ID:IOTS - Infectious Disease Insight Of Two Specialists

WAAW! This week, to celebrate World AMR Awareness Week, Callum is Joined by Andrew, Fran, Jo and Simon from the Scottish Antimicrobial Prescribing Group. Listen in to hear all about SAPG and their important work, plus we discuss WAAW and what you can do to help tackle AMR. Show notes for this episode here , including links to the resources mentioned. Sign up to be an #antibioticguardian here . Sup...

Have you ever looked at your microbiology lab report and wondered "What does resistant mean anyway?"  We're sure you have (and if you haven't you should have)! And conveniently we've recorded this podcast episode to explain how it all works! We talk through the definition of S, I & R, plus some explanation on the science behind these letters. This is the first in the n...

They're new, they're weird, and we don't use them very much (or at all), but that won't stop your favourite ID:IOTS sounding off on these novel tetracyclines! In this episode we discuss: An overview of the 3 drugs, including spectrum & penetrance; pharmacokinetics; EUCAST breakpoints; resistance mechanisms; and the recommendations for use in the IDSA DTR Gram Negative guide...

In which Jame talks about the rationale for IVOS, evidence base for the pros and cons, and then finishes by giving the UK oral switch criteria an absolute rinsing. Prep notes available here .  Support the show Support us on:  Patreon:  https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee:  https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes ha...

Moraxella means more moronic puns from Jame&Callum. A short episode for some short rods. Listen to hear about this coccobacillus, how to identify it in the lab and what sort of clinical syndromes it causes. Show note for this episode here Support the show Support us on:  Patreon:  https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee:  https://www.buymeacoffee.com/idiotspod Prep notes for complet...

Join Jame and Callum as they discuss this paper which examines where these new antibiotics are going, and why they aren't widely available. Notes for this episode here Support the show Support us on:  Patreon:  https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee:  https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episodes have prep notes). If y...

Join Jame and Callum on this episode about the  ultimate 4 rings of power: Tetracyclines. The swiss army knife of antibiotics. We talk through the history, uses, mechanism, PK/PD and resistance. Become a pharmacophile as you learn something about pharmacophores. Shows notes for this episode here Support the show Support us on:  Patreon:  https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee:  https:/...

Jame and Callum are joined by Lee John and Ella for this episode around the arch-villain of atypical pneumonia and the bogeyman of every spa. Yes Legionella pneumophila (and friends) are addressed in depth whilst this podcast is aerosolised around the world. Show notes for this episode here Support the show Support us on:  Patreon:  https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee:  https://www....

You'll be whooping with knowledge after listening to this one. Come hear all about Bordetella species. From pertussis to kennel cough you'll hear it all. Show notes for this episode here Support the show Support us on:  Patreon:  https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee:  https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be found here (Not all episode...

The Spring Meeting of the British Infection Assocation is a must for UK infection trainees; In this week's episode Callum summarises for Jame (who was there, but didn't take any notes) the main learning points from the meeting. Show notes for this episode here BIA membership is FREE to UK infection trainees, reasonably priced for everyone else, and paid memberships come with online acces...

Jame was there but Callum wasn't! The British Society for Antimicrobial Chemotherapy have several conferences throughout the year, including a Spring meeting with their AGM. But what topics were discussed, I hear you wonder? WELL WONDER NO MORE: Jame'll take you through it! Notes for this episode here Support the show Support us on:  Patreon:  https://www.patreon.com/cw/IDIOTS_pod BuyMeA...

In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, finishes educating Callum and Jame (mostly Callum) on the concept of Microbiotoxicity! This episode is part 2 of 2. Here we discuss:  - What is microbiotoxicity? - Risk factors for microbiotoxicity - Which antibiotics are associated with microbiotoxicity? - Mitigating microbiotoxicity https://ww...

In this episode, the ID:IOTS Podcast Microbiome Correspondent Dr Anastasia "Tash" Theodosiou, returns to talk about her favourite subject!  This episode is part 1 of 2. Here we discuss:  - What is the microbiome - Viewing the microbiome as an organ system - The microbiome's association with disease - How we study the microbiome Stay tuned for part 2 (in 1-2 weeks depending on editin...

