Peptides Explained

Description Can a tiny peptide discovered nearly 50 years ago hold the key to better sleep? In this episode of Peptides Explained , we explore Delta Sleep-Inducing Peptide (DSIP) —one of the most mysterious compounds in peptide research. Unlike many peptides discussed today, DSIP has no confirmed receptor, conflicting clinical data, and decades of unanswered questions. In this episode you'll l...

5-Amino-1MQ is often talked about in peptide circles, but it is not actually a peptide. It is a small-molecule NNMT inhibitor being studied for its potential role in nicotinamide metabolism, NAD⁺ biology, methylation, fat-cell function, insulin sensitivity, and liver metabolism. In this episode, John Garrett breaks down the proposed mechanism behind 5-Amino-1MQ, why people are discussing it for fa...

BPC-157 & TB-500 for Dogs: Healing, Recovery & the Current Science Welcome to Episode 1 of the Peptides Explained Veterinary Series. In this episode, we examine two of the most talked-about peptides in regenerative veterinary medicine— BPC-157 and TB-500 . We'll discuss what researchers currently know about these experimental peptides, why they're generating interest among veterina...

I asked ChatGPT a simple question... and the answer surprised me. For Research Grade Peptides, check out Offline Peptides 🌐 ⁠OfflinePeptides.com/Ref/JohnGarrett⁠ If ChatGPT were a 47-year-old peptide researcher who needed to lose 40 pounds, had a nagging knee injury, wanted to preserve muscle, improve energy, and had an unlimited budget, what peptide stack would it choose? Instead of recommending...

Can a peptide actually slow the aging process? In this episode of Peptides Explained , we take a deep dive into Epitalon —one of the most talked-about peptides in longevity medicine. You'll learn: What Epitalon is and where it came from How telomeres and telomerase work Why the pineal gland may play a role in aging What the human and animal research actually shows Why activating telomerase is...

SS-31 (Elamipretide) may be one of the most fascinating peptides ever developed. Unlike most peptides that work by activating receptors on the surface of cells, SS-31 targets the mitochondria—the cellular power plants responsible for producing energy. In this episode of Peptides Explained , we break down: ✅ What mitochondria actually do ✅ The role of cardiolipin in cellular energy production ✅...

Most peptide users understand what peptide they want to use, but many struggle with the math behind vial size, reconstitution, concentration, units, volume, and medication calculations. In this episode of Peptides Explained, we break down the fundamentals of peptide math in plain English. You'll learn the difference between total vial contents and dose, what reconstitution actually means, why...

What do tanning peptides have to do with sexual medicine? More than you might think. In this episode of Peptides Explained, we explore the fascinating science behind Melanotan I, Melanotan II, and PT-141 (Bremelanotide). What began as research into skin pigmentation and UV protection unexpectedly led to the development of an FDA-approved medication for hypoactive sexual desire disorder. You'll...

The founder of Offline Peptides joins Peptides Explained for a candid discussion about grey market peptides, quality control, regulation, and the future of the peptide industry. What are grey market peptides, and why have they become one of the fastest-growing topics in health, wellness, longevity, and performance? In this episode of Peptides Explained, host John Garrett sits down with Matthew Pac...

In this episode of Peptides Explained , we take a deep dive into KPV , a three-amino-acid peptide derived from alpha-melanocyte stimulating hormone (alpha-MSH) that has generated growing interest for its potential anti-inflammatory effects. We explore the biology behind KPV, how it may influence inflammatory pathways such as NF-kB, and why researchers have studied it in models of ulcerative coliti...

In this episode of Peptides Explained , we take a deep dive into two of the most talked-about Russian research peptides: Selank and Semax . We'll explore where these peptides came from, how they work in the brain, and why researchers have studied them for anxiety, stress resilience, cognitive performance, neuroprotection, and stroke recovery. You'll learn about key mechanisms involving GAB...

In this special episode of Peptides Explained, we're focusing on a topic that affects millions of women but often isn't discussed openly enough: menopause, hormonal signaling, libido, body composition, and the emerging role of peptides. Why does weight gain seem different during menopause? What causes the sudden changes in energy, sleep, skin, hair, and sexual desire? And where do peptides...

GLP-1 medications may affect far more than appetite and weight loss. In this episode, we explore the growing evidence surrounding semaglutide, tirzepatide, and retatrutide and their potential effects on mood, anxiety, dopamine signaling, motivation, and compulsive behavior. We discuss both the research and the real-world patient reports clinicians are increasingly hearing in practice.

Do growth hormone secretagogues increase cancer risk? This episode breaks down the real science behind IGF-1, cancer biology, and compounds like MK-677, Ipamorelin, Sermorelin, CJC-1295, and Tesamorelin. We review: Human IGF-1 cancer studies Acromegaly data Tumor signaling pathways Observational vs causal evidence What current science actually supports This podcast is for informational purposes on...

Does BPC-157 cause cancer — or is that claim being oversimplified? In this episode of Peptides Explained , we take a study-review approach to one of the biggest concerns surrounding BPC-157: its potential angiogenic effects and whether that could theoretically contribute to cancer proliferation. Angiogenesis means new blood vessel formation. It is essential for normal wound healing and tissue repa...

Tesamorelin is one of the few peptides with FDA approval—but its effects on visceral fat and growth hormone signaling have made it a major topic in metabolic health and body composition circles. In this episode of Peptides Explained , we break down: • What tesamorelin actually is • How growth hormone releasing hormone works • Why visceral fat matters metabolically • Clinical trial data and FDA-app...

In this special update episode, I’m announcing a new affiliate partnership between Peptides Explained and Offline Peptides. The mission of this podcast remains unchanged: providing clear, responsible, science-based education around peptides, metabolic health, recovery, and emerging therapeutic research. If you choose to support the show through my affiliate link, I may earn a commission at no addi...

Retatrutide may represent the next evolution in metabolic medicine. In this deep-dive episode of Peptides Explained , we break down the science behind the investigational “triple agonist” peptide that’s generating major attention in obesity and metabolic research. Topics covered: • GLP-1 + GIP + glucagon receptor activation • How retatrutide differs from semaglutide and tirzepatide • Phase 2 clini...

Using the minimal effective dose of GLP-1 medications may be the key to preserving muscle during weight loss. This episode explains how to implement it alongside nutrition and training.

A clinical deep dive into the muscle loss problem on GLP-1 medications. Semaglutide, tirzepatide, and the investigational triple agonist retatrutide all produce remarkable weight loss — but clinical trial data shows that a significant fraction of that loss is lean body mass, not fat. This episode covers the mechanism behind GLP-1-induced muscle wasting, the body composition data from STEP 1 and SU...

Breaking news episode. On April 15, 2026, the FDA formally initiated the reclassification process for BPC-157, TB-500, and other peptides restricted since 2023 — publishing a Federal Register notice and scheduling a July 2026 Pharmacy Compounding Advisory Committee meeting. This episode breaks down the full regulatory timeline, what the Category 1 vs Category 2 framework means, what today's ac...

A clinical breakdown of grey market peptide safety, including contamination risks, testing standards, and how peptide quality impacts biological effects.

GHK-Cu Explained: The Science Behind the Copper Peptide for Skin, Hair, and Healing

A clinical deep dive into BPC-157 covering mechanism, recovery science, dosing patterns, TB-500 synergy, and why it is banned in professional sports.

Are peptides dangerous—or just misunderstood? In this episode of Peptides Explained , we break down the real science behind peptide safety, how these compounds work in the body, and where risk actually exists. You’ll learn: • what peptides are and how they function biologically • the difference between FDA-approved, compounded, and research peptides • what changed with peptide regulation and acces...