AMiNDR: A Month in Neurodegenerative Disease Research

Naila brings you 21 articles from January 2024, on non-pharmacological approaches to the prevention and intervention of Alzheimer's disease. You'll be treated to research from computational modeling, to rodent models, to clinical trials, with a particular focus on optimizing and personalizing intervention strategies. This episode also covers some research on the role of caregivers, and several pap...

Join Christy for 12 papers from January 2024 on structural neuroimaging in the diagnosis of Alzheimer's disease. This episode is a bit different from past ones because it's all about the use of machine learning and deep learning. Whether you're an AI researcher or simply curious about the topic, you won't want to miss this episode.   Detecting AD (3:42)   Predictions, associations or comparisons (...

Another series of AMiNDR kicks off with this episode. Anusha takes you through 7 papers published in January 2024 targeting neuroprotection in AD. If you'd like to hear about potential compounds that could reduce neurodegeneration in Alzheimer's disease, this is the episode for you. Testing for neuroprotection in cell lines (2:57) Testing for neuroprotection using in vivo AD models (11:47) -------...

Another special episode to help kick off our return! In what we hope to be a recurring special series, an interview with members in our scholarly community on navigating the multiple facets of life as a scientist. In the first episode, host Kevin Nishimura interviews one of our own Joseph Liang on his personal journey to and through graduate school. Tune in to learn what he has to say about gettin...

In today's episode, Naila provides an overview of 14 articles published in November 2023 on non-pharmacological interventions for AD. You'll hear about cognitive training, music therapy, chair yoga, providing support to caregivers, and a range of neural stimulation techniques. Enjoy!   Cognitive and Social Factors (2:26) Lifestyle interventions (13:40) Stimulation Techniques (19:20) --------------...

Join us as we cover a set of papers published in November 2023 on treatments targeting cholinergic transmission in Alzheimer's disease. In this episode hosted by Christy, we will go over various topics, from drug discovery using synthesized compounds to drug testing of plant extracts, as well as improving drug delivery through the blood-brain barrier. Enjoy!   Papers evaluating synthesized compoun...

As we get back up to speed on our regular episodes, we thought we'd treat you (and ourselves) to something out of the ordinary: a conversation on how visual storytelling can shape how we think - and feel - about Alzheimer's disease. Host Naila Kuhlmann had the pleasure of interviewing Gina Martin, who founded the Bob and Diane Fund to support and promote visual storytelling about Alzheimer's and d...

Hello listeners, it’s been a while since we last released an episode but we are back with another series here at AMiNDR bringing you a synopsis of publications on Alzheimer’s disease (AD) research on various topics that were released in November of 2023. In this episode, Anusha takes you through 11 papers testing potential neuroprotective agents for AD treatment. You’ll hear about naturally and ph...

If you’re interested in hearing about the impact of hearing aids on quality of life in AD patients, or how having a stable life partner can slow down the progression of dementia, tune in to this episode on the latest in cognitive and behavioural research in Alzheimer's disease! Judy will cover 9 papers on sleep, depressive symptoms and sensory processing, all published in February 2023. This is on...

In today's episode, Naila provides you with an overview of 10 paper published in February 2023, on non-pharmacological therapies for Alzheimer's disease. You'll learn about a virtual reality intervention targeting anxiety, the signaling pathways underlying the potential benefits of acupuncture, the challenges of implementing new interventions, and what spectral light flicker means. Happy listening...

This short and sweet episode kicks off the February 2023 series, highlighting studies all the way from worms to humans. Anusha will take you through 9 papers that converge on targeting neuroprotection in Alzheimer's disease. If you're interested in learning about implicated pathways or potential therapeutics, this episode is sure to whet your appetite.   Sections in this episode:   Targeting Speci...

Elyn's back with more insight from the field on how blood vessel health impacts brain health. Tune in for a journey through mechanisms underlying increased risk from "vascular risk factors" like hypertension, diabetes, and atrial fibrillation, lots of neuroimaging studies providing clinical insights, and several interesting novel therapeutic avenues. If you weren't already convinced that the vascu...

This episode covers some papers from January 2023 on treatments focused on repairing the neurotransmitter imbalance in Alzheimer's disease. We hope you enjoy listening as Christy summarizes this exciting research—from the discovery of new therapeutics to the synthesis of drugs.  Sections in this episode: Drug Screening (3:37) New Drugs (7:00) Synthesized Drugs (13:35) -----------------------------...

