Star Update Podcast - Cardiology News Summaries

A novel score to predict in-hospital mortality for patients with acute coronary syndrome and out-of-hospital cardiac arrest: the FACTOR study Clin Res Cardiol . 2024 Feb 8. doi: 10.1007/s00392-023-02367-1.   Abstract Introduction : Acute coronary syndromes (ACS) represent a substantial global healthcare challenge. In its most severe form, it can lead to out-of-hospital cardiac arrest (OHCA). Despi...

The Prognostic impact of treatments evolution in STEMI Int J Cardiol. 2024 Jan 1:394:131352. doi: 10.1016/j.ijcard.2023.131352   Abstract Objective: To evaluate in a real-world primary percutaneous coronary intervention (pPCI) registry the impact of the evolution of evidence-based treatments on prognosis.   Methods: STEMI patients undergoing pPCI at the University Hospital of Trieste, Italy, were...

One year clinical outcome of dual anti-platelet therapy with the Novel Ticagrelor plus Aspirin versus Clopidogrel plus Aspirin for Endovascular Intervention of patients with Intracranial Aneurysm: A meta-analysis J Stroke Cerebrovasc Dis. 2024 Jan;33(1):107491. Abstract Background : The use of stents to treat un-ruptured intracranial aneurysms was first approved in the year 2002 in the United Stat...

Beta-blocker therapy in heart failure with preserved ejection fraction (B-HFpEF): a systematic review and meta-analysis Curr Probl Cardiol . 2024 Jan 4:102376. doi:10.1016/j.cpcardiol.2024.102376. Abstract Introduction: While beta-blockers are considered the cornerstone of treatment for heart failure with reduced ejection fraction, the same may not apply to patients with heart failure with preserv...

Predictive value of the thrombotic risk criteria proposed in the 2023 ESC guidelines for the management of ACS: insights from a large PCI registry Eur Heart J Cardiovasc Pharmacother. 2024 Jan 5;10(1):11-19. doi: 10.1093/ehjcvp/pvad069 Abstract Aim: To assess the value of the thrombotic risk criteria proposed in the 2023 guidelines of the European Society of Cardiology (ESC) for the management of...

Emergent use of ticagrelor during endovascular reperfusion in large arterial occlusions   J Stroke Cerebrovasc  Dis . 2023 Dec;32(12):107351. doi: 10.1016/j.jstrokecerebrovasdis.2023   Abstract Objective : Given many emerging indications for endovascular interventions in ischemic strokes, a safe and effective adjuvant antiplatelet regimen for acute revascularization has become a subject of interes...

Effect of beta-blockers and exercise restriction on the prevention of sudden cardiac death in pediatric hypertrophic cardiomyopathy JCardiol. 2023 Dec 2:S0914-5087(23)00288-5. doi: 10.1016/j.jjcc.2023.11.009.   Abstract Background: Risk assessment tools and effective prevention strategies for sudden cardiac death (SCD) in pediatric patients with hypertrophic cardiomyopathy (HCM) have not been esta...

De-escalation of Antiplatelet Therapy After Percutaneous Coronary Intervention in East Asian Patients   With   Acute Coronary Syndrome  Clin Ther. 2023 Dec 8:S0149-2918(23)00305-3. doi: 10.1016/j.clinthera.2023.08.004   Abstract Purpose: East Asian individuals have a lower risk of thromboembolic events while potentially carrying a higher risk of bleeding events compared with non-Asian individuals....

Prognostic significance of medical therapy in patients with heart failure with reduced ejection fraction  ESC Heart Fail. 2023 Dec;10(6):3677-3689. doi: 10.1002/ehf2.14559   Abstract Aims: The use of guideline-directed medical therapy (GDMT) among patients with heart failure (HF) with reduced ejection fraction (HFrEF) remains suboptimal. The SMYRNA study aims to identify the clinical factors for t...

A new meta-analysis of the two trials showed that "oral anticoagulation with edoxaban or apixaban reduces the risk of ischemic stroke by approximately one-third and increases major bleeding by roughly double.   In absolute numbers, there were three fewer ischemic strokes per 1000 patient years with anticoagulation in the two trials combined, at the cost of seven more major bleeds.   I n patie...

People who followed a low-salt diet for just a week experienced a reduction in systolic blood pressure of about 6 mm Hg, in a new study. Raised blood pressure contributes to 1 out of every 8 deaths worldwide. "If people want to lower their blood pressure, attention to dietary sodium is one part of that. If individuals can stick with a low sodium diet, they may be able to stop taking one of th...

Aspirin may not be necessary or beneficial in patients with advanced heart failure who get a left ventricular assist device (LVAD), new randomized results suggest. "We've always thought that somehow aspirin prevents stroke and prevents clotting and that it's anti-inflammatory, and what we found in ARIES was the exact opposite," said Mandeep Mehra, MD, of Brigham and Women's Hos...

In patients with myocardial infarction (MI) and anemia, a "liberal" red blood cell (RBC)transfusion strategy significantly reduce the risk of recurrent MI or death within 30 days compared with a "restrictive" transfusion strategy, in the 3500-patient MINT trial. A liberal transfusion strategy may be the most prudent approach to transfusion in anemic patients with MI We cannot cl...

