VJNeurology Podcast

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, and thus far, only efficacious symptomatic treatments have been developed, with PD remaining a progressive disease without a cure. In this week’s podcast Milton Werner, PhD, Inhibikase Therapeutics, Inc., Atlanta, GA; Daniel Otzen, PhD, Aarhus University,  Aarhus, Denmark; Charbel Moussa, MBBS, PhD,  Georgetown Univer...

Headaches in children and adolescents have high incidence and prevalence rates, significantly impacting the quality of life and ability to function in academic and social activities. Our understanding of the pathophysiology of migraine and their diagnosis and treatment have seen remarkable progress over the last years. However, this information comes mainly from studies conducted among adults. In...

New research in rodent models of generalized epilepsy has demonstrated that absence seizures, or brief, sudden lapses of consciousness, can cause abnormal changes in myelin plasticity, maladaptively leading to progressively more seizures. In this podcast we spoke to Juliet Knowles, MD, PhD, Stanford University, Palo Alto, CA, about the research which led to this discovery and the implications this...

In this episode, leading experts Tadeusz Hawrot, Psychedelic Access and Research European Alliance (PAREA); and Ellen James, PhD, Director of Research and Development, Small Pharma, London, UK, discuss new research into psychedelic-assisted therapies and how the views surrounding psychedelics within the medical field are evolving.

Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are chronic conditions of the central nervous system, predominantly affecting women of childbearing age. Hence pregnancy planning is significant in patients with MS and NMOSD. In this podcast, Melinda Magyari, MD, PhD, The Danish Multiple Sclerosis Center, University of Copenhagen, Copenhagen, Denmark; Eva Kubala Havrdová,...

In this podcast, stroke experts discuss the latest updates in recanalization therapy in acute ischemic stroke, highlighting the major debates that have the potential to change clinical practice. Both the value of bridging intravenous thrombolysis and the assessment of intra-arterial thrombolysis after endovascular therapy to improve restoration of microcirculation are discussed. With Urs Fischer,...

In this podcast, Sergio Baranzini, PhD, The University of California San Francisco, San Francisco, CA, discusses our current knowledge of the etiology of MS, the future of genetic studies, and interesting new findings regarding disease progression and the role of the gut microbiome.

In this week’s episode, specialists in the Huntington's disease (HD) field discuss the details of major ongoing studies and give an insight into the implications that their research could have for disease modification and quality of life in HD. The novel agents up for discussion this week are: SAGE-718, a first-in-class oral positive allosteric modulator of NMDAR; pridopidine, an oral sigma-1 rece...

In this podcast, Sanjay Pandey, MD, Govind Ballabh Pant Hospital, New Delhi, India; Carlo Colosimo, MD, FEAN, Santa Maria University Hospital, Terni, Italy; and Marcelo Kauffman, MD, PhD, Hospital JM Ramos Mejia, Buenos Aires, Argentina, will discuss the latest updates in the classification and management of hyperkinetic movement disorders, including iatrogenic disorders, and will also cover the e...

Cenobamate was approved by the FDA in 2019 and the EMA in 2021 for the adjunctive treatment of focal-onset seizures with or without secondary generalization in adult patients. Following its approval, studies have continued to further investigate long-term safety and effectiveness. In this podcast, William E. Rosenfeld and Pavel Klein share new data from open-label extensions and subgroup analyses,...

In this episode, Serge Przedborski, MD, PhD, Columbia University Irving Medical Center, New York, NY; Marina Romero-Ramos, PhD, Aarhus University, Aarhus, Denmark; and Tiago Outeiro, PhD, University Medical Center Göttingen, Göttingen, Germany, discuss novel findings and topics of interest that may lead to the identification of targets for therapeutic interventions in movement disorders.

In this podcast, Matthew Kiernan, MBBS, PhD, DSc, FRACP, FAHMS, University of Sydney, Sydney, Australia; and Nigel Leigh, MBBS, PhD, FRCP, FAAN, FMedSci, University of Sussex, Brighton, UK, discuss crucial developments in our understanding of the underlying mechanisms of ALS, strategies to improve diagnosis and outline the pipeline of late-stage therapeutic options for patients with ALS.

In this podcast, experts discuss the current controversies surrounding the application of endovascular thrombectomy in stroke management and present developments in research regarding patient selection and broadening thrombectomy utilization.

