AMiNDR: A Month in Neurodegenerative Disease Research

Here, we'll be taking a closer look at 14 papers published in June 2021 that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to...

Interested in brain connectivity changes specific to Alzheimer's disease? Come join us as Judy presents 13 papers featuring fMRI, machine learning and other brain mapping techniques that explore functional connectivity in AD. You're sure to learn something new!   Sections in this episode:   fMRI (01:32)   Machine Learning (12:10)   Other (14:36)    -------------------------------------------------...

With a shorter epsiode than usual this month, Elyn is back with an update on vascular contributions to Alzheimer disease and potential treatment avenues targeting the vasculature. Tune in for a summary of 8 papers spanning clinical studies that unpack neuroimaging hallmarks of vascular changes in AD, all the way to mechanistic studies focused on understanding blood-brain barrier dysfunction in Alz...

Only 14 papers published on APP processing and Amyloid-beta aggregation in the month of June, what’s going on? Well, it is still our pleasure to give you brief summaries on the matter, so if you research Alzheimer’s disease, you do want to tune in for your monthly update on secretase activity, seeding of misfolding, metal ion content of aggregates, and amyloid-beta toxicity.   Sections in this epi...

In this short and sweet episode, Naila covers 12 papers from June 2021 regarding non-pharmacological strategies to prevent or intervene in dementia progression. You'll hear about a few exercise programs, some creative ways to improve quality of life for people with dementia and caregivers, and a range of neuromodulatory (stimulation) techniques.   Sections in this episode:   Exercise (1:37)   Mult...

Join our host Anusha as she takes you through papers published in June of 2021 that target neuroprotection as a potential treatment avenue for Alzheimer's disease. Half these papers use amyloid-beta induced models of Alzheimer's disease so be sure to check it out if neuroprotection is up your alley.   Sections in this episode:   Treatments targeting neuroprotection in amyloid-beta induced AD model...

In this shorter episode, Judy goes over papers published in June 2021 that focus on diagnostic tools of Alzheimer's disease. Topics include metabolic changes, hemodynamics and EEG biomarkers. Listen in to find out more!   Sections in this episode:   Metabolic changes in AD (1:20)   Hemodynamics (9:30)   EEG (13:30)    --------------------------------------------------------------  You can find the...

Curious about how neuronal hyperactivity and hippocampal synaptic plasticity impairment contribute to Alzheimer's pathology? Join Glory for the latest updates on research about the mechanisms of synaptic transmission and plasticity affected in Alzheimer's disease. This month, June 2021, delivers 17 new papers that will fill you in on all things synaptic in AD! Give it a listen to find out more and...

We know how critical gene expression and its regulation is to cellular homeostasis. In light of that, it is imperative that we discuss the possibility that Alzheimer’s disease could be caused by disturbances in DNA methylation in certain genes and the potential role of methylation in being a biomarker in AD. In today's episode, Marcia brings you the latest research on this topic, summarizing 9 pap...

Ellen kicks off this series by telling you about the latest research from June 2021 on topics like cognition, memory, reading, gait, speech, depression, sleep, and even more. Learn how these symptoms may manifest in Alzheimer's disease patients, and the underlying mechanisms that contribute to them. If you're interested in behaviour and cognition in humans or in animals, this episode is for you! ...

From standard clinical testing to motor assessments such as gait performance and handwriting ability, Judy will cover 10 papers on various types of markers in Alzheimer's Disease. Tune in for our final May 2021 episode and learn something new about the different techniques used in AD diagnosis!  Sections in this episode:  Clinical Testing (1:58)  Motor Assessments (7:39)  Semantic Dementia (11:28)...

In this episode, Maria goes over 22 papers from May 2021 on various cognitive tests for Alzheimer's disease and mild cognitive impairment. Paper topics include tests of general cognition, visual, verbal and auditory tests, dementia subtypes, machine learning, and language and culturally adapted tests.     Sections in this episode:   General cognition (2:00)  Visual, verbal, and auditory testing (1...

In the second part of our episodes on amyloid-beta, we focus on the ways abeta contributes to AD pathology. This ranges from its effects on the hippocampus and memory, to more mechanistic studies on ion homeostasis, lipid membrane integrity, and prion-like seeding, without forgetting our friend tau!  Tune in for an episode as eventful as an episode of Game of Thrones where amyloid-beta wages a war...

