AMiNDR: A Month in Neurodegenerative Disease Research

Deciding what to do during your lunch break or out on a stroll? Well, look no further! Listen in on Abdullah covering the latest papers from February 2021 covering the treatments targeting glia, immune cells, proteostasis and autophagy. Tune in to learn about out of the box ideas that may hold therapeutic benefits for Alzheimer's Disease.     Sections in this episode:   Targeting the Immune System...

Judy covers a wide range of neuroimaging modalities in the context of metabolics, hemodynamics and functional connectivity in AD. Tune in if you're a fan of fMRI, PET and EEG, or if you're just looking to learn something new!     Sections in this episode:   fMRI (1:06)   PET (7:28)   EEG (16:29)   fNIRS (20:16)   Other (23:12)  --------------------------------------------------------------  To acc...

Elyn is back to guide your through all of the connections between blood vessels and Alzheimer disease, from papers published in February 2021. Starting the episode off with how midlife vascular risk factors can influence AD risk, and finishing with treatments for AD that target the vasculature, you're sure to leave this episode appreciating how intertwined heart health and brain health are. Well w...

In this short episode packed full of insight, Jacques navigates the realms of amyloid-beta toxicity in AD. Learn about different techniques and models used to investigate amyloid-beta toxicity, how mouse models can provide insight into toxic amyloid-beta species and the relationship of certain amyloid-beta species with clinical presentations.     Sections in this episode:   Techniques for Investig...

Courtney guides you through the latest papers on the immune system and glial cells in the context of Alzheimer's Disease. This includes papers on microglia, astrocytes, and advances in methods to study inflammation in neuroscience. Enjoy!     Sections in this episode:   Microglial Pathway and Receptors (2:44)   Tying Microglia to Astrocytes (19:37)   Astrocytes (22:20)   Models and Methods to Stud...

Follow along with Alex in this episode, as we take a closer look at papers studying amyloid and tau PET targets in Alzheimer's Disease, as well as some new PET targets at the end of the episode.  We'll cover topics including deep learning, cerebral amyloid angiopathy, and using the retina as a way of indirectly accessing the brain!     Sections in this episode:   Amyloid and tau-based detection (1...

A huge focus of Alzheimer's Disease research is understanding the mechanisms behind behavioural symptoms and how to treat them. In this episode, Ellen takes you through papers published in February on topics such as autobiographical memory, sex differences, decision-making, sensory processing, depression, sleep, and so much more!     Sections in this episode:   Cognition (2:43)   Sensory processin...

Marcia is back to update you on the latest Alzheimer's research. Today's episode is all about RNA, transcription, translation, proteomics, and more, all in the context of AD. Enjoy.     Sections in this episode:   RNA & Transcription (1:00)   Translation & Proteomics ( 12:28)   Miscellaneous (16:26)  -------------------------------------------------------------- You can find the bibliography for t...

Want to learn more about how changes in synaptic function, structure and plasticity are implicated in neurodegenerative disease pathology? We've got you covered with this episode! Glory will guide you through 18 papers from February 2021 that explore mechanisms which underlie the synaptic dysfunction that can lead to Alzheimer's disease, ranging from the molecular level to the more global level of...

In this episode, Jacques runs through February 2021's papers on APP processing and amyloid-beta aggregation. Learn about key residues underlying amyloid-beta aggregation, fibrillogenesis-promoting factors and interesting co-pathologies!     Sections in this episode:   APP processing (1:35)   Amyloid beta aggregation (10:50)  -------------------------------------------------------------- To access...

Curious about ketogenic diets, insomnia and loneliness? Then this episode is just for you! Join Naila as she goes through 23 new epidemiological studies of AD that were published in February 2021, and cover a wide range of potential risk or protective factors of AD.  Sections in this episode:  Disease prevalence and progression (1:56)  Air pollution (4:42)  Smoking and Atherosclerosis (9:04)  Psyc...

In this episode, Courtney takes you through the papers from February 2021 on understanding ApoE in Alzheimer's disease and through a few papers on the familial mutations in Alzheimer's disease. There is a wide range of topics so be sure tune in for this exciting episode!  Sections in this episode:  Cognitive impairment with APOE (2:30)  Brain banks to model and predict AD progression (8:56)  Mecha...

