Pharmacy to Dose: The Critical Care Podcast

ACORN: Rapid Reaction Special Guests: Michael Behal, PharmD, BCCCP Joanna Stollings, PharmD, FCCP, FCCM, BCPS, BCCCP Michael Behal joins me to review the recently published ACORN trial from JAMA. We highlight the background of antibiotic-associated AKI, review the trial methodology and results, dive into the supplement and talk about duration of treatment, empiric v. targeted treatment, have defin...

Pharmacy to Eat: Food Recommendations and Life Update  HAPPY THANKSGIVING! 03:19 – Indianapolis: Nick Peters 04:50 – Boston: Grace Erdman 05:55 – New Haven: Steve Lemieux and Kelly Oldziej 08:30 – Buffalo: Nick Servati 10:33 – New York: Karen Berger and Peter Nikolos 12:58 – Philadelphia: Ashley Barlow, Brooke Barlow, Sara Groome, Alyssa Meester, and Todd Miano 19:31 – Maryland: Mojdeh Heavner and...

2023 ACCP Annual Meeting Recap Conference Correspondent: Anthony Hawkins, PharmD, FCCM, BCCCP Anthony’s travel day, Dallas airport comparison and city review, poster hall likes/dislikes, unique and notable clinical sessions, favorite titles, Critical Care PRN business meeting highlights, award winners, FCCP awardees, correcting a last name mispronunciation, #MakePharmacyLessFormal and much more. ...

2023 ACCP Annual Meeting Day 1 & 2 Mini Recap Nick discusses his highlights, thoughts, and even suggestions from Day 1 & 2 of the 2023 ACCP Annual Meeting in Dallas, TX. https://www.accp.com/meetings/am23/index.aspx @PharmacyToDose PharmacyToDose@Gmail. Com PharmacyToDose.com Learn more about your ad choices. Visit megaphone.fm/adchoices

AVP: All Vasopressin Podcast Special Guests: Seth Bauer, PharmD, FCCM, FCCP, BCCCP Gretchen Sacha, PharmD, BCCCP 05:42 – Historical use/mechanism of action 14:00 – Septic shock guideline recommendations 18:45 – When to add vasopressin? 26:55 – Vasopressin dosing 38:52 – Predicting vasopressin response 48:55 – Use in special populations 61:25 – Discontinuation 67:39 – Cost considerations 72:48 – Us...

Trial of the Week: Rivers EGDT in Sepsis Special Guest: Rob Maclaren, PharmD, MPH, MCCM, FCCP I’m joined by Rob Maclaren to discuss the 2001 NEJM study “Early goal-directed therapy in the treatment of severe sepsis and septic shock.” We discuss the historical care of sepsis, mortality rates prior to this study, and use of critical care bundles before highlighting all the findings from the Rivers E...

2023 North American Congress of Clinical Toxicology (NACCT) Pharmacist-featured Research Highlights 02:36 –  “Association between daily high temperature and copperhead envenomations reported to a regional poison center” ft. Jimmy Leonard, PharmD, DABAT 18:22 – “Persistent complications following snake envenomation: results of a specialized snake post-discharge clinic” ft. Erin Ryan, PharmD 31:56 –...

CRRT Trials of the Week: RENAL & IDEAL-ICU  Special Guest: Linda Awdishu, PharmD, MAS Linda Awdishu joins me to highlight two landmark studies related to the use of continuous renal replacement therapy (CRRT) in the critically ill. We discuss renal replacement therapy, compare modalities, and review the history of CRRT as an introduction. Then we review two studies: “Intensity of Continuous Renal-...

Pulmonary Hypertension Part II Special Guest: Zach Smith, PharmD, BCPS, BCCCP, FCCP 04:03 – Intro/Diagnosis/Classification 14:30 – Treatment overview 24:00 – CCB 30:30 – PDE5i/ERA/GCS 40:00 – Prostacyclins  46:40 – RV failure in the ICU 64:30 – Role of PharmD/Take-home points Reference List: https://pharmacytodose.files.wordpress.com/2023/10/pulmonary-hypertension-part-ii-references.pdf PharmacyTo...

Trial of the Week: AID-ICU Special Guest: Grace Erdman, PharmD Grace Erdman, 2023 Pharmacy to Dose Award Winner, joins to discuss “Haloperidol for the treatment of delirium in ICU patients: AID-ICU trial” published in NEJM in 2022. We review studies that led to the AID-ICU study, discuss difficulties with delirium research, deep-dive into the AID-ICU trial, compare treatment in hyper-, and hypoact...

Trial of the Week: SPLIT Special Guest: Anthony Hawkins, PharmD, FCCM, BCCCP Anthony Hawkins joins me to highlight the “Effect of a Buffered Crystalloid Solution vs. Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial” published in JAMA.  We compare the composition of different crystalloids, review pertinent trials published prior to this st...

Trial of the Week: CRASH-3 Special Guest: Ruben Santiago, PharmD, BCPS, BCCCP Ruben Santiago joins me to discuss the landmark article “Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3)” published in Lancet. We review the history of TXA use in trauma, what the CRASH-3 study ultimately found, how d...

Literature Review Series July 2023 Special Guests: Chris Bollinger, PharmD, MBA Hannah Davis, PharmD 04:05 – Featured Articles 44:35 – Cardiology 60:30 – Hematology 65:20 – Pulmonary 76:00 – PharmD 82:27 – Grab Bag Reference List: https://pharmacytodose.files.wordpress.com/2023/10/july-lrs-2023-references.pdf PharmacyToDose. Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad c...

