AZense Journal Club

After the positive CAPE COD trial and the messy, neutral REMAP-CAP result, does hydrocortisone still reduce mortality and mechanical ventilation in severe CAP, and in whom?

After the neutral CLEAR-SYNERGY trial, does low-dose colchicine still have a role in chronic coronary disease and after acute coronary syndrome?

In prior-MI patients with an ICD and ventricular tachycardia who have not failed drug therapy, is first-line catheter ablation better than antiarrhythmic drugs?

In truly asymptomatic severe aortic stenosis with preserved ejection fraction, does early transcatheter aortic valve replacement beat watchful waiting?

In intermediate-high risk pulmonary embolism, is large-bore mechanical thrombectomy superior to catheter-directed thrombolysis for preventing deterioration and bleeding?

In non-intubated ICU patients with hyperactive delirium, does dexmedetomidine shorten delirium duration compared with placebo, without the respiratory depression of standard sedatives?

Can an AI early warning system built from nursing surveillance documentation improve hospital ward outcomes, or does it just create more alerts?

In adults with newly reduced LVEF from non-ischaemic cardiomyopathy or recent myocardial infarction on contemporary 4-pillar GDMT, what is the rate of life-threatening ventricular arrhythmias captured by a wearable cardioverter-defibrillator during the early high-risk window before permanent ICD candidacy is established?

In adults at increased risk of acute kidney injury after major noncardiac surgery, does urinary biomarker-triggered application of the Kidney Disease Improving Global Outcomes (KDIGO) acute kidney injury bundle reduce moderate to severe acute kidney injury?

Do patients of female physicians have different mortality and readmission rates compared to patients of male physicians?

In opioid-naive adults undergoing major noncardiac surgery, does routine perioperative gabapentin or pregabalin reduce opioid use and pain without unacceptable harms?

Is tirzepatide non-inferior to dulaglutide for MACE prevention in T2DM with established CVD?

Does targeting albumin infusions to maintain levels >=30 g/L reduce complications in hospitalized cirrhosis patients?

Does early diagnostic paracentesis (within 12-24h of admission) improve outcomes in hospitalized cirrhosis patients with ascites?

For intermediate-risk PE with RV dysfunction, when should advanced therapy (CDT or thrombectomy) be used?

Does surgical LAA occlusion during cardiac surgery reduce stroke in AF patients?

In hospitalized adults with complicated Staphylococcus aureus bacteremia who cleared blood cultures after 72 hours to 10 days of intravenous therapy, can two weekly dalbavancin doses complete therapy compared with 4 to 8 weeks of standard intravenous therapy?

Does piperacillin-tazobactam increase AKI compared to cefepime? Does either antibiotic cause more neurotoxicity?

Is early transition to oral antibiotics safer and equally effective compared to continued IV therapy for serious infections?

Is rapid correction of severe hyponatremia associated with worse outcomes (ODS) or better outcomes (lower mortality)?

Does empagliflozin reduce CKD progression in a broad population including non-diabetic patients?

Does indication-based conservative dialysis improve kidney recovery vs scheduled thrice-weekly dialysis in AKI?

Does phenotype-guided immunotherapy (anakinra for MALS, interferon-gamma for immunoparalysis) improve sepsis outcomes?

In AECOPD with hypercapnic respiratory failure, is HFNC or NIV the better initial respiratory support?

Does IV hydrocortisone reduce mortality in ICU-admitted patients with severe CAP?