JAMA Clinical Reviews

Polycystic kidney disease is the most common genetic kidney disease worldwide and is characterized by progressive development of kidney cysts. Author Nerra Dahl, MD, PhD, Mayo Clinic, discusses the pathophysiology, clinical presentation, diagnosis, prognosis, and treatment of ADPKD in adults, with JAMA Associate Editor David Simel, MD, MHS. Related Content: Autosomal Dominant Polycystic Kidney Dis...

Chronic myeloid leukemia is a myeloproliferative neoplasm that affects approximately 5 million people worldwide. Tyrosine kinase inhibitors, such as imatinib, have substantially improved survival in patients with chronic myeloid leukemia. In this podcast, author Elias J. Jabbour, MD, of the University of Texas MD Anderson Cancer Center, discusses diagnosis and treatment of chronic myeloid leukemia...

Interview with Tumaini Rucker Coker, MD, MBA, USPSTF member and coauthor of Screening for Food Insecurity: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Preventive Services for Food Insecurity Food Insecurity, Health, and Health Care in the US Navigating the Complexity of Food Insecurity Screening...

Prostate cancer is the most common nonskin cancer in men in the US and the second most common cancer in men worldwide. Author R. Bruce Montgomery, MD, of the University of Washington joins JAMA Senior Editor Karen Lasser, MD, MPH, to discuss the current evidence regarding the epidemiology, diagnosis, and management of localized and metastatic prostate cancer. Related Content: Prostate Cancer

A recent JAMA article reviews the 3 most common eating disorders, their risk factors, diagnosis and treatment. In this podcast, coauthors Evelyn Attia, MD, and Timothy Walsh, MD, both from Columbia University Irving Medical Center, discuss eating disorders with JAMA Deputy Editor Kristin Walter, MD, MS. Related Content: Eating Disorders

In 2024, the American Law Institute revised the legal standard for assessing medical negligence. Author Christopher T. Robertson, JD, PhD, of Boston University School of Law joins JAMA Executive Editor Gregory Curfman, MD, to discuss these changes in the first-ever restatement of the law. Related Content: A New Legal Standard for Medical Malpractice Another Medical Malpractice Crisis?

Out-of-hospital cardiac arrest in apparently healthy adults younger than 40 years ranges from 4 to 14 per 100 000 person-years worldwide. Among young adults who have had cardiac arrest outside of a hospital, only 9% to 16% survive to hospital discharge. Author Zian Tseng, MD, MAS, University of California, San Francisco, discusses this and more with JAMA Associate Editor David L. Simel, MD, MHS. R...

Guidelines from the American Thoracic Society report on the value of pulmonary rehabilitation for people with COPD, interstitial lung disease, or pulmonary hypertension. JAMA Clinical Guidelines Synopsis author Michaela R. Anderson, University of Pennsylvania, discusses these guidelines and more with JAMA Associate Editor David Simel, MD, MHS. Related Content: Pulmonary Rehabilitation for Adults W...

Essential thrombocythemia, a clonal myeloproliferative neoplasm with excessive platelet production, is associated with an increased risk of thrombosis and bleeding. Author Ayalew Tefferi, MD, of the Mayo Clinic, joins JAMA Associate Editor David Simel, MD, MHS, to discuss diagnosis and treatment of this condition. Related Content: Essential Thrombocythemia

Interview with Esa M. Davis, MD, MPH, USPSTF member and coauthor of Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Osteoporosis to Prevent Fractures Screening for Osteoporosis to Prevent Fractures Fracture Risk Assessment as a Component...

NIH'S policies, programs, and research funding fill gaps in knowledge about women's health. Janine Austin Clayton, MD, of the NIH joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss key programs, policies, and scientific advances of the NIH that have informed and improved women's health. Related Content: Recent Developments in Women's Health Research at the US National Ins...

JAMA Deputy Editor Mary McDermott, MD, and JAMA Deputy Editor Kristin Walter, MD, MS, highlight their selections of top JAMA 2024 Clinical Reviews podcasts. Related Content: Dialysis for Chronic Kidney Failure (podcast) Diagnosis and Treatment of Community-Acquired Pneumonia (CAP) (podcast) Obesity Medications (podcast) Dialysis for Chronic Kidney Failure Community-Acquired Pneumonia Medications f...

Chronic kidney disease develops among 30% to 40% of people with type 1 or type 2 diabetes during their lifetime. Author Ian H. de Boer, MD, MS, of the University of Washington Division of Nephrology, discusses the evaluation and treatment of chronic kidney disease in patients with type 1 and type 2 diabetes with JAMA Senior Editor Karen Lasser, MD, MPH. Related Content: Diabetes and Chronic Kidney...

