Dr. Amy Neuzil

To Health With That! MTHFR Mutations and Methylation.

Health EN ↓ 177 episodes

This podcast breaks up BIG health topics, like MTHFR and methylation, into small, easy bites. All in ten minutes or less. We'll discuss why folic acid can be toxic, how the MTHFR enzyme links to estrogen and toxins, why you want to turn genes off, and how folate and mental health are connected. 2024-2025 will add new "bonus" episodes to Season 1 to clarify and revise concepts while Dr. Amy is writing a book. Check linked blogs at tohealthwiththat.com for more info and downloadable. Join us in Genetic Rockstars, our MTHFR, methylation community now at community.tohealthwiththat.com

Author

Dr. Amy Neuzil

Category

Health

Podcast website

tohealthwiththat.com

Latest episode

Apr 19, 2026

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Episodes

KCs MTHFR Story 2: MTRR, Vitamin B12, and Hypothyroid. 19.04.2026

KC is kind enough to share her story about MTHFR and POTs, or postural orthostatic tachycardia syndrome, MTRR, and hypothyroid. This was a long interview, so it has been broken up into two podcast episodes. 00:49 - Meet KC 00:37 - MTRR and Vitamin B12 01:48 - MTHFR, MTRR, and homocysteine levels 02:31 - Red flags for vitamin B12 deficiency 04:26 - Hypothyroid 05:30 - Naturopathic medicine 08:26 -...

KC's MTHFR and POTS, or Postural Orthostatic Tachycardia Syndrome Journey 05.04.2026

KC was kind enough to share her story of MTHFR, POTs, or postural orthostatic tachycardia syndrome. This was a long interview, so it has been broken up into two podcast episodes. 00:49 - Meet KC01:18 - POTS diagnosis02:07 - POTS and COVID-1902:58 - POTS and MTHFR 06:22 - Giving up folic acid06:49 - Symptoms of folic acid detox07:17 - Methylated vitamins09:03 - Health knowledge is power09:18 - Unde...

Laura's MTHFR Story - Psoriasis, autoimmunity, and endometriosis. 22.03.2026

Laura bravely shares the story that has shaped her life in so many ways. Psoriasis, endometriosis, and multiple hospitalizations with a layer of MTHFR gene mutation underneath. Watch to see how Laura has mastered her own health, her own path, and her journey forward for herself and her family.00:00 - Intro00:39 - Laura's story - psoriasis, psoriatic arthritis, and more.01:44 - Stage 4 endometr...

Monica's MTHFR Story - PCOS, Hives, and Histamine 08.03.2026

Monica was kind enough to share her health story with us, starting with a PCOS diagnosis, then thyroid antibodies, then uncontrollable hives, and finally to some relief when she found out about MTHFR and started working on her methylation. This is the full-length interview. MTHFR stories have so much variety, but there are common threads and hormone imbalance, inflammation, and histamine are defin...

Jesse's MTHFR Story - Mold Injury and Detoxification 22.02.2026

Jesse generously shares his story of MTHFR, chemical sensitivity, and mold injury. Mold illness can affect many people with MTHFR because of our slower detoxification abilities, so mold injury and chemical sensitivity are common threads in the MTHFR journey. Jesse talks about mold remediation, herxheimer reactions, chemical sensitivity, and methylation.00:00 - Intro00:34 - Jesse’s strange symptoms...

Christa's MTHFR Story - Amazing Son Helps Her Son Beat His Developmental Delay 18.01.2026

Christa generously shares the story of how discovering MTHFR and detoxifying completely changed the trajectory of her son's life, and their family's attention to nutrition. Christa's son struggled with communication, attention, memory, sensory issues, and what was diagnosed as developmental delay. Thanks to Christa's hard work with eliminating folic acid and using detoxification su...