β1-blockers in the reduction of bleeding risk in patients prescribed with potent dual antiplatelet therapy after acute coronary syndrome or percutaneous coronary intervention Hellenic J Cardiol. 2023 Oct 12:S1109-9666(23)00188-4. doi: 10.1016/j.hjc.2023.09.017   Abstract Background: β1-blockers could improve clinical outcomes in patients with coronary artery disease by lowering the heart rate, blo...

Comparison of Ticagrelor Monotherapy and Ticagrelor Plus Aspirin Among Patients With Acute Coronary Syndrome Combined With High-Risk of Gastrointestinal Bleeding After PercutaneousCoronary Intervention: A Retrospective Cohort Study J Cardiovasc Pharmacol. 2023 Oct 1;82(4):327-332. doi: 10.1097/FJC.0000000000001461 Abstract To date, no studies have specifically examined the efficacy of P2Y12 inhibi...

Sex and Age Differences of Major Cardiovascular Events in Patients After Percutaneous Coronary Intervention J Chin Med Assoc . 2023 Oct 10. doi: 10.1097/JCMA.0000000000001011 Abstract Background : Women usually have higher risk after receiving percutaneous coronary interventions (PCIs) than men with coronary artery disease (CAD). The aim of this study was to investigate the association of sex diff...

Effectiveness and Safety of P2Y12 Inhibitor Pretreatment for Primary PCI in STEMI: Systematic Review and Meta-analysis J Cardiovasc Pharmacol. 2023 Oct 1;82(4):298-307. doi: 10.1097/FJC.0000000000001460   Abstract Dual antiplatelet therapy with aspirin and P2Y12 inhibitors in patients with ST-segment elevation myocardial infarction (STEMI) has been shown to be associated with better outcomes. Yet,...

Effect of ticagrelor and clopidogrel dual antiplatelet therapy on MPVLR, MAADP, and AA inhibition rate in acute coronary syndrome patients after percutaneous coronary intervention  Medicine(Baltimore). 2023 Sep 15;102(37):e34974.   Abstract Objective: To explore the effects of ticagrelor and clopidogrel dual antiplatelet therapy on the mean platelet volume-to-lymphocyte ratio (MPVLR), maximum ampl...

   Factors associated with complications in ST-elevation myocardial infarction: a single-center experience BMC Cardiovasc Disord 2023 Sep 19;23(1):468.   Abstract Background: ST-elevation myocardial infarction (STEMI) is a major public health problem. This study aimed to determine the prevalence and identify the determinants of STEMI-related complications in the Cardiology Intensive Care Unit of t...

Short-Term DAPT and DAPT De-Escalation Strategies for Patients With Acute Coronary Syndromes: A Systematic Review and Network Meta-Analysis Circ Cardiovasc Interv. 2023 Sep;16(9):e013242 Abstract Background : Short-term (≤6 months) dual antiplatelet therapy (DAPT) and DAPT de-escalation become attractive for patients with acute coronary syndrome.   Methods: A systemic search identified randomized...

Heart failure pharmacological treatments and outcomes in heart failure with mildly reduced ejection fraction Eur Heart J Cardiovasc Pharmacother. 2023 Sep 20;9(6):526-535.   Abstract Background: Guideline recommendations for the treatment of heart failure with mildly reduced ejection fraction (HFmrEF) derive from small subgroups in post-hoc analyses of randomized trials.   Objectives: We investiga...

Metoprolol or Verapamil in the Management of Patients With Hypertrophic Cardiomyopathy: A Systematic Review Cureus. 2023 Aug 9;15(8):e43197   Abstract Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease and is a prevalent cause of sudden cardiac death (SCD). This study aims to establish the benefits and therapeutic value metoprolol or verapamil offer to patients who suffer f...

  Comparative Effectiveness of Long-Term Maintenance Beta-Blocker Therapy After Acute Myocardial Infarction in Stable, Optimally Treated Patients Undergoing Percutaneous Coronary Intervention J Am Heart Asso. 2023 Aug;12(15): e028976    Abstract Background The benefits of long-term maintenance beta-blocker (BB) therapy in patients with acute myocardial infarction (AMI) undergoing percutaneous coro...

Early Effects of Ticagrelor Versus Clopidogrel on Peripheral Endothelial Function After Non-ST-Elevation Acute Coronary Syndrome and Assessment of Its Relationship With Coronary Microvascular Function Am J Cardiol. 2023 Aug 15; 201:16-24     Abstract Peripheral endothelial dysfunction is an independent predictor of adverse long-term prognosis after acute coronary syndrome. Data are lacking on the...

Prognostic factors in young patients with ST-segment elevation myocardial infarction Coron Artery Dis. 2023 Aug 1;34(5):298-305.   Abstract Objective: The prognostic factors of young patients aged ≤40 years with ST-segment elevation myocardial infarction (STEMI) remain unclear. This study explored risk factors that may affect the 1-year prognosis of young STEMI patients by analyzing patient data o...