Science TLDR

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Covalently PD‐L1 Anchoring Drives Bispecific Nanostructure Assembly for Spatial Control of T Cell Recruitment and Activation](https://doi.org/10.1002/anie.5894316) **Authors:** Fengzhen Zhang, Yuhan Dong, Kailu Liu, Hui Hu, et al. **Journal:** Angewandte Chemie International Edition, 2025 **Why it matter...

**Top Trending Friday** — our weekly pick of the top-trending paper on r/science this week. **Paper:** [People prefer to negotiate with women, even when outcomes are identical and gender is unknown](https://doi.org/10.1073/pnas.2523202123) **Authors:** Charlotte H. Townsend, Laura J. Kray, Solène Delecourt **Journal:** Proceedings of the National Academy of Sciences, 2026 **Why it matters:** Decad...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Combination therapy with a novel CD2-targeted costimulatory bispecific antibody overcomes limitations of CD3 T cell engager treatment for solid tumors](https://doi.org/10.1080/19420862.2026.2684378) **Authors:** Welbeck Danquah, Mélanie Pichery, Thomas Eden, Aurelien Boyance, et al. **Journal:** mAbs, 20...

**Top Trending Friday** — our weekly pick of the top-trending paper on r/science this week. **Paper:** [A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone](https://doi.org/10.1038/s41586-026-10546-z) **Authors:** Xiaotong Peng, Peng Zhou, Xikun Song, Giovanni Bianucci, et al. **Journal:** Nature, 2026 **Why it matters:** The discovery of a 1,200-kilometer accumulation of whale...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow](https://doi.org/10.1016/j.ymthe.2026.05.032) **Authors:** SangPhil Ahn, Tae-Sung Oh, Seonghyuk Suh, Joon-Young Jeon, et al. **Journal:** Molecular Therapy, 2026 **Why it matters:** A hybrid computational-experim...

**Top Trending Friday** — our weekly pick of the top-trending paper on r/science this week. **Paper:** [Work from Home and Disability Employment](https://doi.org/10.1257/aeri.20240538) **Authors:** Nicholas Bloom, Gordon B. Dahl, Dan-Olof Rooth **Journal:** American Economic Review: Insights, 2025 **Why it matters:** The post-pandemic rise in remote work appears to have accomplished more for disab...

**Paper:** [From free speech advocates to critics: The Trump administration's new rhetoric promotes support for censorship among Trump voters](https://doi.org/10.1073/pnas.2532084123) **Authors:** Matthew E. K. Hall, B. Tyler Leigh, Brittany C. Solomon **Journal:** Proceedings of the National Academy of Sciences, 2026 **Why it matters:** The study offers rare experimental evidence — using real, no...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial](https://doi.org/10.1038/s41591-026-04455-x) **Authors:** Martin Wermke, Sebastian Ochsenreither, Dirk Jaeger, Heiko Becker, et al. **Journal:** Nature Medicine, 2025 **Why it matters...

**Paper:** [Language Modeling Materializes a World Model of Protein Biology](https://biohub.ai/papers/esm_protein.pdf) **Authors:** Salvatore Candido, Alexander Rives, et al. **Journal:** White paper — Biohub / Evolutionary Scale **Why it matters:** Training a protein language model on billions of diverse metagenomic sequences appears to produce not just pattern matching but an internally organize...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Novel bispecific T-cell engagers overcoming acquired EGFR resistance](https://doi.org/10.1080/19420862.2026.2674236) **Authors:** Lennart Kühl, Ann-Kathrin Löffler, Oliver Seifert, Dennis Michler, et al. **Journal:** mAbs, 2026 **Why it matters:** Acquired resistance to EGFR-targeted antibody therapies r...

**Paper:** [The lived experience of rejection sensitivity in ADHD — A qualitative exploration](https://doi.org/10.1371/journal.pone.0314669) **Authors:** Annabel Rowney-Smith, Beth Sutton, Lisa Quadt, Jessica A. Eccles **Journal:** PLOS One, 2024 **Why it matters:** Emotional dysregulation — and rejection sensitivity in particular — affects the majority of adults with ADHD yet remains largely abse...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery](https://doi.org/10.1038/s41587-026-03128-x) **Authors:** Nan Wang, Hugh Yeh, Ben Lai, Jason Perera, Kevin M. Jude, et al. **Journal:** Nature Biotechnology, 2026 **Why it matters:** Mapping how T...

**Paper:** [The political polarization of health outcomes in the USA](https://doi.org/10.1038/s41562-026-02474-9) **Authors:** Elizabeth Elder, Neil A. O'Brian **Journal:** Nature Human Behaviour, 2026 **Why it matters:** Political ideology has emerged as a measurable social determinant of health in the United States, with conservative Americans showing widening gaps in both clinical biomarkers an...

**Paper:** [Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager](https://doi.org/10.1016/j.omton.2026.201201) **Authors:** Moon Jung Choi, Eui Young So, Bedia Akosman, Young Eun Lee, et al. **Journal:** Molecular Therapy Oncology, 2026 **Why it matters:** Glioblastoma has resisted every modern immunotherapy d...

**Paper:** [Climate-driven depopulation and adaptation realities in America's coastal ground zero](https://doi.org/10.1038/s41893-026-01820-z) **Authors:** Torbjörn E. Törnqvist, Brianna Castro, Jesse M. Keenan, Jayur M. Mehta, Zhixiong Shen **Journal:** Nature Sustainability, 2026 **Why it matters:** The central U.S. Gulf Coast — identified by the IPCC as the single most exposed low-elevation coa...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Engineering of acidic pH-responsive anti-CD3 binding antibodies](https://doi.org/10.1080/19420862.2026.2658902) **Authors:** Grégory La Sala, Katharina B. Kroell, Mudita Pincha, Christian Gassner, et al. **Journal:** mAbs, 2026 **Why it matters:** Tumor-selective T-cell engagers could dramatically reduce...

**Paper:** [Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study](https://doi.org/10.1186/s12916-023-03180-3) **Authors:** Wei-Jie Chen, Chun-Xia Gan, Yang-Wei Cai, Yang-Yang Liu, et al. **Journal:** BMC Medicine, 2023 **Why it matters:** Even when catheter ablation successfully restores h...

**Paper:** [Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology](https://doi.org/10.1002/ctm2.336) **Authors:** Barış Genç, Mukesh Gautam, Öge Gözütok, Ina Dervishi, Santana Sanchez, et al. **Journal:** Clinical and Translational Medicine, 2021 **Why it matters:** NU-9 is the first compound shown to halt upp...

**Paper:** [A trophoblast glycoprotein specific 5T4-Vδ2 bispecific T cell engager recruits Vγ9Vδ2-T cells for tumor-selective cytotoxicity across solid malignancies](https://doi.org/10.1016/j.clim.2026.110707) **Authors:** Milon de Jong, Rok Žiberna, Myrthe Veth, Elisabetta Michielon, et al. **Journal:** Clinical Immunology, 2026 **Why it matters:** Solid tumors have largely resisted bispecific T...

https://doi.org/10.1038/s41551-025-01569-4

https://doi.org/10.1038/s42256-025-01113-8

https://doi.org/10.1101/2025.06.06.657162

https://doi.org/10.1038/s41586-025-09655-y

https://doi.org/10.1542/peds.2024-070516

https://doi.org/10.1080/19420862.2025.2570748