VJNeurology Podcast

This episode of the VJNeurology Podcast showcases advances across insomnia, restless legs syndrome, narcolepsy, and sleep apnea from SLEEP 2026. Leading experts discuss updates to the American Academy of Sleep Medicine clinical practice guidelines, trial updates, novel approaches being explored, and more. Featuring insights from Emerson Wickwire, PhD, University of Maryland, Baltimore, MD, Michael...

This episode of the VJNeurology Podcast showcases key trial updates from the American Academy of Neurology Annual Meeting in Chicago, IL. Highlights include orexin receptor agonists for narcolepsy, AMT‑130 in Huntington’s disease, ulixacaltamide for essential tremor, ecopipam for Tourette’s, novel headache agents, and more. Featuring Emmanuel Mignot, MD, PhD, Stanford University School of Medicine...

This episode of the VJNeurology Podcast features a discussion with Prof. Karen Spruyt, PhD, Université Paris Cité, INSERM, NeuroDiderot, Paris, on pediatric sleep disturbances. Prof. Spruyt shares her expert perspectives on the impact of sleep disturbances in children, how to screen for these disturbances, and ongoing research in the field.

This episode focuses on key updates in multiple sclerosis (MS) research from the 11th Annual Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) Forum. We begin with key trial updates, including the FENtrepid (NCT04544449) and MoonStone (NCT06564311) results presented by Amit Bar-Or, MD, FRCPC, University of Pennsylvania, Philadelphia, PA. Le Hanh Hua, MD, Cleveland Clini...

In this episode of the VJNeurology podcast, we are joined by Prof. Mona Nada, MBBCh, MD, Cairo University, Cairo, Egypt, to discuss updates in the prevention, diagnosis, and treatment of cluster headache. Cluster headache is a rare but devastating primary headache disorder, often described as one of the most severe pain conditions in medicine. Characterized by recurrent attacks of severe unilatera...

This episode of the VJNeurology Podcast focuses on the impact of climate change and temperature fluctuations on the management of epilepsy. Anita Arsovska, MD, PhD, University “Ss Cyril and Methodius”, Skopje, North Macedonia, and Medine Gulcebi Idriz Oglu, MD, Marmara University, Istanbul, Turkey, delve into the effects of rising temperatures on seizure frequency, the supply chains of anti-seizur...

In this episode of the VJNeurology Podcast, Jeffrey Dunn, MD, Stanford University School of Medicine, Palo Alto, CA, shares insights from a Phase I trial (NCT06138132) of CAR T-cell therapy for multiple sclerosis (MS). CAR T-cell therapy is a form of adoptive cell transfer that has revolutionized hematologic oncology and is now being investigated as a targeted immunotherapeutic approach for autoim...

In this episode of the VJNeurology Podcast, we’re joined by Krystof Bankiewicz, MD, PhD, The Ohio State University, Columbus, OH, to explore the evolving role of gene therapy in Parkinson’s disease and other neurological disorders. Dr Bankiewicz provides an insightful overview of gene therapies currently in clinical development, highlighting emerging efficacy and safety data from ongoing trials. H...

In this podcast episode, leading experts Kara Melmed (NYU Langone Health, New York City, NY) and Chitra Venkatasubramanian (Stanford University, Stanford, CA) debate blood pressure targets in ICH, focusing on the key question: how low should we go? They discuss the pathophysiological background for lowering blood pressure in ICH, key trial evidence, selecting between agents, and give advice for pr...

Welcome to today's podcast, which focuses on the understanding and management of rare brain disorders. This episode, in honor of Rare Disease Day, delves into a variety of rare neurological conditions, including adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), phenylketonuria (PKU), cerebral autosomal dominant arteriopathy with subcortical infarct (CADASIL), succini...

The 2024 revision of the McDonald diagnostic criteria for multiple sclerosis (MS) was recently presented at the 40th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS 2024). Key updates include the recognition of optic nerve lesions, the incorporation of cerebrospinal fluid (CSF) kappa-free light chains as a diagnostic biomarker, and the addition of centr...

Dopaminergic medications have been widely used in the treatment of restless legs syndrome (RLS), where they are effective at reducing symptoms in the short term. However, long-term use of these agents has been associated with augmentation, a worsening of symptoms over time or earlier in the day. This phenomenon has led to a shift in treatment recommendations, favoring non-dopaminergic options as f...