This episode of AMiNDR highlights literature published in May of 2021 that target neurotransmitter balance in Alzheimer's Disease. Greatest hits include cholinesterase inhibition, targeting glutamate excitotoxicity, and there's even a bonus paper on adrenergic transmission. Get excited! But maintain homeostasis.     Sections in this episode:   Targeting cholinesterases and oxidative stress (1.56)...

Wow - May 2021 is a productive month for AD genetics research! Tune in and Joseph will take you through 19 papers on studies to do with new variants, novel genetic insights, or studies on familial AD genetics.     Sections in this episode:   Methods for Gene and Pathway Discovery (1:46)   GWAS, Transcriptome, Exome Sequencing (5:47)   Miscellaneous (12:55)   Familial AD (17:11)    ----------------...

In this episode, Courtney takes you through the papers from May of 2021 on the Role of Immune systems and glial cells in Alzheimer's disease pathology! We will be discussing papers related to neuroinflammatory pathways in microglia and astrocytes, metabolism, peripheral inflammation and so much more! Tune in for this exciting episode!  Sections in this episode:   Microglia (02:07)   Astrocytes (10...

In part 2 of this set of episodes, Ellen dives into papers on psychiatric changes and sleep disturbances in the context of AD. This includes research looking at depression, anxiety, agitation, circadian rhythm, and more in AD patients, animal models, and even clinical trials! There's sure to be something for everyone in this diverse set of papers, enjoy!  Sections in this episode:   Depression (2:...

Hello hello to fellow baptists, tauists and all protein aggregation enthusiasts! Sarah brings you 15 papers from the month of May on Amyloid-beta aggregation! This is the first part of a 2 episode series on understanding the role amyoid-beta plays in Alzheimer’s disease pathology, and you will hear about APP processing and localization, then amyloid-beta generation and aggregation. We will also th...

In this episode, we’ll take a closer look at 13 papers published in May 2021, that rely on Positron emission tomography imaging (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer’s disease! Make sure to take a listen if you’re interested in learning more about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with diff...

In part one of this 2-parter, Ellen will tell you all about the latest studies on cognition and motor deficits in AD. This includes mechanistic studies, as well as studies looking at potential treatment avenues for these symptoms. We hope you enjoy, and stay tuned for part 2 coming out soon!  Sections in this episode:   Cognition in AD patients (4:09)   Cognition in animal models (9:38)   Motor im...

From working memory tasks to mouse models, and even to lexical semantics, Judy goes over a wide range of papers that study AD diagnosis using a variety of neuroimaging techniques. Check out this episode if you're interested in hearing about changes in cerebral blood flow, metabolism and EEG signals in the context of AD. You're sure to learn something new!  Sections in this episode:  Hemodynamics (...

Anusha will guide you through 21 papers in this episode that target synaptic and neuroprotection as therapeutic intervention for Alzheimer's disease. She covers 3 topics including the use of pre-existing synthetic compounds, naturally occuring compounds, and designing and optimizing drugs to improve efficacy. All of these papers were published in May of 2021 so be sure to check it out to offer you...

In this episode, Naila tackles 21 papers on diet, exercise, complementary therapies, cognitive training, and neurostimulation techniques. There's lots on the potential cellular mechanisms of exercise, several studies using Alzheimer's disease biomarkers as outcome measures, and even a paper on dog-assisted therapy! Hope you enjoy May's smattering of papers on pevention and intervention strategies...

Elyn is back with more on all things vasculature! In this episode, she covers 14 papers that span many topics in the field of vascular contributions to Alzheimer disease - all the way from mechanisms linking cardiovascular and metabolic health to the Alzheimer pathology, to clinical studies associating cognitive symptoms with markers of cerebrovascular damage. Tune in to hear a perspective on AD t...

Come join us as Judy covers all topics related to connectivity changes in Alzheimer's Disease. This episode features the latest research on both structural and functional connectivity using methods such as resting-state fMRI, DTI and EEG. Tune in to find out more!     Sections in this episode:   fMRI (2:00)   MRI (10:51)   Other (15:43)  ------------------------------------------------------------...