In today’s episode of AMiNDR, Ellen will tell you all about the functional connectivity of different networks in the brain, and changes to brain structure and volume in Alzheimer’s disease. This includes how these changes in the brain relate to cognitive changes, behavioural symptoms, and other neuropathological markers. There are many fascinating studies to hear about today!   Sections in this ep...

Naila covers 11 papers from January 2023, with a focus on a variety of stimulation techniques. You'll get a smattering of new research from humans to mice to flies, and from brain imaging to computer simulations to molecular mechanisms. Enjoy!   Sections in this episode:   Complementary therapies (2:55)   Current and magnetic stimulation (7:25)   Electroacupuncture (14:30)   Other stimulation tech...

We’ve got a whole variety of studies in this January 2023 episode, spanning from sensory processing, to sleep, and even to depressive symptoms. Tune in to learn more about the latest in cognitive and behavioural changes in Alzheimer's disease!   Sections in this episode:   Sensory Processing (2:28)   Sleep (7:30)   Balance (14:14)   Depression (17:00)   Other (20:40)  -----------------------------...

In this episode, we’ll be covering papers that were released in January 2023 that target neuronal and synaptic protection in Alzheimer’s Disease. If you’re interested in the preclinical testing of novel therapeutics and delivery methods, this is the episode for you!   Sections in this episode:   Novel Therapeutics Targeting Neuroprotection (4:53)   Novel Delivery Methods Targeting Neuroprotection...

We are diving in to all things neurotransmitters and synaptic signaling to kick off the January 2023 series. You'll hear about dopamine, noradrenaline, prion proteins, a new 3D cell culture model, and more, in today's episode. Enjoy!   Sections in this episode:   Monoamine Neurotransmitters (3:50)   Glutamate (9:18)   Acetylcholine (15:51)   Synaptic Proteins (17:43)   New 3D Culture Method (21:32...

Welcome our new host, Anelya, who covers 12 papers on the role of immune system and glia in Alzheimer’s disease. The first half of this episode will focus on potential targets for the treatment of Alzheimer’s disease, followed by the disease-associated inflammatory mechanisms. Part 2 will be released as a bibliography. We hope you find this episode interesting!   Sections in this episode:   Potent...

Ellen brings you summaries of 8 abstracts from November 2022, all about functional connectivity and imaging in the context of Alzheimer's disease. There are a variety of brain regions covered in today's episode, including cortical regions, subcortical structures, and the hippocampus. Spanning studies in both humans and animals, this episode is sure to have something of interest to you and your res...

For today's episode, Naila is back to take you through 20 papers on prevention and intervention strategies in Alzheimer's. You'll be treated to the latest on mindfulness and meditation, the default mode network's involvement in Alzheimer's, strategies for assessing and optimizing therapies, stimulation techniques and more. Enjoy!   Sections in this episode:   Innovation assessment (3:08)   Cogniti...

In this episode, Anusha guides you through 11 papers that were published in November of 2022. These papers study the efficacy of treatments targeting neuroprotection in Alzheimer's Disease models. Tune in if you want to be on the cutting edge of drug discovery and development in the field of AD.   Sections in this episode:   Drug Discovery and Development of Novel Therapeutics (3:49)   Testing Exi...

Judy is so excited to take you through part 1 of the behavioural and cognitive changes in AD episode (part 2 will be released as a bibliography). This shorter episode features standard motor symptoms like impaired exercise and grip strength, as well as some less studied behavioural changes such as adverse driving in AD. You don’t want to miss this one!   Sections in this episode:  Behavioural Chan...

Ellen kicks off the November 2022 series with 11 papers about synaptic transmission and neurotransmitters in Alzheimer's disease. Hear about glutamate, acetylcholine, synaptic proteins, and more in this jam-packed episode!   Sections in this episode:   Glutamate and Acetylcholine (4:01)   GABA neurons (10:52)   Neuron Excitability (12:15)   Synaptic Proteins (15:10)   Neuro-Immuno-Endocrine System...

Today, we talk all about neuroimaging, with 7 papers that use various imaging modalities in humans, animals, and computational modeling, to study how the brain changes in Alzheimer’s disease. Tune in to learn more!   Sections in this episode:   Hippocampus (3:50)   Hypothalamus (8:15)   Cortical regions (10:29)   Nucleus basalis (15:57)   Pineal gland (18:40)  -------------------------------------...