Listen, Learn, Adapt

This episode does a deep dive into a review paper that explores the diverse health advantages of creatine supplementation specifically for the aging population. Evans C, Pereira F, Candow D, Antonio J. Creatine supplementation as an adjunct to improving healthy aging. Longevity. 2026;6(1):2565997. doi:10.1080/30653495.2025.2565997. Follow Dr. Anthony Novello, PT, DPT @anthonynovello.dpt

This episode does a deep dive into a scientific review by an international panel of experts that systematically addresses and clarifies common misconceptions regarding creatine supplementation . The authors provide evidence-based refutations of myths suggesting that the supplement causes kidney damage, hair loss, or dehydration , asserting its safety for most healthy individuals. Antonio J, Candow...

This episode dissects a systematic review and meta-analysis that evaluates the potential of ketamine as a novel treatment for Post-Traumatic Stress Disorder (PTSD) . Researchers analyzed ten clinical studies involving 363 participants to determine if the drug effectively reduces core symptoms like avoidance and intrusion . Almeida TM, Lacerda da Silva UR, Pires JP, et al. Effectiveness of ketamine...

This episode does a deep dive into a study by Northwestern University researchers who examineed how extended overnight fasting (EOF), specifically ending meals at least three hours before sleep, impacts the health of middle-aged and older adults. Grimaldi D, Reid KJ, Abbott SM, Knutson KL, Zee PC. Sleep-aligned Extended Overnight Fasting Improves Nighttime and Daytime Cardiometabolic Function. Art...

This episode dissects the findings from the DO-HEALTH trial, a large-scale clinical study examining how vitamin D, omega-3, and exercise influence the biological aging of older adults. Bischoff-Ferrari HA, Gängler S, Wieczorek M, et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nature A...

This episode dissects a systematic review and meta-analysis that evaluates the impact of exercise training on five key blood lipid markers to assist in the management of dyslipidemia . Smart NA, Downes D, van der Touw T, et al. The effect of exercise training on blood lipids: a systematic review and meta-analysis. Sports Med . 2025;55:67-78 . doi:10.1007/s40279-024-02115-z Follow Dr. Anthony Novel...

This episode does a deep dive into a 2026 study that investigates whether meat consumption influences cognitive decline and dementia risk based on a person's APOE genetic profile. Norgren J, Carballo-Casla A, Grande G, Börjesson-Hanson A, Xu H, Eriksdotter M, et al. Meat consumption and cognitive health by APOE genotype. JAMA Netw Open. 2026;9(3):e266489. doi:10.1001/jamanetworkopen.2026.6489 Foll...

This episode dissects a systematic review and meta-analysis that investigates how physical activity affects inhibitory control in adults diagnosed with ADHD . Yang Y, Wu CH, Sun L, Zhang TR, Luo J. The impact of physical activity on inhibitory control of adult ADHD: a systematic review and meta-analysis. J Glob Health . 2025;15:04025. Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠...

This episode dissects a study that examines how psychological factors , specifically pain-related fear and catastrophizing , influence recovery in patients with rotator cuff tendinopathy during an 8-week exercise program. Researchers tracked 64 participants to observe if their beliefs about movement and pain changed alongside improvements in shoulder disability . Mears C, Heindel MD, Abeles R, Vil...

This episode dissects a network meta-analysis that evaluates the effectiveness of various non-surgical interventions for children diagnosed with pediatric flexible flatfoot . Researchers categorized treatments into active exercise-based physical therapy , such as neuromuscular electrical stimulation (NMES) and corrective exercises, and passive orthotic interventions , including talus control insol...

This episode does a deep dive into a systematic review that examines the safety of creatine monohydrate supplementation among adolescents and physically active youth . By analyzing five studies published between 2015 and 2025, researchers evaluated the supplement's impact on renal function, liver health, and cardiometabolic markers . Rubinchuk A, Dulkoski Z, Persaud NA, Wallen M. Evaluating th...

This episode dissects a research study that investigates the microbiota-gut-brain axis by comparing coffee drinkers to non-drinkers and observing the effects of caffeine withdrawal and reintroduction . Boscaini S, Bastiaanssen TFS, Moloney GM, Bergamo F, Zeraik L, O’Leary C, et al. Habitual coffee intake shapes the gut microbiome and modifies host physiology and cognition. Nat Commun. Published on...

This episode does a deep dive into an academic perspective that introduces Peakspan , a novel metric defined as the period when an individual maintains at least 90% of their maximum functional capacity in specific physiological or cognitive areas. The authors argue that while humans are living longer, most biological systems—including cardiorespiratory, renal, and immune functions —peak in early a...

