Science TLDR

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery](https://doi.org/10.1038/s41587-026-03128-x) **Authors:** Nan Wang, Hugh Yeh, Ben Lai, Jason Perera, Kevin M. Jude, et al. **Journal:** Nature Biotechnology, 2026 **Why it matters:** Mapping how T...

**Paper:** [The political polarization of health outcomes in the USA](https://doi.org/10.1038/s41562-026-02474-9) **Authors:** Elizabeth Elder, Neil A. O'Brian **Journal:** Nature Human Behaviour, 2026 **Why it matters:** Political ideology has emerged as a measurable social determinant of health in the United States, with conservative Americans showing widening gaps in both clinical biomarkers an...

**Paper:** [Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager](https://doi.org/10.1016/j.omton.2026.201201) **Authors:** Moon Jung Choi, Eui Young So, Bedia Akosman, Young Eun Lee, et al. **Journal:** Molecular Therapy Oncology, 2026 **Why it matters:** Glioblastoma has resisted every modern immunotherapy d...

**Paper:** [Climate-driven depopulation and adaptation realities in America's coastal ground zero](https://doi.org/10.1038/s41893-026-01820-z) **Authors:** Torbjörn E. Törnqvist, Brianna Castro, Jesse M. Keenan, Jayur M. Mehta, Zhixiong Shen **Journal:** Nature Sustainability, 2026 **Why it matters:** The central U.S. Gulf Coast — identified by the IPCC as the single most exposed low-elevation coa...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Engineering of acidic pH-responsive anti-CD3 binding antibodies](https://doi.org/10.1080/19420862.2026.2658902) **Authors:** Grégory La Sala, Katharina B. Kroell, Mudita Pincha, Christian Gassner, et al. **Journal:** mAbs, 2026 **Why it matters:** Tumor-selective T-cell engagers could dramatically reduce...

**Paper:** [Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study](https://doi.org/10.1186/s12916-023-03180-3) **Authors:** Wei-Jie Chen, Chun-Xia Gan, Yang-Wei Cai, Yang-Yang Liu, et al. **Journal:** BMC Medicine, 2023 **Why it matters:** Even when catheter ablation successfully restores h...

**Paper:** [Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology](https://doi.org/10.1002/ctm2.336) **Authors:** Barış Genç, Mukesh Gautam, Öge Gözütok, Ina Dervishi, Santana Sanchez, et al. **Journal:** Clinical and Translational Medicine, 2021 **Why it matters:** NU-9 is the first compound shown to halt upp...

**Paper:** [A trophoblast glycoprotein specific 5T4-Vδ2 bispecific T cell engager recruits Vγ9Vδ2-T cells for tumor-selective cytotoxicity across solid malignancies](https://doi.org/10.1016/j.clim.2026.110707) **Authors:** Milon de Jong, Rok Žiberna, Myrthe Veth, Elisabetta Michielon, et al. **Journal:** Clinical Immunology, 2026 **Why it matters:** Solid tumors have largely resisted bispecific T...

https://doi.org/10.1038/s41551-025-01569-4

https://doi.org/10.1038/s42256-025-01113-8

https://doi.org/10.1101/2025.06.06.657162

https://doi.org/10.1038/s41586-025-09655-y

https://doi.org/10.1542/peds.2024-070516

https://doi.org/10.1080/19420862.2025.2570748

https://doi.org/10.1038/s41380-025-03237-0

https://doi.org/10.1021/acs.biochem.5c00274

DOI: 10.1080/17460441.2025.2522088

https://doi.org/10.1016/j.cell.2025.07.046

https://doi.org/10.1038/s41586-025-09370-8

arXiv:2507.22291v1

https://doi.org/10.1016/j.jbc.2025.110490

https://doi.org/10.1016/j.celrep.2025.115965

https://doi.org/10.1038/s41557-025-01874-0

https://doi.org/10.1038/s41592-025-02723-1

https://doi.org/10.1038/s41562-025-02267-6