CLDF Podcast

In this educational podcast, Paul Kwo, MD discusses how the goals of hepatitis B treatment are changing and what the future may look like for people living with chronic hepatitis B. While current medications do an excellent job of controlling the virus, most patients still need to stay on treatment long term. Dr. Kwo explains the growing focus on achieving a “functional cure,” which means losing t...

Dr. Anthony Martinez, Medical Director of Hepatology at the University at Buffalo and Erie County Medical Center, discusses the evolving landscape of chronic hepatitis B management and the shift from viral suppression to precision immune control. In this expert overview, he highlights the latest 2025 AASLD and EASL guideline updates and explains how quantitative hepatitis B surface antigen (qHBsAg...

In this expert discussion presented in collaboration with the Chronic Liver Disease Foundation, Amanda Cheung, MD, transplant hepatologist at Northwestern Medicine, and Peter Hedera, MD, neurologist and medical geneticist at University of Louisville, explore the complex challenges of medication adherence and long-term compliance in patients with Wilson disease. This educational conversation review...

This educational podcast from the 6th Liver Connect meeting provides a comprehensive overview of the TIPS (transjugular intrahepatic portosystemic shunt) procedure, focusing on patient selection, risk stratification, and evolving techniques to improve outcomes in patients with advanced liver disease. The discussion highlights key indications for TIPS, including recurrent or high-risk variceal blee...

In this high-level hepatology update from the 6th Annual Liver Connect Conference, Sujit Janardhan, MD, PhD, provides an overview of how the understanding and management of cirrhosis and portal hypertension are evolving in 2026. The discussion focuses on the big-picture shifts in the field, including earlier identification of patients at risk, updated definitions of disease progression, and how th...

In this engaging CLDF podcast episode, Fred Gordon, MD, and Valentina Medici, MD, explore the fundamentals of Wilson’s disease and why it remains one of the most challenging liver conditions to recognize in clinical practice. The conversation focuses on the importance of awareness, highlighting how this rare disease can present in many different ways and often goes overlooked or misdiagnosed. List...

In this insightful CLDF podcast recorded at the 6th Annual Liver Connect Conference, John Vierling, MD, shares a forward-looking overview of Wilson’s disease and the major shifts shaping its future diagnosis and management. This episode explores why Wilson’s disease remains difficult to recognize, often going undiagnosed for years due to its wide range of symptoms and its ability to mimic more com...

In this informative CLDF podcast, Sammy Saab provides a clear, big-picture overview of cirrhosis and portal hypertension, breaking down how clinicians approach this complex condition in today’s evolving healthcare landscape. Rather than focusing on technical details, this discussion highlights the key ways cirrhosis impacts the body and why early recognition, ongoing monitoring, and coordinated ca...

In this educational overview, Ethan Weinberg, MD, breaks down the fundamentals of portal hypertension and when to consider TIPS (transjugular intrahepatic portosystemic shunt) in clinical practice. The discussion highlights how clinically significant portal hypertension (CSPH) is diagnosed using both invasive and non-invasive methods, and reviews first-line management with non-selective beta block...

Learn best practices for identifying, risk stratifying, and managing patients with metabolic dysfunction–associated steatohepatitis (MASH) in this expert-led webcast featuring insights from Dr. Sammy Saab. As MASH continues to rise as a leading cause of cirrhosis, liver cancer, and liver transplantation, this session explores the evolving clinical approach to evaluation and treatment in the contex...

Explore the latest treatment strategies and emerging trends in metabolic dysfunction–associated steatohepatitis (MASH) with expert insights from Dr. Nadege Gunn. This video covers current FDA-approved therapies for patients with moderate to advanced fibrosis, including Resmetirom (Rezdiffra) and Semaglutide, and explains how lifestyle interventions remain the foundation of care. Learn how to perso...

This educational podcast with Dr. Sobia Laique from the 6th Annual Liver Connect meeting reviews key updates in the management of portal hypertension, focusing on improving outcomes beyond first variceal bleed prevention. The discussion highlights the advantages of carvedilol over propranolol, including its dual mechanism and greater reduction in portal pressure, with evidence supporting its role...

This educational video featuring Dr. Rustgi reviews key updates in hepatology, including HCC surveillance in compensated cirrhosis and the emerging role of liquid biopsies for earlier, more accurate cancer detection. It highlights the limitations of traditional tools like ultrasound and AFP, while introducing advances such as circulating tumor DNA and other minimally invasive biomarkers. The discu...

