AMiNDR: A Month in Neurodegenerative Disease Research

In this episode, Courtney takes you through the papers from May 2021 on Understanding ApoE in Alzheimer's disease! We will be covering papers focused on genetic risk factors, biomarkers associated with ApoE status, risk factors for AD and finally, molecular mechanisms of ApoE! There is a wide range of topics so be sure tune in for this exciting episode!   Sections in this episode: Genetic Risk Fac...

Ellen kicks off the May 2021 series with 20 papers all about synaptic transmission in Alzheimer's Disease. This includes topics like synaptic plasticity, neurotransmitters like acetylcholine, dopamine, and serotonin and how they're involved in AD, growth factors, morphological changes, and much more! Enjoy the show!   Sections in this episode: Neurogenesis (5:11) Synaptic Plasticity (8:46) Neurotr...

If you are interested in oxidative stress in Alzheimer’s disease, mitochondrial dysfunction, or metabolism, come hear about the ways they can be targeted for therapeutic purposes. Maybe you are tired of hearing about cholinesterase inhibitors or anti-amyloid-beta antibodies and want to explore something different. Tune in with Sarah in this last episode for our series on the papers published in Ma...

In this short episode, Joseph goes over 9 studies published in March 2021 that include GWAS’s, ethnicity-specific genetic studies and research on familial AD genetics. Tune in to learn more!   Sections in this episode:   GWAS and other population level studies (2:22)   Ethnicity Specific Studies (7:44)   Familial AD Genetics (11:28)   -------------------------------------------------------------- ...

Jacques takes you on a journey through 22 papers on amyloid-beta & aggregation. Ranging from new techniques for amyloid-beta detection, APP-processing, co-pathology & Prion-like mechanisms and some miscellaneous topics pioneering the AD field. Guess you'll just have to stick around until the end!  Sections in this episode:  Amyloid-beta processing (2:02)  Amyloid-beta detection (13:00)  Amyloid-be...

In this episode, you'll hear about the latest research on targeting neuroinflammation, glial cells, autophagy and proteoastis to treat Alzheimer's Disease. This includes some studies that want to increase neuroinflammation and some that want to decrease it! How can they both work? You'll have to listen to find out.  Sections in this episode:  Treatments targeting Neuroinflammation and Neurodegener...

In Part 2 of Clinical Markers of AD, Naila will take you through 10 papers on the diagnostic and prognostic value of neuropsychiatric, sensory, motor, or a combination of symptoms. You'll learn about pareidolia, extrapyramidal symptoms, wandering behaviour and more!  Sections in this episode:  Multiple Symptoms (2:47)  Neuropsychiatric Symptoms (6:51)  Sensory Symptoms (11:05)  Motor Symptoms (18:...

In part 1 of the clinical markers of AD episodes, Ellen will tell you about papers from March 2021 all about cognition. This includes papers on new cognitive tests, improving or adapting old ones to new situations, learning more about how useful these different assessments really are, AND some really cool papers at the end on new technology and machine learning tools to make AD diagnosis and detec...

Transcriptional and translational dysregulation may cause changes in cellular biology and can lead to disease. In this episode, Marcia brings you the latest research in March 2020 that focus on changes in gene & protein expression and epigenetics in the context of Alzheimer’s disease. Some common terms you’ll hear throughout this episode are transcriptomics, methylome, biomarkers, proteomics, AD m...

In today's episode, we'll be taking a closer look at papers published in March 2021, studying amyloid and tau PET targets in Alzheimer's Disease, as well as some new PET targets.  Topics covered include but are not limited to: butyryrlcholinesterase targeting, PET image processing, and animal models.   Sections in this episode:  Amyloid/Tau PET Targets   Tau pathology (1:08)   PET image processing...

We've got a tour de force of prevention and intervention papers for you today, covering vascular function, cognitive function, diet, exercise, neuromodulatory techniques and stem cell therapies. Naila will take you throuh 20 papers to update you on the AD literature from March 2021!  -------------------------------------------------------------- You can find the bibliography for this episode by cl...

In this episode, Courtney takes you through the papers from March of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, systemic inflammation and so much more! Tune in for this exciting episode!   Sections in this episode:  Systemic Inflammation (2.02)  Neuroinflammatio...

