Science TLDR

Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. "It's Like You're Trying to Defuse a Bomb": Fear, Responsibility, and Shame in Young Men's Sexual Lives Journal of Sex & Marital Therapy, 2026 DOI: 10.1080/0092623X.2026.2740624 Question: How do young heterosexual men, raised amid consent-focused sex education, emotionally experience sex? Answer: In 31 inte...

Monday Immune Engager — our weekly pick from the latest immune-engager digest. Validation and analysis of 12,000 AI-driven CAR-T designs in the Bits to Binders competition Molecular Systems Biology, 2026 DOI: 10.1038/s44320-026-00246-1 Question: Do AI-designed minibinders function as CAR-T antigen-recognition domains, not just as high-affinity binders in isolation? Answer: Across 12,000 designs fr...

Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Not with a Bang but a Whimper: Congressional Silence Amid an Historic Assault on the Power of the Purse PS: Political Science & Politics, 2025 DOI: 10.1017/S1049096525101704 Question: Why has Congress barely resisted President Trump's unilateral impoundments and tariffs, actions that assault its constitutio...

Monday Immune Engager — our weekly pick from the latest immune-engager digest. GPCR antagonism via rewiring of receptor trafficking and degradation Nature, 2026 DOI: 10.1038/s41586-026-11088-0 Question: Can bispecific antibodies that hijack transferrin receptor 1 trafficking degrade GPCRs that are hard to block with conventional antagonists? Answer: Yes in overexpression systems and one short-term...

Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Did Donald Trump Receive a Mandate for Sweeping Change in 2024? PS: Political Science & Politics, 2025 DOI: 10.1017/S1049096525101868 Question: Did Trump's 2024 victory and subsequent polling give him a genuine public mandate for the sweeping changes he and his team claimed? Answer: No, by the author's crit...

Monday Immune Engager — our weekly pick from the latest immune-engager digest. Specific targeting of MR1-antigen complexes using nanobodies Science Immunology, 2025 DOI: 10.1126/sciimmunol.aeb8726 Question: Can nanobodies be raised to selectively recognize MR1 only when it presents a spec

Monday Immune Engager — our weekly pick from the latest immune-engager digest. Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits Cell, 2026 DOI: 10.1016/j.cell.2026.08.002 Question: Can genome-scale CRISPRi perturb-seq in primary human CD4+ T cells, at rest and after stimulation, map which genes regulate T cell states...

Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Predictors and prevalence of support for white nationalism in the United States Nature, 2026 DOI: 10.1038/s41586-026-11018-0 Question: How common is explicit, informed support for white nationalism among white US adults, and what predicts it? Answer: In a probability sample, 4.9% (CI 3.6–6.2) of non-Hispanic wh...

Monday Immune Engager — our weekly pick from the latest immune-engager digest. Discovery and engineering of bispecific TCR-mimic antibodies targeting peptide–HLA complex mAbs, 2026 DOI: 10.1080/19420862.2026.2731282 Question: Can building proteome-wide off-target counter-screening into TCR-mimic antibody discovery yield more specific WT1-targeting bispecifics than published comparators? Answer: Th...

Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Substantial under-detection of human rabies cases in the United States Communications Health, 2026 DOI: 10.1038/s44528-026-00031-4 Question: Using rare transplant-transmitted rabies events as a proxy sample of undiagnosed deaths, how many US rabies deaths does official surveillance actually miss? Answer: Scalin...

Monday Immune Engager — our weekly pick from the latest immune-engager digest. Paper: A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability Authors: M. Frank Erasmus, Daniel Bedinger, Elizabeth Hopkins, Ginger Ferguson, et al. Journal: Nature Biotechnology, 2026 Why it matters: This CASP-style blinded benchmark—testing 511 AI-designed...

Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Paper: Educational expansion and the hidden reversal of the Flynn effect—Differential trends across socioeconomic strata Authors: Bernt Bratsberg, Anders M. Fjell, Ole J. Rogeberg, Kristine B. Walhovd Journal: Proceedings of the National Academy of Sciences, 2025 Why it matters: The apparent plateau and reversa...

Top Trending Friday — our weekly pick of the top-trending paper on r/science this week. Paper: Probability of a timely vocal response in mother-infant interaction and later psychiatric diagnosis: A case-control study Authors: Bethany Stanley, Clare S. Allely, Jenna Charlton, Christopher Gillberg, et al. Journal: PLOS One, 2024 Why it matters: A single timing metric — whether a mother vocalizes bac...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Covalently PD‐L1 Anchoring Drives Bispecific Nanostructure Assembly for Spatial Control of T Cell Recruitment and Activation](https://doi.org/10.1002/anie.5894316) **Authors:** Fengzhen Zhang, Yuhan Dong, Kailu Liu, Hui Hu, et al. **Journal:** Angewandte Chemie International Edition, 2025 **Why it matter...