Trial of the Week: UFH v. LMWH for Trauma VTE Prophylaxis Special Guest: Brandon Hobbs, PharmD, BCPS, BCCCP, FCCM Brandon Hobbs joins to discuss the landmark article “A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma” published in the New England Journal of Medicine.  We review the history of VTE prophylaxis in traum...

Extracorporeal Cardiopulmonary Resuscitation (ECPR)  Special Guests: Caitlin Brown, PharmD, BCCCP, FCCM Patrick Wieruszewski, PharmD, BCCCP 04:22 – Definition/History of use 06:48 – ECPR vs. ACLS 11:40 – ECPR research 22:00 –VA ECMO overview 24:02 – Ideal patients/Contraindications 30:52 – ECPR overview from presentation to cannulation 41:15 – Pharmacotherapy in longer ECPR cardiac arrests 49:00 –...

Trial of the Week: Impact of Pharmacists & MRC-ICU Score Special Guest: Andrea Sikora, PharmD, MSCR, BCCCP, FCCM Andrea Sikora joins me to discuss her study “Impact of Pharmacists to Improve Patient Care in the Critically Ill: A Large Multicenter Analysis Using Meaningful Metrics with the MRC-ICU Score” published in Critical Care Medicine.  We review what the MRC-ICU scoring tool is, evidence up t...

Acute Coronary Syndromes (ACS) Special Guest: Nick Servati, PharmD, BCCP 04:55 – Pathophysiology/Clinical presentation 12:40 – “MONA” myths 20:05 – P2Y12 pretreatment 24:25 – Thrombolytics in ACS 30:35 – Anticoagulation 38:55 – Vasopressors/Inotropes 49:50 – IV antiplatelet agents 60:10 – STEMI pharmacotherapy checklist 66:00 – Future research/Take-home points Reference List: https://pharmacytodos...

Literature Review Series June 2023 Special Guest: Beau Blake, PharmD 03:50 – Featured Articles 30:40 – Cardiology 43:10 – PADIS 48:15 – Prostacyclins 51:20 – Infectious Diseases  63:10 – PharmD 70:15 – Grab Bag Reference List: https://pharmacytodose.files.wordpress.com/2023/09/june-lrs-2023-references.pdf PharmacyToDose. Com  @PharmacyToDose  PharmacyToDose@Gmail.com Learn more about your ad choic...

Trial of the Week: Linezolid v Daptomycin in VRE BSI Special Guest: Nick Britt, PharmD, MS, BCPS, BCIDP Nick Britt joins to highlight his first-author research comparing the use of linezolid v. daptomycin for treatment of vancomycin-resistant Enterococcus bloodstream infection (VRE BSI) published in Clinical Infectious Diseases in 2015. We review what the standard of care was for treatment at this...

2023 Neurocritical Care Society Annual Meeting Pharmacist-featured research 02:24 – Multicenter comparison of the safety and efficacy of clopidogrel versus ticagrelor for neuroendovascular stents featuring Casey May, PharmD, BCCCP, FNCS 15:24 – Prevalence of augmented renal clearance in neurocritical care population: a prospective multicenter study (Neuro-ARC study) featuring Sherif Mahmoud, BSc (...

2023 Pharmacy to Dose Award Winner Celebration 08:04 – Deborah Wagner, Publication of the year winner 11:35 – Megan Rech, Mentor of the year winner 13:32 – Brian Gilbert, Conference speaker of the year winner 15:45 – Melissa Thompson Bastin, Preceptor of the year winner 18:14 – Alyssa Meester and Adam Smith, Tag Team Tandem of the year winner 21:54 – Grace Erdman, PGY2 resident of the year winner...

Trial of the Week: Phenobarbital for Acute Alcohol Withdrawal Special Guest: Joseph Lam, PharmD Joseph Lam joins me to highlight the 2013 trial published in the Journal of Emergency: Phenobarbital for acute alcohol withdrawal: a prospective, randomized, double-blind, placebo-controlled study. Joe shares his experience in the trial and all he did behind the scenes. Plus, we discuss the role of phen...

Arrhythmias in the Emergency Department Special Guests: Kyle DeWitt, PharmD, BCPS Lance Ray, PharmD, BCPS, BCEMP 05:30 – Intro/background 10:10 – Atrial arrhythmias 56:40 – EKGs/Ventricular arrhythmias 72:35 – Bradyarrhythmias/take-home points Reference List: https://pharmacytodose.files.wordpress.com/2023/09/arrhythmias-in-the-ed-references.pdf PharmacyToDose. Com  @PharmacyToDose  PharmacyToDose...

Trial of the Week: ATHOS-3 Angiotensin II for the Treatment of Vasodilatory Shock Special Guest: Dr. Ashish Khanna, MD, MS, FCCP, FCCM, FASA Dr. Ashish Khanna joins me to highlight the ATHOS-3 trial, where Dr. Khanna is the principal investigator and first author of the NEJM publication. We discuss the history of angiogensin II, research prior to ATHOS-3, highlight findings from the ATHOS-3 trial,...

Trial of the Week: Insidious Harm of Medication Diluents Special Guest: Carolyn Magee Bell, PharmD, BCCCP Carolyn Bell joins me to discuss her first author research study, the Insidious Harm of Medication Diluents. We review what the perception around balanced fluids was in 2016, advice for prospective research, ultimate trial take-aways, things she would do different, bribing other Pharmacists, a...