AMiNDR: A Month in Neurodegenerative Disease Research

This longer episode features amyloid and tau detection in the brain, as well as new PET targets of AD! Judy discusses papers from January 2021 that include topics such as AD mouse models, deep learning methods and several different PET tracers. Tune in to find out more!     Sections in this episode:   PET (1:54)   Non-PET (32:51)   New PET Targets (35:22)     --------------------------------------...

In Part 2 of mechanisms underlying AD risk factors, you'll learn about comorbidities ranging from traumatic brain injury to schizophrenia, hear a little bit about hearing loss, and be exposed to some research on exposure to toxic metals. Naila is your host for today, and will take you through 13 papers from January 2021!     Sections in this episode:   Comorbidities (2.10)   Noise/Hearing Loss (12...

In this episode, Naila covers the first half of peer-reviewed papers publish in January 2021 on mechanisms underlying risk factors of Alzheimer's disease. In 11 papers, she'll go through diabetes, cardiovascular disease and sleep troubles. Enjoy, and check out Part 2 for more!     Sections in this episode:   Diabetes (1:39)   Cardiovascular (5:22)   Sleep (17:15)  ---------------------------------...

In today’s episode, Marcia brings you the latest research from Jan 2021 on changes to RNA, Transcription and Translation in the context of Alzheimer’s disease. We also talk about some really in-fashion techniques like multi-omics, deconvolution,  mendelian randomization and co-localization. Tune in to learn about these techniques and more!     Sections in this episode:   Multiomics (2 papers) 1:10...

In this episode, Glory will take you through the papers published on alterations to synaptic transmission and structure in Alzheimer's disease from January 2021. Tune in for all things synaptic - including glutamate receptor signalling, long-term potentiation and dendritic spine integrity!  Sections in this episode:   Neurotransmitter signaling: 1.45   Synaptic plasticity: 13.55   Synapse structur...

In this episode, Jacques covers papers from January 2021 on the mechanisms of APP processing in Alzheimer's disease and strategies to alter amyloid-beta production. Learn something new as we explore pathways associated with increased amyloid-beta production, the development of BACE inhibitors and recent clinical trial findings!    ------------------------------------------------------------------ ...

Elyn is back with more on vascular contributions to Alzheimer disease. Tune in to hear about clinical studies connecting the vasculature to the AD pathology, mechanistic studies about amyloid clearance and deposition into cerebral vessels, and much more - all from papers published in January 2021!  Sections in this episode:  Clinical Studies - Connecting the Vasculature to the AD Pathology (3.20) ...

In this episode on epidemiological studies published in January 2021, Naila will take you through a range of risk factors of AD, including cardiovascular disease, diabetes, other comorbidities, environmental factors, and a few protective factors. There’s a lot of information packed into 21 papers, so you’re sure to feel accomplished after!     Sections in this episode:   Prevalence (1:47)   Comorb...

In this episode, Courtney will take you through the papers published on ApoE in Alzheimer's disease from January 2021. The topics covered include the role of ApoE on cognitive function, the impact of ApoE on biomarkers and the molecular mechanisms ApoE impacts.  Be sure to tune in for all things ApoE!!   Sections in this episode:   Cognitive Function (2.00)   Impact of ApoE on Biomarkers (9.43)  M...

In the first episode of our January 2021 series, Anusha will be guiding you through papers that traverse topics within neuroprotection in AD models, including therapies that target A-beta toxicity, glutamate excito-toxicity, and novel therapeutic approaches. We hope you get excited - within reason!     Sections in this episode:   Amyloid-beta toxicity and glutamate excito-toxicity (2:03)   Novel t...

In this episode, Courtney covers Part 2 of the papers published in September of 2020 on cognitive testing as a diagnostic tool. The topics in this part cover a wide array of topics including brain wave techniques, gait analysis, facial recognition, neuropsychiatric symptoms, and finally cognitive testing.     Sections:   1:56 Brain wave studies in Dementia (2 papers)   4:23 Gait (2 papers)   7:16...

This shorter episode on metabolic changes and hemodynamics covers a wide range of neuroimaging techniques, including FDG PET, MRI and CT. Judy will discuss the applications of these modalities in deep learning, AD diagnosis and more. Definitely worth a listen if you’re into neuroimaging!     Sections in this episode:   FTG PET papers - 1:02   MRI papers - 9:40  ------------------------------------...

