JCO Precision Oncology Conversations

In this JCO Precision Oncology Article Insights episode, Jiasen He summarizes "Predictive Impact of Tumor Mutational Burden on Real-World Outcomes of First-Line Immune Checkpoint Inhibition in Metastatic Melanoma" by Dr. Miles C. Andrews, et al. published on June 07, 2024. Transcript The guest on this podcast episode has no disclosures to declare. Jiasen He: Hello and welcome to the JCO Precision...

JCO PO author Dr. Dean A. Regier at the Academy of Translational Medicine, University of British Columbia (UBC), and the School of Population and Public Health, BC Cancer Research Institute shares insights into his JCO PO article, "Clinical Effectiveness and Cost-Effectiveness of Multigene Panel Sequencing in Advanced Melanoma: A Population-Level Real-World Target Trial Emulation." Host Dr. Rafeh...

In this JCO PO Article Insights episode, host Harold Tan summarizes Low Kynurenine Levels Among Exceptional Responders on Phase Ib Trial of the HDAC Inhibitor Abexinostat with Pazopanib by Tsang et al, published November 07, 2024. Transcript Harold Nathan Tan: Welcome to JCO Precision Oncology Article Insights , where we explore cutting-edge discoveries in the world of cancer treatment and researc...

JCO PO author Dr. Timothy Showalter at Artera and University of Virginia shares insights into his JCO PO article, " Digital Pathology–Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer " . Host Dr. Rafeh Naqash and Dr. Showalter discuss how multimodal AI as a prognostic marker in nonmetastatic...

In this JCO Precision Oncology Article Insights episode, Natalie DelRocco summarizes " Digital Pathology–Based Multimodal Artificial Intelligence Scores and Outcomes in a Randomized Phase III Trial in Men With Nonmetastatic Castration-Resistant Prostate Cancer " by Felix Y. Feng, et al published January 31, 2025. Come back for the next episode where JCO Precision Oncology Conversations host, Dr. R...

In this JCO Precision Oncology Article Insights episode, Jiasen He summarizes " Midline Low-Grade Gliomas of Early Childhood: Focus on Targeted Therapies. " by Dr. Ludmila Papusha et al. published on July 08, 2024. TRANSCRIPT   Jiasen He: Hello and welcome to JCO Precision Oncology Article Insights . I'm your host Jiasen He, a JCO Journal' s Editorial Fellow. Today, I will provide a summary on " M...

JCO PO author Dr. Hatim Husain at University of California San Diego, shares insights into his JCO PO article, "A dagrasib Treatment After Sotorasib-Related Hepatotoxicity in Patients With KRASG12C-Mutated Non–Small Cell Lung Cancer: A Case Series and Literature Review ", one of the top downloaded articles of 2024. Host Dr. Rafeh Naqash and Dr. Husain discuss how to utilize real-world and clinical...

In this JCO PO Article Insights episode, Harold Nathan Tan summarizes findings from the JCO PO article, " Circulating Tumor DNA as a Prognostic Biomarker for Recurrence in Patients With Locoregional Esophagogastric Cancers With a Pathologic Complete Response ." TRANSCRIPT Harold Nathan Tan: Welcome to JCO Precision Oncology Article Insights where we explore cutting-edge discoveries in the world of...

JCO PO author Dr. David R. Gandara at UC Davis Comprehensive Cancer Center, shares insights into his JCO PO article, " Plasma Proteome–Based Test for First-Line Treatment Selection in Metastatic Non–Small Cell Lung Cancer ," one of the Top Articles of 2024. Host Dr. Rafeh Naqash and Dr. Gandara discuss how the PROphet® blood test supports first-line immunotherapy treatment decisions for metastatic...

JCO PO authors Dr. Philippe Bedard (Staff Medical Oncologist at Princess Margaret Cancer Centre and Professor of Medicine at University of Toronto) and Dr. Alberto Hernando Calvo (Medical Oncologist at Vall d´Hebron University Hospital) share insights into their JCO PO article, " Combined Transcriptome and Circulating Tumor DNA Longitudinal Biomarker Analysis Associates With Clinical Outcomes in A...

In this JCO Precision Oncology Article Insights episode, Miki Horiguchi summarizes two articles: " Germline Susceptibility to Renal Cell Carcinoma and Implications for Genetic Screening , " by Dr. Kate I. Glennon et al. published on August 01, 2024, and " Incidental Pathogenic Variants in Renal Cell and Urothelial Carcinoma: Is It Time for Universal Screening? " by Dr. Salvador Jaime-Casas, et al....

JCO PO author Dr. Michael J. Hall, Professor of Medicine, Chairman of the Department of Clinical Genetics, and Co-Leader of the Cancer Prevention and Control Program at Fox Chase Cancer Center in Philadelphia, PA, shares insights into the JCO PO article, " Uptake of Aspirin Chemoprevention in Patients with Lynch Syndrome ." Host Dr. Rafeh Naqash and Dr. Hall discuss the finding that only about 1 i...

