AZense Journal Club

Journal Club E33: SELECT: Semaglutide for Cardiovascular Outcomes in Obesity Without Diabetes 24.11.2025 7:24 ↓

In adults with established cardiovascular disease and obesity but no diabetes, weekly semaglutide reduced major adverse cardiovascular events by 20%. Here is what hospitalists need to know.

Journal Club E32: DAPT-SHOCK-AMI: IV Cangrelor vs Crushed Ticagrelor in Cardiogenic Shock 17.11.2025 7:04 ↓

Is IV cangrelor superior to crushed ticagrelor for antiplatelet effect and clinical outcomes in STEMI with cardiogenic shock?

Journal Club E31: PARTHENOPE: Personalizing How Long to Take Blood Thinners After a Stent 10.11.2025 7:00 ↓

Is personalized DAPT duration (using DAPT score) better than standard 12-month DAPT after PCI?

Journal Club E30: DIGIT-HF: Should We Bring Back Digitoxin for Advanced Heart Failure? 03.11.2025 7:10 ↓

Does digitoxin reduce death or HF hospitalization in patients with HFrEF on guideline therapy?

Journal Club E29: DanGer Shock at 10 Years: Does Impella Keep Paying Off in STEMI Shock? 27.10.2025 7:00 ↓

Does the survival benefit of Impella CP in STEMI shock persist over 10 years?

Journal Club E28: ALONE-AF: Should You Stop Anticoagulation After a Successful AF Ablation? 20.10.2025 6:55 ↓

In arrhythmia-free patients after catheter ablation for AF, is stopping oral anticoagulation safe compared to continuing?

Journal Club E27: Carvedilol vs propranolol: preventing decompensation in cirrhosis 13.10.2025 7:08 ↓

Two large 2025 studies push carvedilol to the front of the formulary for portal hypertension. Here is what the evidence says, where the guidelines stand, and how to translate this at discharge.

Journal Club E26: HI-PEITHO: Catheter-directed thrombolysis for intermediate-risk PE 06.10.2025 6:49 ↓

Does ultrasound-facilitated catheter-directed fibrinolysis reduce decompensation in intermediate-risk pulmonary embolism?

Journal Club E25: ADAPT-Sepsis: PCT-Guided Antibiotic De-escalation in ICU Sepsis 29.09.2025 6:52 ↓

Can daily procalcitonin-guided decision-making safely shorten antibiotic duration in ICU sepsis compared to standard care?

Journal Club E24: STRONG-HF: Rapid GDMT Up-Titration After Acute Heart Failure Hospitalization 22.09.2025 6:35 ↓

Does rapid up-titration of all four GDMT pillars starting before discharge reduce 180-day HF readmission or death?

Journal Club E23: Prosty et al.: Antibiotic Prophylaxis in Cirrhosis with Upper GI Bleeding 15.09.2025 5:34 ↓

Is routine antibiotic prophylaxis for 5 to 7 days actually necessary for cirrhosis patients presenting with upper GI bleeding?

Journal Club E22: STEP-HFpEF: Semaglutide in Obesity-Related Heart Failure with Preserved Ejection Fraction 08.09.2025 6:37 ↓

Does semaglutide improve symptoms, function, and weight in patients with obesity-related HFpEF?

Journal Club E21: HIT Trial: Targeted Correction of Hyponatremia in Hospitalized Patients 01.09.2025 5:34 ↓

Does a structured, multifaceted algorithm for correcting chronic hyponatremia reduce mortality and rehospitalization in hospitalized patients?

Journal Club E20: MINT Plus AABB 2025 Guideline: Transfusion in Acute MI with Anemia 25.08.2025 6:14 ↓

What hemoglobin threshold should trigger a transfusion in a patient with acute MI and anemia?

Journal Club E19: BLING III: Continuous vs Intermittent Beta-Lactam Infusion in ICU Sepsis 18.08.2025 6:05 ↓

Does infusing piperacillin-tazobactam or meropenem as a continuous drip improve 90-day survival compared to standard intermittent dosing in ICU sepsis?

Journal Club E18: SABATO: Oral Switch Therapy in Low-Risk Staphylococcus aureus Bacteremia 11.08.2025 6:01 ↓

Can we safely switch low-risk Staph aureus bacteremia patients to oral antibiotics after 5 to 7 days of IV therapy?

Journal Club E17: DAPA ACT HF-TIMI 68: In-Hospital SGLT2 Initiation in Acute Heart Failure 04.08.2025 6:00 ↓

Should SGLT2 inhibitors be started during a heart failure hospitalization rather than waiting until after discharge?

Journal Club E16: EMPACT-MI: Empagliflozin After Acute Myocardial Infarction 28.07.2025 6:44 ↓

Does empagliflozin started early after high-risk acute MI prevent heart failure hospitalization or death?

Journal Club E15: When Thrombectomy Is Not the Answer: DISTAL and ESCAPE-MeVO 21.07.2025 6:42 ↓

DISTAL and ESCAPE-MeVO: No Benefit (and Possible Harm) from EVT in Medium-Vessel Stroke

Journal Club E14: Transfusion Thresholds in Brain Injury: The TRAIN Trial 14.07.2025 6:02 ↓

TRAIN: Liberal Transfusion Threshold Improves Neurological Outcomes in Acute Brain Injury

Journal Club E13: Preventing Pancreatitis: Olezarsen and the CORE-TIMI 72 Trials 07.07.2025 6:36 ↓

CORE-TIMI 72: Olezarsen Cuts Acute Pancreatitis Risk by 85% in Severe Hypertriglyceridemia

Journal Club E12: A New Mechanism for Resistant Hypertension: Launch-HTN and Lorundrostat 30.06.2025 6:50 ↓

Launch-HTN: Lorundrostat, an Aldosterone Synthase Inhibitor, Achieves Significant BP Reduction in Treatment-Resistant Hypertension

Journal Club E11: Catheter Thrombectomy for High-Risk PE: The STORM-PE Trial 23.06.2025 6:53 ↓

STORM-PE: Catheter Thrombectomy Outperforms Anticoagulation Alone in Intermediate-High-Risk Pulmonary Embolism

Journal Club E10: Cefazolin Steps Up: The CloCeBa Trial for MSSA Bacteremia 16.06.2025 6:30 ↓

CloCeBa: Cefazolin Is as Effective as Cloxacillin for MSSA Bacteremia and Far Less Toxic

Journal Club E09: When Provoked Is Not Simple: The HI-PRO Trial 09.06.2025 6:19 ↓

HI-PRO: Extended Low-Dose Apixaban Cuts Recurrent VTE by 87% in Provoked Patients with Ongoing Risk