AMiNDR: A Month in Neurodegenerative Disease Research

Is the ever-expanding genetic landscape of Alzheimer’s disease overwhelming for you? Joseph will help you catch up on all the literature about new genes or variants linked to Alzheimer’s Disease in September 2020.  Sections in this episode:   Novel Gene Discovery - 1:08   New Variant Discovery - 10:24   Testing Associations in Novel Genes - 13:50   Miscellaneous - 18:33  --------------------------...

In this episode, Marcia updates you on 8 papers from September 2020 on the development of treatments that target amyloid-beta mediated toxicity to treat Alzheimer's disease. Tune in to hear more!  ------------------------------------------------------------------   To receive the list of papers covered, please fill this form:   -------->  https://forms.gle/CVVbznAFM8pamdgk6  -------   or by tweeti...

In today’s episode, you’ll hear about the latest developments in preventing or treating AD using non-pharmacological approaches, such as cognitive interventions, stimulation techniques, and exercise. Naila covers clinical trials in humans and mechanistic studies in animal models, all in 19 papers. Enjoy!   ------------------------------------------------------------------   To receive the list of...

Interested in the behavioural aspects of AD such as changes to cognition, emotion, sleep, sensory and verbal abilities, and learning and memory? Look no further. Anusha will guide you through the literature that was published on these topics in September (2020) to help you start the new year off on the right foot.     Sections in this episode:   1.47 Cognition/Emotional Processing/Depression   10....

Happy New Year from the AMiNDR team! In our first episode of 2021, Abdullah presents on the modulation of inflammatory response in AD, with a big emphasis on microglia, the forgotten heroes in his mind, they clean, repair and protect your brain. Hopefully by the end of the episode you’ll know more about why changing their behaviour could be the treatment we are looking for.     Sections in this ep...

Interested in the mission to accurately diagnose Alzheimer’s disease with a blood test? This episode is perfect for you. In this two-part episode on Fluid Biomarkers in AD from September 2020 papers, Elyn explains the ATN framework for AD diagnosis, and covers papers focused on fluid biomarkers relating to amyloid, tau, and neurodegeneration. She also touches on a few new methods for biomarkers re...

In this episode, Jacques will tell you about new peer-reviewed publications from September 2020 on mechanisms of APP processing and protein aggregation in the context of Alzheimer's disease. This includes aggregation of amyloid-beta as well as other proteins such as tau and alpha-synuclein. Enjoy the episode!  ------------------------------------------------------------------   To receive the list...

In this episode, Marcia covers papers published in September 2020 that focus on the latest in novel drug development in AD. We especially talk about papers targeting amyloid-beta aggregation, BACE-1 inhibitors, gamma-secretase, immunotherapy for AD and more! Tune in to learn more.  5:46 - BACE-1  9:09 - Gamma secretase 11:12 - More papers on amyloid-beta aggregation -------------------------------...

Is your research on diet and nutrition and Alzheimer’s disease? Or maybe you are diving deeper into the role of carbs and fat metabolism, and are interested in mitochondrial function in neurodegenerative diseases? Then stay here! Sarah covers 13 papers from our September 2020 harvest with topics ranging from the ketogenic diet to the lipidome.     List of sections: Diet and nutrition: 2.18 Carbohy...

Elyn is back to cover the latest findings relating to the cerebrovasculature in Alzheimer disease! In this two part episode covering papers from September 2020, you’ll hear about how aging and systemic inflammation can influence the blood-brain barrier, how circulating “good cholesterol” can protect the blood vessels and may be dysfunctional in AD, and a whole lot about cerebral small vessel disea...

In this episode, Courtney will update you on papers published in September 2020 on the Disease Mechanisms of ApoE. You will hear about cognitive impacts of ApoE, ethnic variability in ApoE, Neuroimaging of ApoE isoforms, and even some additional genetic implications of ApoE. List of Sections: Impact on Cognitive Abilities:  3.00 Ethnic Variability Behind ApoE Isoforms: 14.17 Neuroimaging with ApoE...

If you can’t quite decide which episode to listen to, maybe give this one a try. We’re covering preclinical models of AD as it pertains to mitochondria, autophagy, metabolism, behaviour, and much much more. Join Anusha so she doesn’t have to explore all these exciting papers all by herself!   List of Sections: Mitochondria:  1.31 Autophagy/Metabolism: 5.34 Behaviour: 12.12 Other: 23.07 -----------...

