To Health With That! MTHFR Mutations and Methylation.

For the first episode of this season on infertility, hormones, and how it all ties in with genetics - let's actually talk about what "infertility" means and why you might have passed some major benchmarks without even knowing it. Meet Dr. Kate Naumes, ND our fertility expert and see Dr. Amy Neuzil, ND in the video version. Watch the video version here: What is Infertility anyway? Visit Dr. Kate at...

The internet is full of doomsday prophecies about MTHFR and vaccines, but what does the actual science say? In this episode we'll cover: Dr. Amy's general views of vaccines MTHFR data in the Vaccine Adverse Event Reporting System in the US MTHFR and the smallpox vaccine research A case report about MTHFR and blood clots after the covid-19 vaccine The controversial issue of vaccines and aut...

Living the MTHFR lifestyle means reducing as much toxic exposure as possible and a lot of that comes through skincare. Today, Dr. Amy is talking with Renee Harris, founder of MadeOn skincare.  You can find Renee's products at hardlotion.com For the complete show notes, click here . To watch the full, 30 minute interview, click here . To meet other folks with MTHFR polymorphisms and get a ton...

Tricia Nelson is an emotional eating expert and the author of Heal Your Hunger: 7 Simple Steps to End Emotional Eating.  I am delighted to have the opportunity to talk with her because emotional eating, while it might sound like a departure for me, is a common problem among us MTHFR folks.   Anyone with MTHFR, COMT fast, or MAO-A fast can be more susceptible than average to emotional eat...

If I had to pick one mutation that was AS pivotal as MTHFR is, it would be PEMT. This mutation affects literally EVERY cell in your body - all 37.2 trillion of them. We'll talk about: The one well studied polymorphism (and the legions of other ones) Signs and symptoms that may point to a PEMT problam How to ease the burden on your PEMT And why it's important to love your liver. Enrollment for the...

This week we'll talk about another gene SNP picture that is called MAO-A Fast. Having a fast MAO-A means you break down neurotransmitters faster than average, and since this gene SNP breaks down Serotonin, Melatonin, Norepinephrine, and Epinephrine you can imagine it leads to quite a lot of self-medication, and the easiest way to self-medicate is with Carbs. So we'll talk about: What is happening...

MAO-A is another gene SNP that is different from the others we've talked about because it is actually linked to a sex chromosome. The various SNPs add up to produce a "fast" or "slow" picture. We'll discuss: Why we can't tell women's MAO-A picture from a genetic report What symptoms to watch for that might indicate you have an MAO-A Slow picture How to manage slow MAO-A naturally Foods to enhance...

Vitamin D doesn't link into the methylation cycle, the folate cycle, or even the BH4 pathway so it seems highly unrelated to MTHFR, but is that true? This week we'll explore: Why vitamin D seems to do literally everything in the research The gene SNPs that affect vitamin D Why folate and vitamin D have relationship status "complicated" How folate and vitamin D might have influenced skin pigment in...

Low histamine isn't something that doctors are talking about yet. It hasn't even really made it to the internet, which is usually first to know everything. But I think there might be more to low histamine states than meets the eye, so let's talk about it. We'll cover: Emerging research on cancer, cardiac disease, and Alzheimer's disease with low histamine Signs and symptoms of low histamine The Ov...

Histamine and MTHFR are joined together in so many ways. Let's talk about: The surprising things other than allergies that histamine influences. Risks and symptoms of high histamine Seven things you can do to lower your histamine naturally. For the complete show notes, click here .  To join Genetic Rockstars - the most incredibly community of MTHFR folks on the internet, click here . To take...

I love listener questions because it's always something good! This week, we talk about: Detoxifying Arsenic Mercury toxicity with adrenal fatigue and MTHFR Amy's quick and dirty about fibromyalgia. If you're looking for this week's show notes, they're here . If you'd like to join Genetic Rockstars you can do that here , and if you want to ask you own question for me to answer on the air, scroll do...

MTHFR is closely tied to heart disease, and nitric oxide (not to be confused with nitrous oxide, or laughing gas) is a big part of the reason why. In this episode we'll talk about: How nitric oxide is linked to heart attacks, strokes, alzheimers, sinus health, mouth breathing, and even some birth defects. Why humming matters How the NOS3 gene affects you and how it interacts with MTHFR How you can...