Kelsey's MTHFR Story - Hormones, blood sugar and hemochromatosis. 21.12.2025

Today, Kelsey is kind enough to share her and her family's journey with MTHFR. Like the rest of us, their journey has unfolded slowly with a lot of personal research along the way.00:00 - Intro00:38 - Meeting Kelsey01:11 - How she found out about MTHFR02:18 - Quest to learn about MTHFR03:23 - High dose folic acid in pregnancy and pregnancy complications04:09 - The MTHFR highlights - ADHD, diff...

Betsy's MTHFR Story - Rheumatoid Arthritis, methotrexate, and MTHFR 07.12.2025

Season 5, Episode 7 of the To Health With That! podcast. Betsy and I recorded this video several years ago (hence the hair!) and she was kind enough to consent to share it in this format as well. Betsy's history as a nurse gives her a wonderful, insightful perspective on healthcare and her journey with autoimmune disease and having to take an antifolate will help so many other individuals who...

Kristyn's MTHFR Story - Fatigue, Anxiety, Pericarditis 23.11.2025

Thank you so much to Kristyn for sharing her MTHFR story with us. Kristyn has only known she had an MTHFR gene variant for three months, but it makes sense of many of the symptoms she has had her whole life like fatigue, difficulty sleeping, and anxiety. MTHFR could be contributing to her recurrent pericarditis and kidney disease. Kristyn shares her journey with diet and supplements and trying to...

Tony's MTHFR Story Part 2 - Tumors, surgery, and anesthesia with MTHFR 09.11.2025

To Health With That! Podcast Season 5, Episode 5. Thank you so much to Tony for generously sharing his story - the full interview was fabulous and included much more than we could put in one podcast episode, so we broke it into two. In this episode, Tony continues to share with the idea of MTHFR being a rebirth, new information he has about a tumor and his concerns about folate and tumor growth, a...

Tony's MTHFR Story - Part I. Anxiety, overwhelm, methyl folate intolerance 26.10.2025

To Health With That! Podcast Season 5, Episode 4. Thank you so much to Tony for generously sharing his story - the full interview was fabulous and included much more than we could put in one podcast episode, so we broke it into two. In this episode, Tony shares his frustration at feeling bad, but doctors telling him he's "normal", the relief at finding MTHFR, which makes his symptoms...

Karene's MTHFR Story - ADHD, Sensitivity and Nutrient Deficiency 12.10.2025

Thank you so much to Karene for generously sharing her story! Karene is new to MTHFR - she just found out that she and her children have an MTHFR gene mutation one week ago. Karene tested because of ADHD for herself and one of her sons, and is just starting to learn about the gene SNP and what to do. 00:30 - Introducing Karene01:03 - ADHD diagnosis01:39 - Why MTHFR explains so much for her son02:1...

Mary's MTHFR story - MTHFR and repeat pregnancy loss. 28.09.2025

MTHFR Stories are interviews with regular people who have MTHFR and are willing to share their health journey to help others. Mary's MTHFR journey centers around pregnancy loss with several second-trimester miscarriages and a stillbirth. She bravely talks about the exhaustion that she has struggled with after such a deep physical toll was taken on her body by the pregnancies, and the emotional...

Lisa's MTHFR story - perfection, MTHFR, and self-acceptance 07.09.2025

Lisa's story is a testament to what having a community of people can do for your health journey. Lisa touches on many familiar MTHFR issues - allergies, impatience, food sensitivities, blood sugar imbalance, struggles with weight, lip tie, and perfectionism. Her biggest hurdles on this journey have been about self-acceptance and also learning to have patience and not over-push her body. She is...

What is Happening In Season Five? YOU'RE COMING ON THE PODCAST! 20.07.2025

The To Health With That! Podcast for MTHFR folks has been a wild ride, but so far it's really just Dr. Amy talking about MTHFR.In Season Five, which will start airing in September, I want YOU to talk. Tell me about your experience of being a person with MTHFR gene mutations, tell me what has helped you, what hasn't been helpful, and what you want all the other MTHFR folks out there to know...