This episode covers recent papers that explore the underlying mechanisms of both protective and risk factors of Alzheimer’s disease. You’ll hear a little about how education, exercise and diet might reduce the risk of cognitive decline later in life, and a lot about the physiological and biochemical factors underlying high fat diets, diabetes, cardiovascular disease and exposure to environmental p...

This episode, hosted by Naila, covers papers published in September 2020 that use cognitive testing as a diagnostic tool. These studies vary from validating and comparing existing tests, to refining them for specific applications, to correlating cognition with AD biomarkers. You’ll learn a bit about the variety of cognitive tests used, and how researchers are constantly building on existing tools...

In this episode, Marcia will cover papers published in Sept 2020 on treatment development for AD with special focus on the tau protein. She discusses tau in its role as a microtubule-associated protein and the related use of microtubule-stabilizing agents in treating AD. She also talks about papers on immunotherapy, autophagy, and inhibiting tau hyperphosphorylation. Tune in to hear about all of t...

Can you believe this is our 100th episode??? It has been a little over 6 months since our official launch and we are now running full steam, thanks to a hardworking team. Cheers to the members of AMiNDR, and cheers to you for listening to us.  This episode is for those of you who are interested in what’s already on the marker for treating Alzheimer’s diseases. That’s right, you have knowingly or b...

Alyssa will cover tau protein expression, aggregation, and pathology in Alzheimer’s Disease from studies published in Sept 2020. This episode will dive into papers that examine genetic mutations, toxin exposure and protein interactions that lead to tau pathology and identify potential future therapeutic targets to treat these diseases. A quickie but a goodie if learning more about tau protein is y...

In this episode, Elyn caps off the papers on Cerebrovascular Changes in AD from September 2020. There’s mounting evidence for a significant overlap between vascular disease and brain health, and Elyn dives into the newest papers exploring this relationship. Tune in to hear about how cerebral small vessel disease might be the mediator between arteriosclerosis and cognitive impairment, how APOE is r...

In part 2 of this series, Bhumika continues the deep dive into imaging papers from September 2020 focusing on structural changes and connectivity of the brain, and subsequent white matter changes. Enjoy the episode and tune in to part 1 if you're interested in hearing about more new studies on this topic!  ------------------------------------------------------------------   To receive the list of...

In today's episode, Glory updates you on the latest studies from September 2020 on changes to RNA, transcription, and translation mechanisms that may contribute to Alzheimer's disease pathology. Enjoy!     Sections in this episode:   ncRNAs: 1:37   Histone acetylation: 9:55   -Omics: 14:44   Other: 24:52  ------------------------------------------------------------------  To receive the list of pa...

In this half-hour episode, Judy goes through September 2020 papers that look at diagnosing or characterizing Alzheimer's disease based on the detection of the proteins amyloid and tau in the brain and other structures. Topics include conventional and novel neuroimaging techniques, deep learning methods and retinal amyloid-beta. Tune in to find out more!     Sections in this episode:     PET   Deep...

Bhumika updates you on the latest papers on brain imaging of structural changes and connectivity in AD! This includes MRI and PET imaging to characterize or diagnosis this disease, as well as new machine learning technology, and more! Enjoy, and look out for part 2 soon!  ------------------------------------------------------------------   To receive the list of papers covered, please fill this fo...

Courtney is back with Part 2 of Inflammation, Glial Cells and TREM2 papers published in September of 2020! If you haven't already, check out Part 1 in episode #91. In this exciting sequel, she discusses methods to study inflammation, astrocytes in inflammation and peripheral immunity.  ------------------------------------------------------------------   To receive the list of papers covered, pleas...

Elyn is back with more on fluid biomarkers for Alzheimer’s Disease from September 2020 papers. Here, she covers new candidate biomarkers including panels of lipids, soluble TREM2, and methylation sites on known risk genes. She also dives into insight into APOE4 mechanisms revealed by biomarkers, the stark overlap between vascular dementia and Alzheimer’s disease, and much more. This is a long one,...

Courtney updates you on all the new publications from September 2020 about inflammation, glial cells, and TREM2, in the context of Alzheimer's disease. There were a lot of papers on these topics, so we split it up into 2 episodes. Stay tuned for part 2 coming soon!  ------------------------------------------------------------------   To receive the list of papers covered, please fill this form:  ...