and shaped my medical practice. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe

I was shocked at the comments on this post . Many people, some of them I know to be smart, thought I was nuts for suggesting two middle-aged women who had isolated high LDL-C needn’t take meds because their calculated 10-year risk was less than 3% What shocked me is that our guidelines suggest treatment with statins when 10-year risk is ≥ 7.5%. You may not know this but clinicians are supposed to...

Medical Management and Revascularization for Asymptomatic Carotid Stenosis Vagus nerve-mediated neuroimmune modulation for rheumatoid arthritis: a pivotal randomized controlled trial We spent quite a bit of time talking about blinding. This is the table on the adequacy of blinding from the supplement. It does seem like blinding was less than perfect. This is a public episode. If you'd like to disc...

We try to answer the remainder of your AUA questions. We will be back in the new year with more article discussions! Here are a few of the things we referenced. GDMT Bugs Me: A bit of a rant against the standard of care A Plan to Refocus Primary Care Sacrificing patient care for prevention: distortion of the role of general practice The Great Colonoscopy Debate Arthroscopic Partial Meniscectomy ve...

We cover questions from Amy J, Benjamin Hourani, Diana Stiles Friou, Chris Costas, Errol Laurie, Jim Healthy, Elizabeth Fama, Never Dull, Rod Rodriguez, Ellison Burns, David Araujo, and George. We have more to come! One nice reference I found while looking into some of the topics: DMSO Is Not a Cure-All. But the FDA’s Panic Over It Birthed a Myth This is a public episode. If you'd like to discuss...

Vascular and inflammatory diseases after COVID-19 infection and vaccination in children and young people in England: a retrospective, population-based cohort study using linked electronic health records Comparison of an Initial Risk-Based Testing Strategy vs Usual Testing in Stable Symptomatic Patients With Suspected Coronary Artery Disease: The PRECISE Randomized Clinical Trial This is a public e...

European Study of Prostate Cancer Screening — 23-Year Follow-up Association Between Baseline Diastolic Blood Pressure and the Efficacy of Intensive vs Standard Blood Pressure–Lowering Therapy Further Reading * Effects of intensive blood-pressure control in type 2 diabetes mellitus * A Randomized Trial of Intensive versus Standard Blood-Pressure Control Sensible Medicine is 100% reader-supported. I...

Effects of Intensive Blood Pressure Control in Patients With Frailty: A Post Hoc Analysis From ESPRIT * Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial * Reduction of Antihypertensive Treatment in Nursing Home Residents Polysacc...

Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults * The Ideal Cholesterol Level ... Depends...And Cannot Be Determined From Observational Studies Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function: The US POINTER Randomized Clinical Trial * Can We Please Stop Asking if Crossword Puzzles Prevent De...

Two papers this week, with a bunch of articles that we referenced in the conversation. Also, the last Fortnight podcast was accidentally posted behind a paywall. It is now up and free to listen to. My apologies. Sensible Medicine is reader-supported. If you appreciate our work, consider becoming a free or paid subscriber. Folinic acid improves verbal communication in children with autism and langu...