JCO Precision Oncology Conversations

In this JCO PO Article Insights episode, host Carolyn Lineen summarizes the article, " Genomics of MTAP Loss in >500,000 Solid Tumor Specimens Profiled Using Comprehensive Genomic Profiling Platforms " by Dean C. Pavlick and colleagues. LINK TO FULL TRANSCRIPT

JCO PO authors Dr. Matthew Campbell and Dr. Mohammad Moussa at The University of Texas MD Anderson Cancer Center and Baylor College of Medicine, Houston, Texas, share insights into their article, " Efficacy of Immune Checkpoint Blockade in Advanced Upper Tract Urothelial Cancer With DNA Mismatch Repair Deficiency or Microsatellite Instability. " Host Dr. Rafeh Naqash and Drs. Campbell and Moussa d...

In this JCO PO Article Insights episode, host Jordan Goldstein summarizes the article, " EXONERATE-TRaCE: A Liquid Biopsy for Tracking Response to Anti–Epidermal Growth Factor Receptor–Based Therapy in Metastatic Colorectal Cancer " byTakahashi,  et al. LINK TO FULL TRANSCRIPT

JCO PO author Dr. Tejas Patil at University of Colorado Cancer Center shares insights into the JCO PO article, " CRESTONE: A Phase II Study of the Efficacy and Safety of the HER3 Monoclonal Antibody, Seribantumab, in Solid Tumors With Neuregulin-1 (NRG1) Fusions ". Host Dr. Rafeh Naqash and Dr. Patil discuss the anti-tumor activity and safety data of seribantumab from the CRESTONE study (NCT043832...

In this JCO PO Article Insights episode, host Carolyn Lineen summarizes the article, " Prognostic Significance of Blood-Based Multicancer Detection in Circulating Tumor DNA: Five-Year Outcomes Analysis " bySwanton et al. LINK TO FULL TRANSCRIPT

In this JCO PO Article Insights episode, host Jordan Goldstein summarizes the article, "Generic Protocols for Analytical Validation of Tumor-Informed Circulating Tumor DNA Assays for Molecular Residual Disease: The Blood Profiling Atlas in Cancer's Molecular Residual Disease Analytical Validation Working Group Consensus Recommendation" by Baden et al. TRANSCRIPT Jordan Goldstein: Hello, and welcom...

In this JCO Precision Oncology Article Insights episode, host Dr. Carolyn Lineen summaries the article, " Concordance of Oncotype DX Breast Recurrence Score Assay Results Between Paired Core Needle Biopsy and Surgical Excision Specimens in Hormone Receptor Positive, HER2-Negative Early-Stage Breast Cancer ," by Nassar et al. TRANSCRIPT Carolyn Lineen: Hello and welcome to JCO Precision Oncology Ar...

JCO PO author Dr. Foldi at UPMC Hillman Cancer Center and University of Pittsburgh School of Medicine shares insights into the JCO PO article, " Personalized Circulating Tumor DNA Testing for Detection of Progression and Treatment Response Monitoring in Patients With Metastatic Invasive Lobular Carcinoma of the Breast. " Host Dr. Rafeh Naqash and Dr. Foldi discuss how serial ctDNA testing in patie...

In this JCO Precision Oncology Article Insights episode, host Dr. Jiasen He summaries the article, " Longitudinal Evaluation of Circulating Tumor DNA as a Prognostic Biomarker to Detect Molecular Residual Disease in Germ Cell Tumors ," by Hassoun et al. TRANSCRIPT Jiasen He : Hello, and welcome to the JCO Precision Oncology Article Insights . I'm your host, Jiasen He, and today, we'll be discussin...

JCO PO author Dr. Wainberg at UCLA shares insights into the JCO PO article, "Prevalence of FGFR2b Protein Overexpression in Advanced Gastric Cancers During Prescreening for the Phase III FORTITUDE-101 Trial." Host Dr. Rafeh Naqash and Dr. Wainberg discuss how FGFR2b prevalence was similar across geographic regions and within defined patient and sample variables regardless of the level of expressio...

In this JCO Precision Oncology Article Insights episode, host Dr. Harold Nathan Tan summarizes " Palbociclib in Patients With Head and Neck Cancer and Other Tumors With CDKN2A Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study " by Worden et al.  TRANSCRIPT Harold Nathan Tan : Welcome to JCO Precision Oncology Article Insights , where we explore research that is...

JCO PO author Dr. Shilpa Gupta at Cleveland Clinic Children's Hospital shares insights into her article, " Fibroblast Growth Factor Receptor 3 (FGFR3) Alteration Status and Outcomes on Immune Checkpoint Inhibitors (ICPI) in Patients with Metastatic Urothelial Carcinoma ". Host Dr. Rafeh Naqash and Dr. Gupta discuss how FGFR3 combined with TMB emerged as a biomarker that may be predictive for respo...

In this JCO Precision Oncology Article Insights episode, Natalie DelRocco summarizes " Genomic Risk Classifiers in Localized Prostate Cancer: Precise but Not Standardized " by Góes et al. published on September 10, 2025. TRANSCRIPT Natalie DelRocco: Hello and welcome to JCO Precision Oncology Article Insights . I'm your host, Natalie DelRocco, and today we will be discussing the editorial " Genomi...