To kick of the February 2021 series, Anusha guides you through papers recently published that target synaptic health and  acetylcholinesterase activity to uncover pathological mechanisms that underlie Alzheimer's disease. If you like thinking about thinking, look no further than this episode!     Sections in this episode:   Synaptic Plasticity and Preservation (2:05)   Oxidative Stress (8:52)   Mi...

Welcome to the baptists, the tauists, and all protein aggregation and misfolding enthusiasts from the beautiful realm of neuroscience. This episode is for you if you study amyloid-beta aggregation and toxicity in Alzheimer's disease. You will hear about fibrillar assembly, staining techniques to identify those sneaky aggregates, and strategies to inhibit this process in the hope of developing targ...

In this episode we’ll cover all things metabolism, hemodynamics and connectivity in the brain, in AD. We’ll cover 26 papers published in January 2021, that dive deeper into these research topics, so tune in!     Sections in this episode:   Metabolism (1:42)   Hemodynamic (4:28)   Connectivity changes (11:46)   Miscellaneous (24:56)  -------------------------------------------------------------- To...

Join Naila for 24 papers published in January 2021 on preventive strategies and non-pharmacological interventions for treating AD. She’ll catch you up on the latest exercise interventions, the various diets under investigation for AD prevention, invasive and non-invasive stimulation techniques, cognitive therapy and a few miscellaneous papers.     Sections in this episode:   Exercise and Physical...

Anusha is your guide through 14 papers which target neurotransmitter balance. These papers were all published in January 2021 and focus mostly on targeting acetylcholinesterase activity with a sprinkling of other targets such as NMDA receptors. If you love synapses and are dying to find out how we can get them working properly again in AD, make sure to give this episode a listen!     Sections in t...

In this episode, Maria covers papers from January 2021 exploring cognitive and neuropsychiatric assessments that can be used to evaluate early AD or progression to AD.  The studies look at tests and questionnaires related to learning and memory, functional status, and neuropsychiatric symptoms, including online adaptations of cognitive assessments when in-person visits are not always possible.    ...

In this episode, Courtney takes you through the papers from 2021 on the role of Immune systems and glial cells in Alzheimer's disease pathology. The papers relate to neuroimaging, astrocytes, microglia, and  broader inflammatory topics and pathways. Be sure to tune in for this exciting episode!     Sections in this episode:   Neuroimaging and Alzheimer's disease (2:01)   Methods of studying inflam...

In this episode, the first of a two-part mini series, Jacques runs through papers from January 2021 on amyloid-beta oligomers in aggregation and therapeutics strategies to target them. Tune in to hear about conformational changes, molecules that affect oligomerisation, oligomer conformation-specific treatment strategies and more!     Sections in this episode:   Oligomerization/Conformation, etc. (...

The rapidly evolving field of Alzheimer’s research is always discovering new genes, variants or even pathways that are associated with this disease. In this episode, Joseph goes over 14 studies from January 2021 that explored novel genes or novel variants, or even studied the associations of novel pathways with AD.     Sections in this episode:   Association studies with gene networks and polygeni...

Learn about the studies from January 2021 that used imaging to investigate structural changes in Alzheimer's disease. This includes imaging of different brain regions, as well as other structures like the retina. By better understanding these changes, we can learn more about the disease's pathology and mechanisms, which could lead us to the ability to better treat this disease, or detect it at ear...

In this episode, Marcia will take you through papers from January 2021 that involve research on targeting mitochondria, metabolism and oxidative stress as effective therapeutic strategies against AD. Tune in to hear about the relation between AD, diet and metabolic diseases like diabetes, the use of nanotechnology and organelle-specific agents to deliver therapy, and more!     Sections in this epi...

Ellen covers papers published this past January on cognitive and neuropsychiatric symptoms in AD and the mechanisms behind them. You'll hear about sensory processing, cognitive and memory deficits, psychiatric symptoms and emotions, and sleep and circadian rhythms in the context of AD. Tune in to learn about the potential mechanisms behind these symptoms, and how they correspond to disease progres...

 In this episode, Abdullah will cover the latest papers from January 2021 covering development of potential treatments targeting glia, immune cells, proteostasis and autophagy. Tune in to learn about out-of-the-box ideas like how rotten eggs and silver apricots may hold therapeutic benefits for Alzheimer's Disease.     Sections in the episode:   Microglia (3:46)   Astrocytes (7:17)   Glial cells i...