In this episode, James F. Howard, Jr., MD, FAAN, University of North Carolina School of Medicine, Chapel Hill, NC, discusses the results from the open-label extensions of the CHAMPION MG trial (NCT03920293) of ravulizumab and of the ADAPT trial (NCT03770403) that served as a basis for the FDA approval of efgartigimod. The current and future role of complement inhibitor therapy and the knowledge ga...

Experts discuss novel imaging biomarkers in multiple sclerosis and efforts to drive these tools into clinical practice. Jaume Sastre-Garriga, MD, PhD; Vall d'Hebron University Hospital, Barcelona; Pascal Sati, PhD, Cedars-Sinai Medical Center, Los Angeles; Letizia Leocani, MD, PhD, Scientific Institute Vita-Salute University San Raffaele, Milan; and Alberto Calvi, MD, UCL Queen Square Institute of...

Epilepsy specialists talk on the care of women with epilepsy before, during, and after pregnancy, highlighting what they do in their own practice and commenting on new data regarding folic acid, breastfeeding safety, and neurodevelopmental outcomes in children with prenatal anti-seizure medication exposure. Hear exclusively from Marte-Helene Bjork, MD, PhD, Haukeland University Hospital, Norway; B...

During recent neurology conferences, migraine experts have shared noteworthy developments regarding the use of gepants, including clinical trial results, potential new indications, and recent FDA submissions. Explore the most recent updates on the use of gepants from Richard Lipton, MD, Albert Einstein College of Medicine; Stewart Tepper, MD, Dartmouth-Hitchcock Medical Center; and Jessica Ailani,...

In this week’s podcast, movement disorder specialists; Fabrizio Stocchi from IRCCS San Raffaele Rome; Angelo Antonini from the University of Padua; Joaquim Ferreira from the University of Lisbon, and K. Ray-Chaudhuri from King's College London, will discuss recent advances in the use of levodopa and opicapone in Parkinson's disease.

Working at each stage of the process, experts are implementing novel approaches to improve prehospital, in-hospital, and interhospital workflow. In this week’s episode, top stroke specialists discuss their research into streamlining care delivery for stroke patients.

Delve into the minds of leading authorities Mitchell Miglis, MD, Stanford University; Matteo Cesari, PhD, Medical University of Innsbruck; Aleksander Videnovic, MD, Massachusetts General Hospital, Harvard Medical School; and Shady Rahayel, PhD, Montreal Neurological Institute and Hospital, McGill University – as they discuss current updates on isolated RBD.

MOGAD is an inflammatory disorder mainly affecting the optic nerve, spinal cord, and brain. As a result of enhanced clinical testing capabilities, MOG antibodies are being detected in children with central nervous system demyelinating diseases, including pediatric-onset multiple sclerosis (POMS). In this episode, Doctor Amin Ziaei, MD, PhD, University of California – San Francisco, San Francisco,...

In this podcast, David Li-Bland, PhD, Unlearn.ai; Gavin Giovannoni, MBBCh, PhD, FCP, FRCP, FRCPath, Barts and The London School of Medicine and Dentistry, Queen Mary University of London; and Mitzi Joi Williams, MD, Joi Life Wellness Group, discuss potential improvements that can be made to clinical trials in MS: design, efficiency, and ethnic representation.

In this episode, Sabrina Paganoni, MD, PhD, Harvard Medical School, Boston, MA, James F. Howard, Jr., MD, FAAN, University of North Carolina School of Medicine, Chapel Hill, NC, and Jerry Mendell, MD, FAAN, Nationwide Children’s Hospital & Ohio State University, Columbus, OH, discuss key clinical trials in neuromuscular disorders, including the CENTAUR trials in ALS, the Phase III ADAPT trial in m...

In this deep dive into the importance of subtyping in PD, leading authorities Chin-Hsien Lin, MD, PhD, National Taiwan University; Alberto Espay, MD, FAAN, University of Cincinnati, Etienne Hirsch, PhD, Inserm, Sorbonne Université; and Alice Chen-Plotkin, MD, University of Pennsylvania, talk on the limitations of clinical subtyping and why a one-size-fits-all approach to clinical trials is unlikel...

In this episode, Seth Hays, PhD, The University of Texas at Dallas, Dallas, TX, Jesse Dawson, MD, University of Glasgow, Glasgow, UK, and Christian Gerloff, MD, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, review recent breakthroughs in stroke recovery and rehabilitation. Our panel of stroke experts will cover the recent FDA approval of the Vivistim paired vagus nerve stimulation...