In this JCO Precision Oncology Article Insights episode, Mitchell Elliot summarizes the article " Talazoparib in Patients With Solid Tumors With BRCA1/2 Mutation: Results From the Targeted Agent and Profiling Utilization Registry Study " by Dr. Jordan Srkalovic et al.  published on June 12th, 2024. TRANSCRIPT Mitchell Elliott: Hello, welcome to JCO Precision Oncology Article Insights . I'm your ho...

JCO PO author Dr. Amar U. Kishan, Professor, Executive Vice Chair, and Chief of Genitourinary Oncology Service in the Department of Radiation Oncology at the University of California, Los Angeles, shares insights into his JCO PO article, " Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomogr...

In this JCO Precision Oncology Article Insights episode, Mitchell Elliot summarizes an editorial: " A Targeted Methylation–Based Multicancer Early Detection Blood Test Preferentially Detects High-Grade Prostate Cancer While Minimizing Overdiagnosis of Indolent Disease " by Dr. Brandon A. Mahal, et al. published on August 29, 2024.   TRANSCRIPT Mitchell Elliott: Hello and welcome to JCO Precision O...

JCO PO author Dr. Alok A. Khorana, MD, FASCO, Professor of Medicine, Cleveland Clinic and Case Comprehensive Cancer Center, shares insights into the JCO PO article, " Molecular Differences With Therapeutic Implications in Early-Onset Compared With Average-Onset Biliary Tract Cancers ." Host Dr. Rafeh Naqash and Dr. Khorana discuss how multiomic analysis shows higher FGFR2 fusions and immunotherapy...

In this JCO Precision Oncology Article Insights episode, Miki Horiguchi summarizes an editorial: " Expanding the Reach of Personalized Medicine in Cancer Care: Current Progress and Future Directions of JCO Precision Oncology " by Dr. Yushu Shi et al. published on May 30, 2024. TRANSCRIPT Hello and welcome to  JCO Precision Oncology Article Insights . I'm your host Miki Horiguchi, an ASCO Journals...

JCO PO author Dr. Jonathan D. Tward, M.D., Ph. D., FASTRO, at the HCI Genitourinary Cancers Center and the Huntsman Cancer Institute at the University of Utah, shares insights into his JCO PO article, " Using the Cell-Cycle Risk Score to Predict the Benefit of Androgen-Deprivation Therapy Added to Radiation Therapy in Patients With Newly Diagnosed Prostate Cancer. " Host Dr. Rafeh Naqash and Dr. T...

In this JCO Precision Oncology Article Insights episode, Miki Horiguchi summarizes two articles: " Biomarker-Driven Oncology Trial Design and Subgroup Characterization: Challenges and Potential Solutions " by Wang, et al. published on June 7, 2024, and " Biomarkers in Oncology: Complexities in Biomarker-Driven Studies and Statistical Analysis " by Uno, et al. published on July 22, 2024. TRANSCRIPT...

In this JCO Precision Oncology Article Insights episode, Fergus Keane provides a summary on " Multi-Institutional Study Evaluating the Role of Circulating Tumor DNA in the Management of Appendiceal Cancers " by Belmont, et al published on May 9th, 2024. TRANSCRIPT  Fergus Keane: Hello and welcome to JCO Precision Oncology Article Insights . I'm your host, Fergus Keane, an ASCO editorial fellow. To...

JCO PO author Dr. Samuel J. Klempner shares insights into his JCO PO article, "PD-L1 Immunohistochemistry in Gastric Cancer: Comparison of Combined Positive Score and Tumor Area Positivity across 28-8, 22C3, and SP263 assays". Host Dr. Rafeh Naqash and Dr. Klempner discuss assessing the analytical comparability of three commercially available PD-L1 assays and two scoring algorithms used to assess...

In this JCO Precision Oncology Article Insights episode, Mitchell Elliot provides a summary on " Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer " by Shaw, et al published on May 1st, 2024. TRANSCRIPT The guest on this podcast episode has no disclosures to declare.  Mitchell Elliott: Hello and welcome to th...

JCO PO author Dr. Jun Gong shares insights into his JCO PO articles, " Phase II Study of Erdafitinib in Patients with Tumors with FGFR Amplifications: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Sub-protocol K1 " and " Phase II Study of Erdafitinib in Patients with Tumors with FGFR Mutations or Fusions: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Sub-protocol K2 ". Host Dr. Rafeh...

In this JCO PO Article Insights episode, Miki Horiguchi provides a summary on the article, " TARGET: A Randomized, Noninferiority Trial of a Pretest, Patient-Driven Genetic Education Webtool Versus Genetic Counseling for Prostate Cancer Germline Testing and explains what a non-inferiority trial is.  TRANSCRIPT Miki Horiguchi:  Hello and welcome to JCO Precision Oncology Article Insights . I'm your...

JCO PO author Dr. Christian Rolfo shares insights into his JCO PO article, " Liquid Biopsy of Lung Cancer Before Pathological Diagnosis Is Associated With Shorter Time to Treatment ." Host Dr. Rafeh Naqash and Dr. Rolfo discuss how early liquid biopsy in aNSCLC in parallel with path dx is associated with shorter time to treatment. TRANSCRIPT   Dr. Rafeh Naqash: Hello and welcome to JCO Precision O...