Methylation Adaptogens, or Proof that God Loves Us. 01.06.2025

In the last episode, we talked about CBD as a methylation adaptogen, but we haven' talked too much about that term so let's dive in. We know that everyday methylation is important for people with the MTHFR gene or with any methylation dysfunction, but it turns out that long-term methylation care is important too and this can be achieved by getting methylation adaptogens. Methylation adapto...

MTHFR and Marijuana. - What We Know Now. 27.04.2025

Pot is the third most used drug in North America after alcohol and tobacco, so questions about Cannabis and MTHFR are important to ask. The answers, of course, are mixed with some serious pitfalls and also some surprising benefits of CBD for people with MTHFR gene mutations. Nothing is ever fully good or fully bad, and marijuana for MTHFR is the same. When you have an MTHFR gene variant, it is imp...

The Artist and The Activist Methylation Personality Types 16.03.2025

Methylation imbalance and the causative factors leading to methylation imbalance, like the MTHFR gene mutation, show themselves in four distinct personality types. These methylation personality types, methylation archetypes, or MTHFR personalities are called The Achiever, The Athlete, The Activist, and The Artist. The Activist and The Artist are very closely linked. Neither are terribly ambitious...

The Achiever and The Athlete Personality Types 23.02.2025

,Methylation imbalance and the causative factors leading to methylation imbalance, like the MTHFR gene mutation, shows itself in four distinct personality types. These methylation personality types, methylation archetypes or MTHFR personalities are called The Achiever, The Athlete, The Activist, and The Artist. The Achiever and The Athlete are very closely linked. Both are extremely ambitious, per...

Discover Your Methylation Personality: Achiever, Activist, Artist, Athlete. 12.01.2025

Methylation imbalance, often caused by the MTHFR gene mutation, by folic acid excess, or by nutritional deficiencies, shows itself in several personality traits. Some personality traits are common to people with methylation dysfunction, like perfectionism, OCD-tendencies, anxiety, hyper-focus or hypo-focus, and others. These common traits emerge in each methylation archetype pattern in slightly di...

Are Overmethylator and Undermethylator Still Useful Terms? 22.12.2024

I have used the terms over methylator and undermethylation in the past to help categorize people to streamline their supplement start with MTHFR or other methylation imbalance, but the terms themselves can be confusing and misleading because they imply a biochemical state that isn't actually there. Logically, it makes sense that an undermethylator would be globally undermethylating things, but...

How Much Methyl Folate is Too Much for MTHFR? 17.11.2024

She breaks down the considerations for symptom management and potential risks, particularly regarding tumors and blood labs. In this episode of 'To Health With That,' naturopathic doctor Amy Neuzil discusses the complexities surrounding methylfolate dosing for individuals with MTHFR. High doses of methylfolate could come with some of the same risks as high-dose folic acid, so it's esse...

The Risks of High Dose Folate 20.10.2024

Folate is a great thing - it's vitamin B9 and your body needs it to make new cells, replicate DNA, and so much more. But there are risks of too much folate, so how much folic acid is too much? And how dangerous is it to take high dose folic acid over time? The research exists for high dose folic acid, but what about L-5MTHF, or methyl folate? Does high dose methyl folate have the same risks as hig...

What's Happening With The THWT Podcast in September? 14.07.2024

That's right - season 4 of the To Health With That podcast is finished, so let's talk about what you should be doing this summer (having fun), what I should be doing in the fall (writing), and what kind of episodes you can expect. I'd like to call it To Health With That! Season One BONUS Episodes. Thanks so much for being here and adding so much in terms of comments and questions - I c...

Gentle Six Week Detox For MTHFR 30.06.2024

Gentle MTHFR Detox ProtocolA gentle six-week detoxification protocol tailored for individuals with MTHFR polymorphism. She explains how decreased methylation in MTHFR polymorphism sufferers leads to toxin accumulation and stresses the importance of detoxification. The protocol includes preparatory steps, recommended supplements like NAC and liposomal glutathione, dietary adjustments, and lifestyle...

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