Raymond Ruff
Science TLDR
Ten-minute paper summaries for scientists and experts. Two episodes a week: Mondays feature the top-scoring paper from a curated weekly digest of T cell engager, bispecific antibody, and protein engineering literature. Fridays cover the top trending paper on PubMed — any field, whatever's catching the research community's attention that week. Hosted by Raymond Ruff, a protein scientist working in translational immunotherapeutics. Audio is generated with NotebookLM; the host prompt aims for measured scientific skepticism rather than hype. Feedback and paper suggestions: sciencetldrpod@gmail.com
Besuch unbedingt die Website des Podcasts und unterstütze die Macher: raymondruff.github.io
Autor
Raymond Ruff
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Podcast-Website
Neueste Folge
18. Okt 2026
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Episode 66: The political polarization of health outcomes in the USA 15.05.2026 19:57
**Paper:** [The political polarization of health outcomes in the USA](https://doi.org/10.1038/s41562-026-02474-9) **Authors:** Elizabeth Elder, Neil A. O'Brian **Journal:** Nature Human Behaviour, 2026 **Why it matters:** Political ideology has emerged as a measurable social determinant of health in the United States, with conservative Americans showing widening gaps in both clinical biomarkers an...
Episode 65: Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager 11.05.2026 21:34
**Paper:** [Enable CAR T cell immunotherapy in glioblastoma by modifying its microenvironment via oncolytic adenovirus encoding bispecific T cell engager](https://doi.org/10.1016/j.omton.2026.201201) **Authors:** Moon Jung Choi, Eui Young So, Bedia Akosman, Young Eun Lee, et al. **Journal:** Molecular Therapy Oncology, 2026 **Why it matters:** Glioblastoma has resisted every modern immunotherapy d...
Episode 64: Climate-driven depopulation and adaptation realities in America’s coastal ground zero 08.05.2026 23:43
**Paper:** [Climate-driven depopulation and adaptation realities in America's coastal ground zero](https://doi.org/10.1038/s41893-026-01820-z) **Authors:** Torbjörn E. Törnqvist, Brianna Castro, Jesse M. Keenan, Jayur M. Mehta, Zhixiong Shen **Journal:** Nature Sustainability, 2026 **Why it matters:** The central U.S. Gulf Coast — identified by the IPCC as the single most exposed low-elevation coa...
Episode 63: Engineering of acidic pH-responsive anti-CD3 binding antibodies 04.05.2026 21:28
**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Engineering of acidic pH-responsive anti-CD3 binding antibodies](https://doi.org/10.1080/19420862.2026.2658902) **Authors:** Grégory La Sala, Katharina B. Kroell, Mudita Pincha, Christian Gassner, et al. **Journal:** mAbs, 2026 **Why it matters:** Tumor-selective T-cell engagers could dramatically reduce...
Episode 62: Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study 01.05.2026 23:16
**Paper:** [Impact of high-power short-duration atrial fibrillation ablation technique on the incidence of silent cerebral embolism: a prospective randomized controlled study](https://doi.org/10.1186/s12916-023-03180-3) **Authors:** Wei-Jie Chen, Chun-Xia Gan, Yang-Wei Cai, Yang-Yang Liu, et al. **Journal:** BMC Medicine, 2023 **Why it matters:** Even when catheter ablation successfully restores h...
Episode 61: Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology 24.04.2026 20:57
**Paper:** [Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP‐43 pathology](https://doi.org/10.1002/ctm2.336) **Authors:** Barış Genç, Mukesh Gautam, Öge Gözütok, Ina Dervishi, Santana Sanchez, et al. **Journal:** Clinical and Translational Medicine, 2021 **Why it matters:** NU-9 is the first compound shown to halt upp...
Episode 60: A trophoblast glycoprotein specific 5 T4-Vδ2 bispecific T cell engager recruits Vγ9Vδ2-T cells for tumor-selective cytotoxicity across solid malignancies 22.04.2026 22:39
**Paper:** [A trophoblast glycoprotein specific 5T4-Vδ2 bispecific T cell engager recruits Vγ9Vδ2-T cells for tumor-selective cytotoxicity across solid malignancies](https://doi.org/10.1016/j.clim.2026.110707) **Authors:** Milon de Jong, Rok Žiberna, Myrthe Veth, Elisabetta Michielon, et al. **Journal:** Clinical Immunology, 2026 **Why it matters:** Solid tumors have largely resisted bispecific T...
A trispecific antibody engaging T cells with tumour and myeloid cells augments antitumour immunity 24.12.2025 11:55
https://doi.org/10.1038/s41551-025-01569-4
Language models cannot reliably distinguish belief from knowledge and fact 07.11.2025 14:45
https://doi.org/10.1038/s42256-025-01113-8
Spatially organized inflammatory myeloid-CD8+ T cell aggregates linked to Merkel-cell Polyomavirus driven Reorganization of the Tumor Microenvironment 06.11.2025 19:20
https://doi.org/10.1101/2025.06.06.657162
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade 28.10.2025 16:37
https://doi.org/10.1038/s41586-025-09655-y
Guidelines for Early Food Introduction and Patterns of Food Allergy 22.10.2025 14:34
https://doi.org/10.1542/peds.2024-070516
Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design 16.10.2025 15:29
https://doi.org/10.1080/19420862.2025.2570748
A genetic common factor underlying self-reported math ability and highest math class taken 11.10.2025 16:07
https://doi.org/10.1038/s41380-025-03237-0
Profiling Hinge Plasticity in Intact Monoclonal Antibodies for Antigen Recognition 15.09.2025 13:57
https://doi.org/10.1021/acs.biochem.5c00274
The impact of CD3 affinity-attenuation on T cell engaging bispecific antibodies: is it really that simple? 12.09.2025 17:02
DOI: 10.1080/17460441.2025.2522088
Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy 29.08.2025 19:23
https://doi.org/10.1016/j.cell.2025.07.046
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy 26.08.2025 20:18
https://doi.org/10.1038/s41586-025-09370-8
AlphaEarth Foundations: An embedding field model for accurate and efficient global mapping from sparse label data 06.08.2025 18:47
arXiv:2507.22291v1
Single-Chain Fab Chain-Exchange (scFab-PACE) converts targeted prodrugs into functional T cell engagers on tumor cells 05.08.2025 16:30
https://doi.org/10.1016/j.jbc.2025.110490
Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement 04.08.2025 12:05
https://doi.org/10.1016/j.celrep.2025.115965
Navigating protein landscapes with a machine-learned transferable coarse-grained model 30.07.2025 15:34
https://doi.org/10.1038/s41557-025-01874-0
Sliding Window Interaction Grammar (SWING): a generalized interaction language model for peptide and protein interactions 30.07.2025 16:44
https://doi.org/10.1038/s41592-025-02723-1
Predicting human decisions with behavioural theories and machine learning 29.07.2025 18:03
https://doi.org/10.1038/s41562-025-02267-6
Tuning antibody stability and function by rational designs of framework mutations 27.07.2025 14:28
https://doi.org/10.1080/19420862.2025.2532117
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