Tune in as Ellen updates you on all things cognition and behaviour in Alzheimer's disease. Particularly, she'll tell you about new studies from March 2021 that shed light on the characteristics of cognitive and behavioural symptoms in AD, and the underlying neural mechanisms. This episode covers a lot of ground -- memory, executive function, the sense of smell, depression, chewing, and so much mor...

Tired of the age-old amyloid cascade hypothesis? So is Elyn! Join her in this episode unpacking papers that showed up on PubMed in March 2021 that add more evidence to the tight intertwinement of vascular and brain health. Topics in this episode range from mechanistic studies in animal models looking at cerebral blood flow and blood-brain barrier integrity, all the way to clinical studies mapping...

In this shorter episode, Judy goes through metabolic changes, hemodynamics and functional connectivity papers on Alzheimer's disease, all published in March 2021. Aside from our favorites PET, MRI and EEG, we also look into studies that use less common techniques like SPECT imaging, retinography and MEG. Join us for just 20 minutes of neuroimaging fun!  Sections in this episode:  PET (1:05)  MRI (...

Follow along with Glory in this episode, as we dive into papers that try to uncover the link between changes in synaptic transmission and plasticity with cognitive decline and memory loss in Alzheimer's disease. We'll discuss the most recent research on molecular and structural mechanisms at the synapse that underlie Alzheimer's pathology! Tune in for topics such as presynaptic SNAREs, postsynapti...

In part 2 of epidemiological studies from March 2021, a particularly loopy, end-of-week Naila will take you through 22 papers on comorbidities and health conditions linked to Alzheimer's disease. We've got some papers on general frailty and comorbidity burden, treatments for other diseases, sleep apnea, cardiovascular risk factors and vision impairment.  Sections in this episode: Comorbidities in...

In part 1 of epidemiological studies from March 2021, Naila will take you through 12 papers covering prevalence and incidence rates of AD, sociodemographic factors, the potential effects of loneliness, and more. Follow up with Part 2 if you'd like to learn about comorbidities and health risk factors linked to AD!  --------------------------------------------------------------  You can find the bib...

Anusha will be summarizing for you papers published in March of 2021 that address neuronal and synaptic health in models of Alzheimer’s disease. That’s not all! We are also going to explore the topic of restoring neurotransmitter balance. So if for instance, you’re looking for research on acetylcholinesterase inhibition, this episode is for you!  Sections in this episode:  Targeting neuro/synaptic...

Hooray! The first episode of our March 2021 series is here! In this episode, Courtney takes you through the papers from March 2021 on Understanding ApoE in Alzheimer's disease! We will be covering papers focused on ApoE in cognition, ApoE on biomarkers and pathology, and mechanisms of ApoE! There is a wide range of topics so be sure tune in for this exciting episode!     Sections in this episode:...

Twin studies, GWAS, TWAS, EWAS and more - In this episode, Joseph takes you through 20 papers published in February 2021 that explore novel genes or variants associated with Alzheimer’s Disease, studied associations of novel pathways to AD or link molecular pathways of other diseases to AD.   Sections in this episode:   Comorbidities and other conditions (1:28)   Identification and Validation of R...

Ellen is bringing you Part 2 of our series on cognitive & clinical indicators to diagnose AD! Make sure to check out episode 143 for Part 1! In Part 2, you'll learn about the latest research validating old & new cognitive tests for AD and mild cognitive impairment, how motor and muscular symptoms can be used to diagnose AD, how body temperature relates to this disease, and the latest in machine le...

In part 1, Naila will take you through 17 papers on characterizing different cognitive profiles of Alzheimer's disease, comparing cognitive measures to pathological biomarkers, optimizing visual and memory tasks, and examining how subjective measures of cognitive decline relate to objective tests. Be sure to check out Part 2 for test validation, motor tasks, and machine learning!  Sections in this...

Marcia is back to bring you the latest in Alzheimer's disease treatment development! Join us as we explore the complex relationship between AD and metabolic disorders like diabetes, and some therapies used to co-treat them. Not enough? We also talk about oxidative stress and mitochondrial dysfunction, and (some new!) compounds aimed at mitigating these. Tune in to get your neurons firing!  Section...

Naila provides an overview of February 2021 papers related to preventative factors and non-pharmacological interventions for AD. You'll hear about physical activity, the ketogenic diet, transcranial magnetic stimulation, and dogs! Quite the range in just 20 papers.   Sections in this episode:   Lifestyle/Multiple Factors (1.56)   Physical Activity (5.27)   Diet (14.45)   Social/Emotional Wellbeing...