MedEvidence Articles

On this week's episode, we look at a disease commonly confused for normal "picky eating," Avoidant/Restrictive Food Intake Disorder . This disorder, which is driven by fear, disgust, sensory sensitivity, and/or a lack of appetite, leads to malnutrition and vitamin deficiency - especially in children. We look at what this disorder is and isn't, variants, some of the possible und...

On this week's episode, we explore the concept to "Food Noise." Food noise is excessive, intrusive, constant thoughts about food that disrupt social, mental, and physical life - including by eating excessive calories. References: Belson, K. NFL games, commercials and the Super Bowl. New York Times [Internet]. 2025 Feb 8 [cited 2026 Jun 23]. Available from: https://www.nytimes.com/20...

In this episode, we’re talking about cochlear synaptopathy, also known as “hidden hearing loss,” a lesser-known form of hearing damage that can make understanding speech difficult even when standard hearing tests appear normal.  References: Ponsot E. Unraveling hidden hearing loss. Elife. 2024 Dec 5;13:e104936. https://doi.org/10.7554/eLife.104936 Haile LM, Kamenov K, Briant PS, Orji AU, Steinmetz...

In this week's episode, we take a first look at early-stage clinical trials for tooth regrowth in Japan. We look at some of the key molecules involved in tooth development, and why they are suppressed after our permanent teeth come in. Finally, we explore what happens when the protein that stops tooth growth is turned off. References Novacescu D, Dumitru CS, Zara F, Raica M, Suciu CS, Barb AC...

On this week's episode, we’re talking about breakthroughs in Type 1 Diabetes management. References: National Park Service. History of wolf management . National Park Service; Accessed 2026, April 30. https://www.nps.gov/yell/learn/historyculture/wolf-management.htm Espona-Noguera A, Ciriza J, Cañibano-Hernández A, Orive G, Hernández RM, Saenz del Burgo L, Pedraz JL. Review of advanced hydrog...

On this week's episode, we look into one of the key benefits of clinical trials: that they tend to isolate against confounding variables. We look at what confounding variables are and look at the long-term example of reported links between sunscreen use and increased skin cancer rates. We look at why excessive sun exposure is dangerous, how sunscreen works, why rates of skin cancer appeared t...

In this episode, we’re talking about the FDA’s push toward real-time clinical trials, and what that could mean for the pace, quality, and oversight of bringing new treatments to patients. References: US Food and Drug Administration. (28 April, 2026). FDA Announces Major Steps to Implement Real-Time Clinical Trials. https://www.fda.gov/news-events/press-announcements/fda-announces-major-steps-imple...

In this episode, we look at the need for cheap, accurate screening tools for common diseases. To that end, we take the example of fatty liver disease. We review the "gold standard" diagnostic tool, liver biopsy, and why that shouldn't be the first line of detection for a fatty liver. We review some standard methods of screening before diving into transient elastography, also known a...

In this week's episode, guest author Maya Yanchuck explores the ins and outs of PCOS. We review what the condition is, symptoms, complications, and what is happening in the body. Finally, we look at treatments, from mental health to medications. References: Azziz R. PCOS: a diagnostic challenge. Reproductive biomedicine online. 2004 Jan 1;8(6):644-8. https://doi.org/10.1016/S1472-6483(10)6164...

In this week's episode, written by guest author Christy Kestner, we explore the neuroscience of misinformation. We look inot what misinformation is, what happens inside the brain when we encounter misinformation, why misinformation can be so hard to correct, and some of the real-life consequences with misinformation - especialyl in relation to health. We close by discussing how we can combat...

In this week's episode, we explore the most common type of degenerative joint disease, osteoarthritis. We look at the risks of getting the disease, complications and symptoms, and what can be done about it. We also look at what may be next on the horizon; clinical trials targeting degenerative joint disease in myriad ways. References: Murphy L, Schwartz TA, Helmick CG, Renner JB, Tudor G, Koc...

In this week's episode, we explore new RNA interference technology and how it is being investigated for clinical research. We look at what high blood pressure is, one of the key underlining systems involved: RAAS, and how current blood pressure medications target this system. We then look at the theory behind RNA interference medicaitons and why they are so exciting for scientists. Refrerence...