This episode is the second half of a two part series covering papers published in September 2020 on treatment approaches with multiple targets for Alzheimer’s disease. For part 1 of this series, check out episode 74! In this part, we’ll take a look at papers targeting many different AD processes, including oxidative stress, cholinesterase activity, and amyloid beta formation. The final paper in th...

You'll hear about how mechanisms of oxidative stress, autophagy and the gut microbiome may contribute to AD pathology, as Abdullah updates you on the new papers from September 2020 on these topics. Enjoy!  Sections in this episode:  Oxidative stress (6) 2:15 Autophagy (2) 13:52 Gut microbiome (1) 19:53 ------------------------------------------------------------------  To receive the list of paper...

In this episode, Judy goes over papers published in September 2020 that focus on sex differences in Alzheimer’s disease. We also cover a few papers that did not quite fit into our other genetics-themed episodes, including AD-related stigma, lewy body dementia and overlapping risk factors of AD and Parkinson’s disease. Tune in to learn more!  Sections in this episode:  APOE 1:10  Female-specific AD...

Naila is back to round off the non-genetic risk factors for September, with 6 papers on a variety of potential comorbidities, and 7 more on epidemiological studies and the interaction of various modifiable risk factors. We cover a lot of ground and geographic locations this episode, so buckle in for a solid - but hopefully riveting - half hour of information!  -------------------------------------...

In this episode, Alex will be covering papers published in September 2020 within the category of novel drug development, that focus on multi-targeted approaches to Alzheimer’s disease treatment. We’ll take a look at papers targeting many different AD processes, including oxidative stress, cholinesterase activity, and amyloid beta formation. Part 2 will be coming out shortly!  ---------------------...

In this episode, Naila goes through 13 papers that explore how benzodiazepine and anticholinergic drug use affect individuals with dementia, whether exposure to certain air pollutants increase the risk of AD, and how cognitive reserve - whether in the form of occupation, bilingualism or education - may protect against cognitive decline. Enjoy!   ----------------------------------------------------...

What is it about neurotransmission that is so difficult to regulate in Alzheimer's? Anusha will tell you in this episode, so tune in if you're interested in the role of cholinergic and glutamatergic transmission, or the role of the hippocampus in AD.    ------------------------------------------------------------------  To receive the list of papers covered, please fill this form:   -------->  htt...

This episode, hosted by Jacques, explores many facets of amyloid-beta mediated toxicity. First, we run through the structure-toxicity relationships of mutant amyloid-beta. Second, we investigate the interaction of amyloid-beta oligomers with membranes and their effect on vesicular trafficking and endocytosis. And lastly, we finish the episode on insights into the effects of amyloid-beta on neurotr...

In the first of 3 episodes on AD risk factors for September 2020, Naila covers some of the most studied (arguably) modifiable risk factors, including diet, exercise and sleep. You'll also hear about the effects of hormones and common comorbidities such as diabetes and cardiovascular disease. As many of these factors relate to one another, this will give you a good overview of the literature on com...

Are you invested in the role of neurotransmission in Alzheimer’s disease? Well then buckle in because in this episode, Anusha will go over the latest and greatest compounds that target disease state changes to synaptic transmission in animal and in vitro models of Alzheimer’s. This episode covers the papers published in September of 2020 that use animal models and tissue culture to test the effect...

Sarah and Elyn are joined by Kyle and Drake from BrainBuzz Podcast to share our journey, growth, and challenges with starting a podcast for science communication in Psychology for them, and Neuroscience for us.  What is it like to talk about our research at cocktail parties? What does starting a podcast require? How does one manage to say "neurodegenerative" without stuttering?   This is the secon...

In this episode, Elyn takes you through a very diverse set of papers on Alzheimer’s disease mechanisms - catching all of the papers that didn’t slot nicely into other episodes. The topics span a wide range from how the reflex of your pupils adjusting to light may be an early indicator of AD, to potentially pathogenic crystals in post-mortem AD brain tissue. There are also several RNA-based papers...

Today’s episode is on protein expression, aggregation, misfolding and pathology, with an emphasis on tau pathology in Alzheimer’s Disease and we are rounding off the papers published in August 2020. If you are interested in tau spreading in neurodegenerative disease, protein dysfunction in disease and new potential therapeutic targets, Alyssa has got you covered.  ---------------------------------...