Neural Compass

You’ve likely heard that psychiatric progress is often stalled by subjective results. What is less understood is why the field remains slow to adopt in objective measurement even as other medical specialties thrive on hard data. Psychiatry faces a measurement gap. Dr. Arpan Parikh and Dr. Amit Parikh discusses measurement based Care, virtual health, and AI data synthesis. This is their honest acco...

Neuroeconomics, leadership, and brain health are essential for modern performance. Professor Michael Platt from UPenn explains why digital glass creates cognitive exhaustion. You have likely heard that our modern environment is destroying our focus. The scientific reason is that our evolutionary biology clashes with the digital tools we use every day. Professor Platt joins NeuralCompass to provide...

What if healthcare’s biggest AI breakthroughs aren’t about new science—but about finally fixing systems that were never built to scale? In this episode of Neural Compass, Jacob Effron, Managing Director at Redpoint Ventures, joins Jimini’s Mark Jacobstein to explore where AI is already delivering real value in healthcare—and where hype still outpaces reality. Drawing on his experience at Flatiron...

What if the hardest problems in psychology aren’t about data or statistics—but about how we talk, think, and decide what counts as truth? In this episode of Neural Compass, psychologist, writer, and internet favorite Adam Mastroianni joins Jimini’s Mark Jacobstein for a wide-ranging conversation about conversation itself. Drawing from experimental psychology, improv, and lived experience with anxi...

What if fixing mental healthcare isn’t about replacing clinicians—but finally giving them the systems they’ve always lacked? In this episode of Neural Compass, Dr. Harry Ritter, founder and CEO of Alma, joins Jimini’s Mark Jacobstein to explore how technology, insurance alignment, and new business models can unlock better mental health care at scale. Drawing on his experience as a physician, lawye...

Why do some people emerge from trauma resilient, while others carry its effects for decades—or even generations? In this episode of Neural Compass, Harvard neuroscientist and psychiatrist Dr. Nikos Daskalakis joins Jimini’s Mark Jacobstein to unpack the biology of stress and PTSD. Drawing on decades of research spanning animal models, post-mortem human brain studies, and cutting-edge multi-omics,...

What if the answers to mental health, aging, and disease have been encoded inside us all along? In this episode of Neural Compass, geneticist and entrepreneur Dr. Yaniv Erlich joins Jimini’s Mark Jacobstein to explore how data science and molecular biology are converging to reshape precision medicine. Dr. Erlich discusses everything from decoding the human genome to stabilizing RNA for next-genera...

What if the next breakthrough in mental health isn’t a molecule—but a mindset? In this episode of Neural Compass, PsyMed Ventures co-founders Greg Kubin and Matias Serebrinsky join Jimini’s Mark Jacobstein to trace their journey from tech founders to frontier investors betting on the brain. They share how personal experiences with therapy and psychedelics reshaped their view of healing, and why th...

What happens when the tools we build to understand us start to change what it means to be human? In this episode of Neural Compass, Stanford’s Dr. Nick Haber—computer scientist, educator, and co-founder of the Autism Glass Project—joins Jimini’s Mark Jacobstein to explore how AI is entering some of the most human spaces: learning, emotion, and mental health. From wearable devices that help childre...

In this episode of Neural Compass, Mike Kopko—CEO and co-founder of Pearl Health—joins Jimini’s Mark Jacobstein to explore how value-based care, provider enablement, and intelligent incentives could finally help us build the system we deserve. They cover:- Why physicians—not hospitals or payers—are the key to real health care transformation- How value-based care forces a shift from rear-view to wi...

What happens when decades of groundbreaking neuroscience challenge everything we thought we knew about depression? In this episode of Neural Compass, Dr. John Krystal—Chair of Psychiatry at Yale and the scientist whose lab discovered the rapid antidepressant effects of ketamine—joins Jimini’s Mark Jacobstein to explore how novel treatments are reshaping the future of mental health. They cover:- Th...

What does it actually take to deliver high-quality behavioral health care to hundreds of thousands of people? In this episode of Neural Compass, Dr. Stephanie Eken—Chief Medical Officer at Acadia Healthcare—joins Jimini’s Mark Jacobstein to talk about what works (and what still doesn’t) in the real-world mental health system. They cover:- Why navigating care is still so hard—for patients, families...