The number of people living with atrial fibrillation (AF) is increasing, and they have a higher rate of cardiovascular events, chronic kidney disease, and dementia compared with people without AF. Emelia J. Benjamin, MD, ScM, an epidemiologist and cardiologist, discusses current diagnosis and treatment of AF with JAMA Deputy Editor Mary McGrae McDermott, MD. Related Content: Atrial Fibrillation

Allogeneic stem cell transplantation is a potentially life-saving therapy for some patients with hematologic and bone marrow cancers and certain nonmalignant conditions such as sickle cell disease. Hermioni L. Amonoo, MD, MPP, MPH, of Harvard Medical School and Dana-Farber Cancer Institute, joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the process of allogeneic stem cell donation. Re...

JAMA Senior Editor Derek Angus, MD, MPH, and JAMA Associate Editor Christopher Seymour, MD, MSc, discuss 4 critical care trials published in JAMA and simultaneously presented at the 2024 CCR Down Under meeting in Melbourne, Australia, with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Electronic Sepsis Screening Among Patients Admitted to Hospital Wards Early Restric...

Access to obstetric care in US hospitals has been declining, while maternal mortality is on the rise. A new research letter published in JAMA quantifies losses and gains of obstetric care at rural and urban short-term acute care hospitals in the US between 2010-2022. Author Katy Kozhimannil, PhD, MPA, discusses this and more with JAMA Deputy Editor Linda Brubaker, MD, MS. Related Content: Obstetri...

Ovarian aging is an important cause of infertility in women older than 35 years. Success rates of fertility treatment decline with age, most commonly due to declining ovarian function. Author Albert L. Hsu, MD, MS, of University of Cincinnati, Ohio, discusses this and more with JAMA Deputy Editor Kristin L. Walter, MD, MS. Related Content: Ovarian Aging and Fertility

Mpox is an evolving global health threat, and clinicians should be aware of characteristic signs and symptoms to ensure timely diagnosis and appropriate management. Author Jason Zucker, MD, MS, of Columbia University Irving Medical Center speaks with JAMA Deputy Editor Preeti Malani, MD, MSJ, about the transmission, diagnosis, management, and prevention of mpox. Related Content: Mpox Clinical Pres...

Calcific aortic stenosis affects approximately 12% of people >75 years in the US and worldwide leads to more than 100 000 deaths each year. Catherine M. Otto, MD, PhD, of the University of Washington School of Medicine, Seattle, discusses the symptoms, diagnosis, and treatment of aortic stenosis with JAMA Deputy Editor Kristin L. Walter, MD, MS. Related Content: Calcific Aortic Stenosis

CAR T cells are genetically engineered to express a receptor that recognizes and kills tumor cells. CAR T-cell products are now FDA approved for 6 hematologic malignancies. Author Jennifer N. Brudno, MD, National Cancer Institute, joins JAMA Deputy Editor Mary McGrae McDermott, MD, to discuss "CAR T Cells and T-Cell Therapies for Cancer: A Translational Science Review." Related Content: CAR T Cell...

Peptic ulcer disease affects approximately 1% of the population in the US, and H pylori is a common cause of peptic ulcer disease. Author Nimish Vakil, MD, a gastroenterologist from the University of Wisconsin, Madison, discusses current evidence regarding diagnosis and treatment of peptic ulcer disease with JAMA Deputy Editor Mary McGrae McDermott, MD. Related Content: Peptic Ulcer Disease

High prescription costs are a major barrier to the optimal treatment of many health conditions. Prescribers need tools to help patients find the lowest drug costs. Author Hussain S. Lalani, MD, MPH, MSc, of Brigham and Women's Hospital and Harvard Medical School joins JAMA Senior Editor Anne R. Cappola, MD, ScM, to discuss "Strategies to Help Patients Navigate High Prescription Drug Costs." Relate...

Even though highly effective medications are currently available to prevent HIV, there are about 1.3 million new infections worldwide each year. Monica Gandhi, MD, MPH, of the University of California San Francisco joins JAMA Senior Editor Karen E. Lasser, MD, MPH, to discuss preexposure prophylaxis (PrEP) for HIV. Related Content: Preexposure Prophylaxis (PrEP) for HIV What Is Doxycycline Postexp...

In July 2023, the US Food and Drug Administration (FDA) approved Opill, a daily progestin-only oral contraceptive for over-the-counter sale to people of all ages. Daniel Grossman, MD, discusses this and more with JAMA Associate Editor Melissa A. Simon, MD, MPH. Related Content: Over-the-Counter Oral Contraceptives Over-the-Counter Oral Contraceptive Pills Over-the-Counter Progestin-Only Oral Contr...