Of course B12 is important to methylation and MTHFR, but why is that precisely? Well, spoiler alert - it has something to do with two different genes that are also involved in the methionine pathway - MTR and MTRR. So this week, let's talk about: Which gene creates especially difficult to treat issues with homocysteine (especially in combo with MTHFR). What to do about MTR and MTRR polymorphisms W...

We've talked about glutathione before, but now let's talk about two gene SNPs that really mess with your glutathione functioning. We'll discuss: Signs and symptoms of a GST polymorphism Signs and symptoms of a GPX polymoprhism Which SNP is linked to diabetes and early grey hair Which SNP makes walking through the perfume department a nightmare What you can do to help your body get stronger and hea...

We've talked about glutathione before, but let's review before we dive into gene SNPs that affect glutathione. We'll cover: The most common fatal overdose globally (that glutathione can help prevent) The heavy metal that needs glutathione to be taken out of your brain Why glutathione is called the "master antioxidant" Natural ways to boost glutathione Two surprisingly under researched gene SNPs af...

With a COMT Fast picture we see an overly-efficient enzyme that gets rid of crucial substances before they have the chance to act. We'll talk about: The signs and symptoms of a laid-back fast COMT person. Why COMT fast folks absolutely shine in stressful situations. Some COMT fast superpowers. How you can balance your COMT fast for maximum health, happiness, and focus. For the complete show notes...

The COMT slow picture affects neurotransmitters, stress hormones, and estrogen. This week we'll talk about: Signs and symptoms of a slow COMT. How MTHFR ties into the mix. The superpowers that come with a slow COMT Four steps to balancing your COMT picture. Thanks for listening today. For the complete show notes, including links to research, click here . If you want to join the amazing community o...

To kick off our series about other genetic polymorphisms, we're starting with a heavy hitter called COMT. This week we'll talk about: What COMT means, what it does, and why that "M" is so important for MTHFR folks. Why theoretical math on a genetic report might not be as important as your symptoms and personality. What neurotransmitters, hormones, foods, and supplements are affected by this gene S...

MTHFR is not the only gene SNP out there - I know, you'd never know that if you listen to this podcast. So let's start a mini-series about other polymorphisms, but first we need to talk about the perils of deep diving into a genetic report. Genes are not very linear, but then what are they and how can we talk about them in a way that makes sense? There is one really big thing that matters a lot mo...

MTHFR Basic States are an idea that generates a lot of controversy. Some well-respected practitioners don't like to use the idea at all, and some do. So let's talk through Basic States and I'll tell you why I think Basic States are a great concept that is really useful when you're working with MTHFR. We'll talk about Where the idea of basic states came from Why I don't like the terms "undermethyla...

We've talked about so many facets of depression with MTHFR - including the link between MTHFR and neurotransmitter formation, overlooked causes of depression, the mental bad-habit factor, and what to do about those things. What we haven't talked about, are supplements that are MTHFR-safe and also effective. Let's look at three of my favorites. This week we'll talk about: Saffron NAC Rhodiola We'll...

Listeners Liana and Tim asked a couple of great questions this week so let's dive into them. Liana asks about specific product suggestions for 5-LMTHF - we'll talk about what to look for, a few of my personal favorites, and companies that I trust. Tim asks about whether there is or isn't folic acid in Marmite and this sent me down a rabbit hole of questions, so we'll talk through the somewhat ambi...

We haven't touched base about what is happening for you right now with MTHFR, so today is the day. Let's talk: Why we don't need to be changing things constantly What is happening in the background right now The foundational things we need to keep doing through this whole healing journey How often to check in with ourselves How to optimize your dose of methylation drivers We have some amazing stuf...

Last week we talked about the remarkable results 5-LMTHF produced in couples struggling with infertility relative to high-dose folic acid, which is the standard of care.  This week, let's expand on that by looking at some possible risks of high-dose folic acid to those very same pregnancies. First, let's talk about the actual difference to blood levels between high and low dose pregnant women...

5000 mcg folic acid is the standard of care for pregnancies that are considered high-risk and pregnancies in couples struggling with infertility. Unfortunately, many of those couples have MTHFR polymorphisms in one or both partners, and for anybody with MTHFR issues, this is going to actually impair the fertility process and damage their health.  We'll talk about one particular research study...