This episode does a deep dive into a 2026 study by the MULTI Consortium that identifies a systemic, U-shaped relationship between sleep duration and biological ageing across the human body. By analyzing data from the UK Biobank , researchers utilized 23 biological ageing clocks derived from MRI imaging , plasma proteomics , and metabolomics to show that both insufficient and excessive sleep accele...

This episode dissects a comprehensive systematic review and meta-analysis regarding the recovery of the median nerve after carpal tunnel release surgery . Spanning 199 studies and over 15,000 patients, the research investigates structural and functional healing through metrics like nerve conduction, sensory testing, and grip strength. Sobeeh MG, Elsisy M, Abozaid EM, et al. Neural recovery after c...

This episode examines the potential of creatine monohydrate as a therapeutic tool for managing osteosarcopenia , an age-related decline in both bone density and muscle mass . Candow DG, Kirk B, Chilibeck PD, Duque G. The potential of creatine monohydrate supplementation in the management of osteosarcopenia. Curr Opin Clin Nutr Metab Care. 2025;28(3):235-239. doi:10.1097/MCO.0000000000001118 Follow...

This episode does a deep dive into an academic review that examines the diagnosis and management of cervical facet joint pain resulting from aging or whiplash injuries. Hellinga MD, van Eerd M, Stojanovic MP, et al. 7. Cervical facet pain: degenerative alterations and whiplash-associated disorder. Pain Pract. 2025;25(2):e70005. doi:10.1111/papr.70005 Follow Dr. Anthony Novello, PT, DPT ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠...

This episode dissects a meta-analysis and systematic review that examines the clinical impact of early exercise versus brace immobilization for patients recovering from arthroscopic rotator cuff repair. Hao BR, Li HQ, Liang A. Effects of early exercise and immobilization after arthroscopic rotator cuff repair surgery: a systematic review and meta-analysis of randomized controlled trials. BMC Muscu...

This episode dissects a study that investigates whether vitamin D levels in early midlife are linked to early brain indicators of dementia. Researchers analyzed data from the Framingham Heart Study , tracking participants for over 16 years to compare their initial blood samples with later PET scans . Mulligan MD, Scott MR, Yang Q, Wang R, Ghosh S, Johnson KA, et al. Association of circulating vita...

This episode does a deep dive into a systematic review and meta-analysis evaluating the impact of multidisciplinary interventions that incorporate exercise to treat non-specific chronic low back pain . By analyzing 31 studies published between 1998 and 2021, the authors sought to determine if combined therapies effectively improve health outcomes across various global regions. Vega-Retuerta N, Sán...

This episode dissects a systematic review and meta-analysis that evaluates how CrossFit training impacts adults who are overweight or obese . Blanco-Martínez N, González-Devesa D, Sanchez-Lastra MA, Diz-Gómez JC, Ayán-Pérez C. The effects of CrossFit® training in adults with obese or overweight: a systematic review of randomized controlled trials. Med Fam SEMERGEN. 2025;51:102512. doi:10.1016/j.se...

This episode does a deep dive into the 2025 EULAR updated recommendations for integrating physical activity and reducing sedentary behavior in the care of patients with inflammatory arthritis and osteoarthritis . Rausch Osthoff AK, Vliet Vlieland TPM, Ferreira RJO, Amarnani R, Battista S, Orlinov D, et al. EULAR recommendations for physical activity in people with inflammatory arthritis and osteoa...

This episode dissects a research article that investigates how long-term aerobic exercise influences various biological markers associated with cardiovascular disease (CVD) risk and psychological stress. Researchers conducted a year-long clinical trial with middle-aged adults, comparing a 150-minute weekly exercise regimen against a control group receiving only health information. The study measur...

This episode dissects a systematic review and meta-analysis evaluating various preventative treatments for vestibular migraine (VM), a condition characterized by episodic vertigo and headaches. By analyzing 13 clinical studies, the authors examined the efficacy of pharmacologic agents—such as beta-blockers, calcium channel blockers, and antidepressants—alongside vestibular rehabilitation and dieta...

This episode does a deep dive into a systematic review that synthesizes qualitative research to explore the lived experiences of individuals suffering from lower limb tendinopathy . The researchers identified ten core themes. Hopes M, Stubbs P, Grimaldi A, Nasser A. Lived experiences of people with lower limb tendinopathy – a systematic review with qualitative evidence synthesis. J Orthop Sports P...