**Top Trending Friday** — our weekly pick of the top-trending paper on r/science this week. **Paper:** [People prefer to negotiate with women, even when outcomes are identical and gender is unknown](https://doi.org/10.1073/pnas.2523202123) **Authors:** Charlotte H. Townsend, Laura J. Kray, Solène Delecourt **Journal:** Proceedings of the National Academy of Sciences, 2026 **Why it matters:** Decad...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Combination therapy with a novel CD2-targeted costimulatory bispecific antibody overcomes limitations of CD3 T cell engager treatment for solid tumors](https://doi.org/10.1080/19420862.2026.2684378) **Authors:** Welbeck Danquah, Mélanie Pichery, Thomas Eden, Aurelien Boyance, et al. **Journal:** mAbs, 20...

**Top Trending Friday** — our weekly pick of the top-trending paper on r/science this week. **Paper:** [A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone](https://doi.org/10.1038/s41586-026-10546-z) **Authors:** Xiaotong Peng, Peng Zhou, Xikun Song, Giovanni Bianucci, et al. **Journal:** Nature, 2026 **Why it matters:** The discovery of a 1,200-kilometer accumulation of whale...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow](https://doi.org/10.1016/j.ymthe.2026.05.032) **Authors:** SangPhil Ahn, Tae-Sung Oh, Seonghyuk Suh, Joon-Young Jeon, et al. **Journal:** Molecular Therapy, 2026 **Why it matters:** A hybrid computational-experim...

**Top Trending Friday** — our weekly pick of the top-trending paper on r/science this week. **Paper:** [Work from Home and Disability Employment](https://doi.org/10.1257/aeri.20240538) **Authors:** Nicholas Bloom, Gordon B. Dahl, Dan-Olof Rooth **Journal:** American Economic Review: Insights, 2025 **Why it matters:** The post-pandemic rise in remote work appears to have accomplished more for disab...

**Paper:** [From free speech advocates to critics: The Trump administration's new rhetoric promotes support for censorship among Trump voters](https://doi.org/10.1073/pnas.2532084123) **Authors:** Matthew E. K. Hall, B. Tyler Leigh, Brittany C. Solomon **Journal:** Proceedings of the National Academy of Sciences, 2026 **Why it matters:** The study offers rare experimental evidence — using real, no...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial](https://doi.org/10.1038/s41591-026-04455-x) **Authors:** Martin Wermke, Sebastian Ochsenreither, Dirk Jaeger, Heiko Becker, et al. **Journal:** Nature Medicine, 2025 **Why it matters...

**Paper:** [Language Modeling Materializes a World Model of Protein Biology](https://biohub.ai/papers/esm_protein.pdf) **Authors:** Salvatore Candido, Alexander Rives, et al. **Journal:** White paper — Biohub / Evolutionary Scale **Why it matters:** Training a protein language model on billions of diverse metagenomic sequences appears to produce not just pattern matching but an internally organize...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Novel bispecific T-cell engagers overcoming acquired EGFR resistance](https://doi.org/10.1080/19420862.2026.2674236) **Authors:** Lennart Kühl, Ann-Kathrin Löffler, Oliver Seifert, Dennis Michler, et al. **Journal:** mAbs, 2026 **Why it matters:** Acquired resistance to EGFR-targeted antibody therapies r...

**Paper:** [The lived experience of rejection sensitivity in ADHD — A qualitative exploration](https://doi.org/10.1371/journal.pone.0314669) **Authors:** Annabel Rowney-Smith, Beth Sutton, Lisa Quadt, Jessica A. Eccles **Journal:** PLOS One, 2024 **Why it matters:** Emotional dysregulation — and rejection sensitivity in particular — affects the majority of adults with ADHD yet remains largely abse...

**Monday Immune Engager** — our weekly pick from the latest immune-engager digest. **Paper:** [Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery](https://doi.org/10.1038/s41587-026-03128-x) **Authors:** Nan Wang, Hugh Yeh, Ben Lai, Jason Perera, Kevin M. Jude, et al. **Journal:** Nature Biotechnology, 2026 **Why it matters:** Mapping how T...