In this week's episode, we explore some of the roles receptors play in the body. We focus on Cannabanoid 1 (CB1) receptors, which regulate appetite and energy expenditure in the body, but can have effects in the brain as well. We look at how receptors can do different things depending on location and that the challenge of medications is in targeting right receptors in the right place. Referen...

In this week's episode, we talk about Sjögren's disease, a relatively common autoimmune disease. We explore the risks of contracting the disease, who gets it, symptoms, and complications. We also explore how the disease works on a mechanical level inside the body by hijacking the immune system, and finish by looking at what treatment looks like today and what's coming down the clini...

In this week's episode we explore gene therapies. We look at what genes are, why mutations can be dangerous, and what methods are being investigated to solve these problems. Then we focus on familial hypercholesterolemia as an example and look at what's being researched today to solve this problem. References : Hoekstra M, Van Eck M. Gene editing for the treatment of hypercholesterolemia...

In this week's episode, we explore what happens when the body can't supply enough oxygen to cells. This condition, called anemia, is caused by a drop in red blood cells or the oxygen-carrying hemoglobin inside them. We dive into some of the risks, causes, complications, and treatments associated with anemia. References: Johnson RL, Rubenstein SD. Anemia in the emergency department: evalu...

In this week's episode, we take a look at bipolar disorder. Bipolar disorder is what happens when out-of-control brain chemicals cut our ability to regulate our mood. The condition results in uncontrollable mood swings that can last for weeks at a time, ranging from impuslive mania to debilitating depression. References: Miller S, Dell'Osso B, Ketter TA. The prevalence and burden of bipo...

On this week's episode we investigate the molecule amylin , a hormone that also affects the body and brain. Amylin is released in response to eating, and helps us know when we're full. We look at what amylin is, how it works, and how investigational versions of the hormone may help with obesity and weight loss. References : Lange O, Perez L. Traffic prediction with advanced graph neural...

In this week's episode, we explore the concept of Carbs Last. This is an eating tactic where foods high in fiber and protein are eaten before sugary carbohydrates. A solid history of clinical research studies has shown that this method of eating smooths out spikes in blood glucose and is associated with better outcomes for diabetic patients. Tune in to learn about this fast, free method of he...

In this week's episode, we take a closer look at Neurotrophic Keratopathy (NK), a rare nerve condition affecting the eye. We explore how the eye works, the risks of developing NK, possible complications of the disease, and what is actually happening within the eye. We also dive into current treatments, including an new investigational class of medications being researched. References:  Dua HS...

In this week's episode, we explore hypertriglyceridemia: high triglyceride levels in the blood. We look at what triglycerides are, why they might be elevated, and some of the risks and causes of hypertriglyceridemia. We also look at the pivotal role clinical research has and continues to play in controlling this dangerous condition, and give a powerful look at what's being investigated n...

In this week's episode, we look at the surprising link between mouthwash use and high blood pressure. We explore what mouthwash does, how the bacteria in our mouths are beneficial, and how the products of those bacteria can indirectly affect blood pressure. References: Joshipura K, Muñoz-Torres F, Fernández-Santiago J, Patel RP, Lopez-Candales A. Over-the-counter mouthwash use, nitric oxide a...

This week we explore atopic dermatitis, oftne called eczema. This skin condition is common, long lasting, and can have serious effects on mental health and relationships. We explore who gets it, how it works in the body, and what treatments are available and on the horizon. References: Fisher G. Presentation speech by professor G. Fischer, member of the staff of professors of the Royal Caroline In...

On this week's episode, we show an increased drive into vagus nerve stimulation clinical research. This FDA-approved therapy for major depressive disorder (MDD) is undergoing further trials in an effort to get it approved by big insurance carriers like Medicaid. Hasin DS, Sarvet AL, Meyers JL, et al. Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States...

On this week's episode, we look into the calculations being made to develop new obesity treatments. We go into the history, current best practices, body changes, and some possible new solutions in the weight loss field. References: NIDDK. Overweight & Obesity Statistics. U.S. Department of Health and Human Services.  https://www.niddk.nih.gov/health-information/health-statistics/overweigh...