In recent years, genetic therapies have garnered much attention for their potential to modify the underlying pathological processes in neurological diseases. By correcting, replacing, or removing aberrant genetic material, gene therapies could revolutionize the treatment of many diseases, where symptomatic management is the only available option. Examples of gene therapy methods include the use of...

In this episode, we delve into the complexities of managing status epilepticus, particularly the refractory stages that resist initial treatments. Status epilepticus is a neurological emergency that requires prompt medical intervention to prevent significant morbidity and mortality. Despite aggressive treatment, some cases do not respond to initial lines of therapy. Refractory and super refractory...

Welcome to this episode of the VJ Sounds Podcast, brought to you by the Video Journal of Neurology (VJNeurology). In this podcast, we discuss the important subject of medication overuse headache (MOH). Discover insights into key debates in the field from renowned experts, Prof. Sait Ashina from Harvard Medical School, Prof. Morris Levin from the University of California, San Francisco, Alan Rappap...

The latest guidelines recommend endovascular thrombectomy (EVT) as the gold standard treatment approach for eligible patients with an acute ischemic stroke due to large vessel occlusion, but there is currently no robust randomized control data supporting its routine use in medium vessel occlusion (MeVO) strokes.   In this podcast, stroke experts delve into current uncertainties surrounding the man...

Welcome to our latest episode of the Video Journal of Neurology podcast where we explore the rapidly evolving world of precision medicine within the field of epilepsy. In this episode, we delve into how our emerging understanding of genetic factors is reshaping our knowledge of epilepsy syndromes, shedding light on personalized treatment strategies. Join us as Guido Rubboli, MD; Simona Balestrini,...

Cluster headache, a rare and severe headache disorder, represents the most common trigeminal autonomic cephalalgia. Due to its rarity and often refractory nature, management can be challenging. In this episode, leading experts delve into acute and preventive treatment strategies for cluster headache. Emerging therapies are also discussed, including psilocybin and CGRP-targeted agents.

In this podcast, key opinion leaders Hans Lassman, MD, Medical University of Vienna; Vyanka Redenbaugh, MD, Mayo Clinic College of Medicine; Torge Rempe, MD, PhD, University of Florida College of Medicine; and Kazuo Fujihara, MD, PhD, Fukushima Medical University School of Medicine, give a comprehensive overview of the current research landscape in MOGAD, including its differentiation from MS, dia...

In this podcast, Tiago Outeiro, PhD, University Medical Center Göttingen, Göttingen, Germany; Chia-Chun Chiang, MD, Mayo Clinic, Rochester, MN; and Daniel Goldenholz, MD, PhD, Beth Israel Deaconess Medical Center, Boston, MA, engage in a thought-provoking discussion on the latest developments in AI application. They explore how AI's predictive capabilities could revolutionize basic science, its po...

Neurologists and researchers are increasingly harnessing the power of wearables to gather real-time, high-quality data about patients' neurological conditions. We are joined by leading neurology experts who will share their insights into the diverse applications of wearables in the fields of epilepsy, movement disorders, multiple sclerosis and sleep disorders, offering a glimpse into the future of...

The causative nature of alpha-synuclein (ɑ-syn) accumulation in Parkinson's disease (PD) pathophysiology has been a subject of debate among researchers, ever since its identification in Lewy bodies. In this episode, experts discuss our current understanding of the role of ɑ-syn in PD, as well as the possibility that the loss of normal ɑ-syn function may be more relevant than the accumulation of in...

Biomarker development and discovery have been an important point in multiple sclerosis (MS) research for many years. In this podcast, Elias Sotirchos, MD, Johns Hopkins University School of Medicine, Baltimore, MD; Ferhan Qureshi, VP – Biomarker Product Development, Octave, Menlo Park, CA; and Shane Arsenault, MD, Memorial University of Newfoundland, St. John’s, Canada, discuss recent updates on t...

In this episode, key opinion leaders debate the value of bridging therapy for endovascular thrombectomy following recent reports from several large scale randomized controlled trials. What evidence do we have and what is the best way forward?  With Manon Kappelhof, Johannes Kaesmacher, Urs Fischer, Yvo B. Roos, and Thanh Nguyen.

Narcolepsy is a chronic neurological disorder of rapid onset eye movement (REM) sleep, affecting the sleep-wake cycle in the brain. It is characterized by excessive daytime sleepiness, uncontrollable sleep attacks, and sleep fragmentation and is often associated with cataplexy, sleep paralysis, and hypnagogic hallucinations. In this week’s podcast, Claudio Bassetti, MD, Inselspital, Bern, Switzerl...