In this episode of Neural Compass, David Eagleman—Stanford neuroscientist, bestselling author of Livewired, and one of today’s leading communicators of brain science—joins Jimini’s Mark Jacobstein to explore the astonishing adaptability of the human brain and its implications for therapy, technology, and society. They cover:- Why Eagleman calls the brain livewired—not “plastic”—and how it constant...

What happens when a McKinsey alum with a personal history of OCD turns his analytical superpowers toward fixing mental health care? In this episode of Neural Compass, Steve Duke—founder of the Hemingway Group and author of the must-read Hemingway Report—joins Jimini’s Mark Jacobstein for a compelling conversation on the present (and future) of behavioral health. They cover:
- Why the mental health...

In this episode of Neural Compass, Dr. Seth Feuerstein, Founder & CEO of Oui Therapeutics and Yale faculty member, joins Jimini’s Mark Jacobstein for a compelling conversation on why our mental health system overlooks what the data actually says—and what we can do about it. They cover:- A surprising model that redefines how we understand suicidality- Why talk therapy often works—but also often...

What do you get when a leading AI safety innovator, systems thinker, and open-source champion sits down to talk product, philosophy, and the future of LLMs? A conversation that redefines what it means to build responsibly in the age of generative AI.In this episode of Neural Compass, Shreya Rajpal—CEO of Guardrails AI and former self-driving systems engineer—joins Jimini’s Mark Jacobstein to explo...

What happens when a legendary VC-turned-leadership coach brings radical self-inquiry to the startup roller coaster? A conversation that rewrites what it means to lead—with grit, honesty, and a whole lot of heart. In this episode of Neural Compass, Jerry Colonna—CEO of Reboot.io and author of Reboot and Reunion—joins Jimini’s Mark Jacobstein for a powerful reflection on mental health, emotional res...

What happens when a precision health researcher reimagines cancer screening from the ground up—and then builds the AI to make it possible? In this episode of Neural Compass, Dr. Adam Yala, Assistant Professor at UC Berkeley and UCSF, joins Jimini’s Mark Jacobstein for a deep dive into the future of personalized medicine. They cover:- Why traditional cancer screening is too coarse—and how AI can ch...

What if building great AI isn’t just about data and models—but about the mindset of the people behind it? In this episode of Neural Compass, host Mark Jacobstein (co-founder and president of Jimini Health) sits down with Yanda Erlich, a four-time founder, longtime AI investor, and general partner at B Capital. They explore what it means to bet on AI before it’s obvious—and how inner work can shape...

What if the data you collect could actually make mental health care more human? Dr. Amber Childs, Yale psychologist and expert in adolescent mental health, says measurement-based care isn’t just about numbers—it’s about connection. When done right, it strengthens the therapeutic alliance, empowers patients, and helps clinicians catch what they might otherwise miss. In episode five of Neural Compas...

"What if therapy didn’t just happen once a week—but became something you practiced every day?"In this episode of Neural Compass, host Mark Jacobstein (co-founder and president of Jimini Health) sits down with Jon Tippens, a software engineer, musician, and Jimini patient, to explore how technology is reshaping the way we experience mental health care. Jon shares his deeply personal story as one of...

What if anxiety isn’t the problem—but how we respond to it is? In this episode of Neural Compass, host Mark Jacobstein (co-founder and president of Jimini Health) sits down with Dr. Luana Marques, Harvard psychologist and author of Bold Move, to reframe how we think about anxiety, avoidance, and the science of behavioral change. They cover:- Why anxiety isn’t the enemy- Practical tools for breakin...

How does the placebo effect work in the brain and body? The brain can jumpstart your immune system, and science is finally catching up. In our second episode of Neural Compass, we explore one of the most mind-blowing frontiers in health: the connection between belief, biology, and the brain’s role in healing. Host Mark Jacobstein sits down with Dr. Asya Rolls — award-winning neuroscientist and pro...

AI can detect your depression. And we have the data to prove it. In our DEBUT episode of Neural Compass, we're kicking things off with a conversation that gets right to the heart of what this show is about — the intersection of AI, clinical care, and the future of mental and behavioral health. Host Mark Jacobstein sits down with Dr. Lyle Ungar — professor at UPenn and expert in machine learning, p...

Welcome to Neural Compass, a new podcast from Jimini Health. We’re charting the future of mental and behavioral health — at the intersection of AI, psychiatry, neuroscience, and real-world clinical care. Hosted by Jimini’s own Mark Jacobstein, Neural Compass features honest, forward-thinking conversations with the leaders shaping what’s next — from healthcare executives to AI pioneers. Whether you...