Join us for this special 80th episode celebrating Jame's favourite trial. https://www.nejm.org/doi/full/10.1056/NEJMoa1808312 Prep notes (including the images referred to in the poem) here .  Special thanks to the Wikiguidelines Endocarditis crew for their work summarising the evidence this poem was based on.  Support the show Support us on:  Patreon:  https://www.patreon.com/cw/IDIOTS_pod Bu...

Presenting: More on Penicillin-Binding-Proteins than you realistically ever need to know!  What is the difference between Gram positive and negative bacteria's cell walls? What is a Penicillin Binding Protein (PBP)? Why are they called PBPs? What do PBPs do? What makes MRSA resistant to (most) beta-lactams? These any many more questions answered! Notion page here - you'll need it for thi...

One PK table to rule them all One table to find them One table to bring them all And in the darkness blind them… …with awesome antibiotic PK facts you can use to bedazzle your friends and enemies alike! Prep notes here .  Support the show Support us on:  Patreon:  https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee:  https://www.buymeacoffee.com/idiotspod Prep notes for completed episodes can be fo...

The last Pharmacokinetics episode had finally been …Excreted!    This episode  covers the ‘drug out’ bit of pharmacokinetics, including things such as:    -What is clearance?  -how to calculate half life  and  -doesn’t everything leave through the kidneys anyway? (That is sort of true, also shut up).    Check out our prep notes (including for this episode) here .  Support the show Support us on: ...

It's the second Pharmacokinetics episode you never knew you wanted! Let’s talk about how antibiotics are distributed around the body once absorbed, using the examples of Amoxicillin and CallumShutUpicillin (listen to episode for clarification). What exactly is the volume of distribution? Want a handy reference for the plasma protein binding of various antimicrobials? Then this is the episode...

It's the Pharmacokinetics episode you never knew you wanted! Callum didn't know either, but never mind that let's talk about how antibiotics are absorbed, and how we can use that to improve our use of them in clinical practice. Want ammunition for that oral switch? Got someone who's doubting oral antibiotics' effectiveness? Then this is the episode for you! Check out our p...

In this final episode of the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the (mostly historical) pathogen Burkholderia mallei, causative agent of Glanders.  We did it. We got to the end.  Nonfermentors... Nobbled.  Support the show Support us on:  Patreon:  https://www.patreon.com/cw/IDIOTS_pod BuyMeACoffee:  https://www.buymeacoffee.com/idiotspod Prep notes for completed episo...

Post-publication, Callum and Jame give a little extra information on the SABATO trial in its final form compared to it's pre-publication state. Final article here: Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial , Kaasch, Achim J Valiente, A...

JOURNAL CLUB, YO, IT’S A SABATO!!! Join Jame and Callum as we travel back in time to when we recorded this deep dive into the SABATO trial pre-print, now peer-reviewed and published in the Lancet ID! In the next episode we'll give a little update as to how the final article differs from the preprint (not much). We also talked about in our FIS Highlights Episode 3 . We loved this trial and we...

In this penultimate episode in the Nobbling the Nonfermentors mini-series, Jame and Callum discuss the regionally important neglected tropical disease Melioidosis, caused by Burkholderia pseudomallei. This episode was based disproportionately on the following article, and we extend our thanks to the authors for thoughfully publishing it so close to us wanting to do a podcast episode on Melioid! Me...

In this Episode, Callum reflect on his recent runaway success passing the FRCPath Part 2, passes on some tips and tricks for the exam, and then we talk about what 3 antibiotics we would take with us to a Desert Island (that has all pathogens and environments where you would find said pathogens, so not just a desert apparently). 'Prepping to Pass' episodes mentioned: 40, 42, 43 & 50....

How do you think about antibiotics? This Christmas we give the best gift of all: no puns in an episode. Join Jame and Callum as they talk about a method for thinking about and explaining antibiotics. Here are the show notes for this episode: https://idiots.notion.site/69-Choosing-an-antimicrobial-4e7446a91ff6413aa14924a2ba905ffa  Support the show Support us on:  Patreon:  https://www.patreon.com/c...