In this educational video, Dr. Kimberly Brown, transplant hepatologist at Henry Ford Hospital, reviews key strategies for monitoring and managing patients with chronic hepatitis B in clinical practice. She outlines the primary goals of treatment—preventing progression to cirrhosis, liver cancer, liver failure, and transplantation while also reducing the risk of viral transmission. The discussion h...

In this educational video, Christopher Bowlus, MD, the Chief of Gastroenterology at the University of California Davis and Lena Valente Professor, provides a comprehensive overview of current pharmacologic and non-pharmacologic strategies for managing pruritus (itch) in patients with Primary Biliary Cholangitis (PBC). He explains why pruritus is one of the most common and under recognized symptoms...

In this video, Aparna Goel, MD, associate professor of medicine at Stanford University, reviews the impact of pregnancy on primary biliary cholangitis (PBC) and key considerations for managing pregnant patients with autoimmune liver disease. The discussion covers how pregnancy affects PBC laboratory markers, including the limitations of alkaline phosphatase as a biomarker, common symptom changes s...

In this overview, Tatyana Kushner, MD, reviews key aspects of hepatitis B pathophysiology with a focus on covalently closed circular DNA (cccDNA) and its role in viral persistence and barriers to cure. She explains how cccDNA is established and maintained within hepatocytes, how host epigenetic regulation influences viral transcription, and why current antiviral therapies are unable to eliminate c...

In this episode, Dr. Robert Wong from Stanford University School of Medicine discusses the importance of patient-centered care and the role of patient-reported outcomes in the comprehensive management of chronic hepatitis B. Dr. Wong explains how PROs capture patients’ perspectives on their physical, mental, and social well-being—critical yet often underrecognized components of care. He highlights...

In this episode, Dr. Robert Wong from the Division of Gastroenterology and Hepatology at Stanford University School of Medicine discusses the value of patient-centric care and patient-reported outcomes in managing Primary Biliary Cholangitis (PBC). While traditional care often focuses on liver function tests and biochemical markers like alkaline phosphatase, Dr. Wong emphasizes the equal importanc...

In this expert discussion, Dr. Paul Kwo, hepatologist at Stanford University, explores the critical importance of patient adherence to treatment for chronic hepatitis B. Hepatitis B remains a global public health challenge and a leading cause of liver cancer—and yet in the U.S., many individuals remain undiagnosed or untreated. Dr. Kwo outlines how to assess disease stage, when to initiate antivir...

Join Dr. Ira Jacobson, Professor of Medicine at NYU Langone Health, for an in-depth exploration of the complex pathophysiology of chronic hepatitis B. In this expert lecture, Dr. Jacobson reviews the virologic and immunologic mechanisms that underpin HBV infection, from viral entry into hepatocytes and the formation of covalently closed circular DNA (cccDNA), to the integration of viral DNA and it...

In this expert video, Dr. Robert Gish—renowned hepatologist and Medical Director of the Hepatitis B Foundation—discusses the critical role of quantitative hepatitis B surface antigen (HBsAg) testing in the management and long-term monitoring of chronic hepatitis B. With over a decade of experience using quantitative HBsAg in clinical practice, Dr. Gish explains how this highly sensitive test compl...

In this expert highlight, Dr. Robert Wong shares essential tips for monitoring and managing patients with Primary Biliary Cholangitis (PBC). He outlines key goals after diagnosis, including evaluating liver disease severity through imaging and lab-based non-invasive testing, and assessing treatment eligibility. Dr. Wong explains the importance of monitoring alkaline phosphatase (ALP) levels—not on...

Join Dr. Alan Bonder, Associate Professor of Medicine at Harvard Medical School and Medical Director of Liver Transplantation, for an expert overview on the latest AASLD guideline updates for Primary Biliary Cholangitis (PBC). This in-depth session highlights key diagnostic criteria—such as AMA positivity, elevated alkaline phosphatase, and histologic confirmation—and walks through evidence-based...

Thank you Gilead Sciences, Inc. for your support on this FAQ Video Module. In this practical and patient-focused video, Dr. Nadege Gunn, a hepatologist based in Waco, Texas, shares essential diet and lifestyle strategies for individuals living with Primary Biliary Cholangitis (PBC). Addressing a common question—“What can I eat or do to feel better?”—Dr. Gunn highlights the benefits of a balanced,...