AMiNDR: A Month in Neurodegenerative Disease Research

Discover the latest on risk and protective factors of AD, from the perspective of 18 observational studies published in December 2021. Naila will take you through socioeconomic factors, nutrition, exercise, and various comorbidities related to AD.   Sections in this episode:   Prevalence and Socioeconomic Factors (1:45)   Nutrition (13:11)   Health-Related Factors (18:49)  ------------------------...

In this short and sweet episode, Anusha will take you through 7 papers published in December of 2021 on the subject of treatments targeting neuronal and synaptic protection in AD. Exercise your cognitive reserve by tuning into this episode!   Sections in this episode:   Testing Naturally-Derived Compounds (3.35)   Testing Pre-Existing Drugs (10.54)  ------------------------------------------------...

Tickled by tau? Preoccupied with post-translational modifications? Join Kate as she covers the latest papers published in December 2021 on tau protein pathology and targeting tau as a therapeutic strategy in Alzheimer's disease.   Sections in this episode:   Tau Aggregation & Post-Translational Modifications (3:19)   Generalized Tau Pathology & Tau Seeding (7:29)   Treatments Targeting Tau in AD (...

Tired of the amyloid cascade hypothesis? Think there's more to AD than the plaques and tangles? You've come to the right place! Elyn is back for her final episode covering papers from 2021 on Vascular Contributions to Alzheimer Disease. Tune in to hear about the latest findings relating to cerebrovascular changes in AD, and why they matter.   Sections in this episode:   Insights from Clinical Stud...

In today's episode, Naila will take you through 11 studies from December 2021 on different non-pharmacological methods for treating Alzheimer's disease. You'll hear the latest research on the importance of sleep, how cognitive training might reduce Alzheimer's pathology, and numerous stimulation techniques for improving cognitive function in people with AD. Enjoy!   Sections in this episode:  Cogn...

This episode of AMiNDR is part 2 of our Clinical Assessment series. Today, you'll hear about new cognitive tests and advancements in existing tools for clinical testing. With every new study on Alzheimer’s disease, we are one step closer to understanding this disease better, diagnosing people faster, and helping people more effectively. Get ready to hear about some of the latest ways that scientis...

Can smell, gaze, blinking rate, or handwriting offer a window into what happens inside the Alzheimer’s disease brain? Are there parameters we can add to our batteries for assessing cognitive decline in a clinical setting? Missed opportunities in cognitive assessment? Maybe. This episode is dedicated to all kinds of variables that can help orient ourselves on the Alzheimer’s disease continuum, and...

Could changes to synaptic transmission underlie Alzheimer's disease pathology? Anusha has 8 papers to help you answer that question. These papers assess changes in humans, human models, and animal models and were all published in December of 2021.   Sections in this episode:   Changes in Neuronal Activity in Humans and Human Models (2.50)   Changes in Neurogenesis in APP/PS1 Transgenic AD Mice (10...

To kick off this series, Ellen tells you about 17 studies published in December 2021 on how different forms of cognition, sensory processing, and psychiatric health can be affected in Alzheimer's disease, as well as papers exploring new treatment options! If you are an Alzheimer's researcher, or are just interested in hearing about the latest progress in this field, you don't want to miss this epi...

Naila's back with 19 epidemiological and observational studies published in November 2021. It's quite the panoply of topics - you'll hear about marital status, air pollution, metabolic syndrome, medication use and more. We hope you enjoy!   Sections in this episode:   Epidemiological and Environmental (1.44)   Vaccine/Medication Use (15.10)   Psychomotor (22.48)   Metabolic Comorbidities (26.18)  ...

Tired of only hearing about tau or a-beta when it comes to AD research? Take a peek behind the scenes with Kate to explore the latest on the proteostasis and autophagy pathways that work to safeguard our cells in 13 papers from November 2021.   Sections in this episode:   Autophagy & Proteostasis Pathology (4:17)   Targeting Proteostasis/Autophagy Machinery (22:21)  -------------------------------...

17 papers have "Targeting neurotransmission and synaptic dysfunction in AD" written all over it. Figuratively speaking of course. Anusha covers topics like targeting neurotoxicity and calcium flux, or acetylcholine transmission and balance, or even targeting monoamine oxidases to improve AD-like pathology. Better yet, this episode lets you keep up to date as all the papers were published in Novemb...