Authors Drs. Jessica Ross and Alissa Cooper share insights into their JCO PO article, " Clinical and Pathologic Landscapes of Delta-Like Ligand 3 and Seizure-Related Homolog Protein 6 Expression in Neuroendocrine Carcinomas "  Host Dr. Rafeh Naqash and Drs. Ross and Cooper discuss the landscape of Delta-like ligand 3 (DLL3) and seizure-related homolog protein 6 (SEZ6) across NECs from eight differ...

In this episode of JCO PO Article Insights, host Dr. Jiasen He summarizes the article, " Somatic Mutation Profiles of Colorectal Cancer by Birth Cohort " by Gilad, et al published October 11, 2025. TRANSCRIPT Jiasen He: Hello, and welcome to the JCO Precision Oncology Article Insights . I am your host, Jiasen He, and today, we will be discussing the JCO Precision Oncology article, " Somatic Mutati...

JCO PO author Dr. Bryson Katona at the University of Pennsylvania Perelman School of Medicine shares insights into his article, " Areas of Uncertainty in Pancreatic Cancer Surveillance: A Survey Across the International Pancreatic Cancer Early Detection (PRECEDE) Consortium " Host Dr. Rafeh Naqash and Dr. Katona discuss how, given differing guidelines as well as lack of detail about how PC surveil...

JCO PO author Dr. Asaf Maoz at Dana-Farber Cancer Institute shares insights into article, " Causes of Death Among Individuals with Lynch Syndrome in the Immunotherapy Era ." Host Dr. Rafeh Naqash and Dr. Maoz discuss the causes of death in individuals with LS and the evolving role of immunotherapy. TRANSCRIPT Dr. Rafeh Naqash: Hello, and welcome to JCO Precision Oncology Conversations , where we b...

In this JCO Precision Oncology Article Insights episode, Dr. Jiasen He summarizes JCO PO article " Synthetic Lethal Co-Mutations in DNA Damage Response Pathways Predict Response to Immunotherapy in Pan-Cancer " by Hua Zhong et al. TRANSCRIPT Jiasen He: Hello and welcome to the JCO Precision Oncology Article Insights . I am your host, Jiasen He, and today we will be discussing the JCO Precision Onc...

JCO PO authors Dr. Abhishek Tripathi and Dr. Salvador Jaime-Casas at City of Hope Comprehensive Cancer Center share insights into their article, " Comparative Genomic Characterization of Small Cell Carcinoma of the Bladder Compared With Urothelial Carcinoma and Small Cell Lung Carcinoma ."  Host Dr. Rafeh Naqash and Drs. Tripathi and Jaime-Casas discuss a novel understanding of the genomic alterat...

In this JCO PO Article insights episode, Dr. Jiasen He summarized the JCO PO article " Mucin 16–Directed Therapy in Pediatric Sarcomas: Case Evidence of Ubamatamab Efficacy in Epithelioid Sarcoma and Its Implications for Other Sarcoma Subtypes " by Connolly et al. TRANSCRIPT Jiasen He: Hello, and welcome to JCO Precision Oncology Article Insights . I'm your host, Jiasen He, and today we'll be disc...

JCO PO author Dr. Alison M. Schram at Memorial Sloan Kettering Cancer Center shares insights into her JCO PO article, " Retrospective Analysis of BRCA-Altered Uterine Sarcoma Treated With Poly(ADP-ribose) Polymerase Inhibitors ." Host Dr. Rafeh Naqash and Dr. Schram discuss relevant genomic and clinical features of patients with BRCA-altered uterine sarcoma and the efficacy of PARPis in this popul...

In this JCO Precision Oncology Article Insights episode, Natalie DelRocco summarizes " Prognostic Value of the G2 Expression Signature and MYC Overexpression in Childhood High-Grade Osteosarcoma " by Roelof van Ewijk et al. published on May 29, 2025. TRANSCRIPT Natalie Del Rocco: Hello, and welcome to JCO Precision Oncology Article Insights . I'm your host, Natalie DelRocco, and today we will be d...

In this JCO Precision Oncology Article Insights episode, Natalie DelRocco summarizes " Prognostic Value of the G2 Expression Signature and MYC Overexpression in Childhood High-Grade Osteosarcoma " by Roelof van Ewijk et al. published on May 29, 2025. TRANSCRIPT Natalie Del Rocco: Hello, and welcome to JCO Precision Oncology Article Insights . I'm your host, Natalie DelRocco, and today we will be d...

In this JCO Precision Oncology Article Insights episode, Natalie DelRocco summarizes " Real-Time Monitoring in Renal Cell Carcinoma With Circulating Tumor DNA: A Step Forward, but How Far? " by Zeynep B. Zengin et al. published on February 28, 2025. TRANSCRIPT The guest on this podcast episode has no disclosures to declare. Natalie DelRocco: Hello, and welcome to JCO Precision Oncology Article Ins...

JCO PO author Dr. Philip Philip at Henry Ford Cancer Institute and Wayne State University shares insights into his JCO PO article, " Incorporating Circulating Tumor DNA Testing Into Clinical Trials: A Position Paper by the National Cancer Institute GI Oncology Circulating Tumor DNA Working Group ." Host Dr. Rafeh Naqash and Dr. Philip discuss how prospective trials are required to clarify the role...