Join Kate for a comprehensive summary of everything tau from papers published in November 2021.  We'll talk post-translational modifications, prion-like seeding pathology, molecular modeling, and even touch on a potential AD therapies targeting this fascinating little microtubule helper. Enjoy! :)   Sections in this episode:   Tau Aggregation and Post-Translational Modifications (03:03)   Tau Seed...

Interested in a fresh perspective on the etiology of AD? Join Elyn for her monthly tour through the new research on vascular contributions to Alzheimer disease! Whether this is your niche field, or you want to look at the disease through a new lens, this episode is perfect for you. Tune in to hear about endothelial cell biology, a phase 2 clinical trial, and several animal models!   Sections in th...

Welcome all researchers, students, and clinicians who are interested in learning about clinical testing for Alzheimer’s disease! This episode is dedicated to papers published back in November 2021 on new and old assessment methods to help in the diagnosis of Alzheimer’s. This includes testing cognitive processes and performance on activities of daily living, detecting Alzheimer’s, and distinguishi...

In today's episode, Naila will guide you through 10 papers that were published in November 2021 on preventing and treating Alzheimer's disease. You'll hear about snoring, caffeine consumption, the mechanisms underlying exercise, and a bunch of neuromodulatory techniques that could treat certain aspects of AD. Hopefully you'll find this latest research to be stimulating!   Sections in this episode:...

You have just entered the magical world of Alzheimer’s literature. You are about to experience 8 papers that do their best to better understand the changes in synaptic transmission in Alzheimer’s disease. Where did we find such curious abstracts you ask? It just so happens that these were all papers published in November of 2021. Ready to go? Close your eyes and let Anusha be your guide through th...

To kick off the November 2021 series, Ellen brings you 11 papers published this past November on the topic of Alzheimer's disease and dementia. Tune in to hear about research on chronic stress, sleep quality, and an active compound from the cannabis plant that could be used to treat AD symptoms! That's just a taste of what you'll hear about in this episode that covers a diverse array of research a...

In this special episode of AMiNDR, where we sit down with Jenn Kim and Lucy Aceves, two of the creators of the graduate student-run Neuropsyched Magazine! We talk all things graduate school and academia --  from useful tips for choosing a PI, our experiences of grad school during the pandemic, financial barriers we have faced, and establishing boundaries. We also tell you about Neuropsyched magazi...

Naila is back for part 2, to take you through epidemiological studies on lifestyle factors and comorbidities related to Alzheimer's disease. In today's episode, you'll learn about dietary factors, the association between hair loss and AD, and even a little about Covid-19 (sorry!). Lots to learn in just 13 papers!   Sections in this episode:   Lifestyle factors (1:39)   Nutrition (7:08)   Physical...

In Part 1 of our episode on epidemiological studies from October 2021, Naila will cover 11 papers on demographic and socioeconomic factors related to dementia and Alzheimer's disease. You'll hear a lot on subjective cognitive decline, education and occupation. Enjoy, and be sure to check out Part 2!   Sections in this episode:   Prevalence and Demographics (1:33)   Education (7:51)   Socioeconomic...

Thinking about thinking? Changes to synaptic transmission contribute to Alzheimer's disease pathology. Hear all about 10 papers published in October of 2021 exploring synaptic dysfunction in AD from Anusha who hosts this episode.   Sections in this episode:   Synaptic dysfunction in rodent AD models (2.58)   Synaptic dysfunction in other AD models & human studies (16.41)  -------------------------...

Elyn is back with your monthly update on vascular contributions to Alzheimer disease! This month she covers 8 papers that primarily focus on the blood-brain barrier, and white matter hyperintensities that reflect cerebrovascular abnormalities. Tune in for some exciting new findings in the field and more data emphasizing the importance of vascular health in dementia.   Sections in this episode:   W...

New year, new papers! Join Kate for your monthly update on all things proteostasis and autophagy as they relate to both AD pathology and potential new therapeutic interventions. In today's papers, we'll journey through the endolysosomal system, say "Hi" to some new chaperone families, and even discuss the interplay between AD and other distinct neurodegenerative diseases. Enjoy!   Sections in this...

Welcome to our first episode of 2022! Marcia will bring you 13 genetics papers from October 2021. We will talk about all kinds of topics - right from AD-associated loci to polygenetic risk stratification, all of which can contribute to planning effective treatment strategies. Tune in!   Sections in this episode:   Transcriptomics/Gene Expression Changes (2:33)   Genetic Variants (6:16)   Genetic R...