AMiNDR: A Month in Neurodegenerative Disease Research

Join Marcia for Part 1 of this genetics episode covering a total of 13 papers. In this one, she talks about papers from October 2021, related to transcriptomics, especially genes that are differentially expressed In Alzheimer’s disease, and some studies with vertebrate and invertebrate AD model organisms and risk loci. Tune in to learn more!  Sections in this episode:   Transcriptomics/Gene expres...

Hello there! Just in time for the holiday season we've got quite the deal lined up for you. Two episodes for the length of one! Anusha will be guiding you through the literature of October 2021 that focuses on targeting neuronal function and neurotransmission as an Alzheimer's disease treatment. If you want to find out the progress we've been making as a field towards finding better treatments, th...

We've got a short and sweet episode for you today, with 7 papers from October 2021 on the intervention and prevention of AD. Tune in to hear Naila ramble on about pet therapy, update you on diet and exercise research in animal models, and provide a stimulating overview of neuromodulatory techniques.   Sections in this episode:   Complimentary Therapies (2:55)   Lifestyle Interventions (9:30)   Sti...

We have 14 papers in this episode using structural magnetic resonance imaging (sMRI) in the diagnosis or prognosis of Alzheimer's Disease. Join Christy as she walks you through some deep learning based frameworks and other automated models, as well as new findings with grey matter atrophy.   Sections in this episode:   Deep Learning (2:38)   Automated Algorithms & Models (8:24)   Grey Matter (17:2...

Kate lets you know what's going on in the world of tau protein research in this episode of AMiNDR! Tune in to hear all about tau seeding, tau pathology, and potential therapeutic interventions for Alzheimer's Disease that target this protein. Enjoy!   Sections in this episode:   Tau seeding-related pathology (3:40)   Targeting tau for therapeutic interventions in AD (14:35)  ----------------------...

To kick off our series on papers published in October 2021, we'll look at 7 papers that rely on Positron Emission Tomography (or PET) imaging to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, m...

Feeling like we're beating a dead horse with the amyloid cascade hypothesis? Think there's an X-factor to Alzheimer disease that is tied to both the clinical symptoms and the plaques? Could be the vasculature! Elyn is back to take you through the 12 papers published on vascular contributions to Alzheimer disease, and hopefully get you excited about this blossoming line of research and the new trea...

Were you looking to learn about clinical testing for Alzheimer’s disease? This is Part 2 of our monthly episode on cognitive and clinical markers for diagnostic and prognostic purposes. Come learn about tests for psychomotor, visuospatial and motor abilities, as well as genetic screens for detecting AD. You will also learn about new cognitive tests for for distinguishing AD from other dementias, o...

You may have come across a variety of exams used to test cognitive function and assess cognitive decline, such as the Addenbrooke's Cognitive Examination, the mini mental state exam, the clock drawing test, and many more. So how are we doing with these? And how well do they apply in special populations such as people with intellectual disability? Is there room for racial bias in how they are admin...

This episode is short and sweet, covering 7 papers on cognitive training, exercise and stimulation techniques. Naila will guide you through the latest in animal models and underlying mechanisms for these potential non-pharmacological interventions.    Sections in this episode: Cognitive Training (2:06)  Exercise (4:23)  Stimulation Techniques (11:38) -----------------------------------------------...

Ellen tells you about research on topics such as cognitive reserve, reinforcement learning, psychiatric conditions, sleep issues, speech,  and more in this jam-packed episode on cognitive and behavioural changes in Alzheimer's Disease.  Sections in this episode:  General Cognition (3:32)  Reinforcement Learning (14:09)  Speech and Language (16:33)  Visuospatial and Motor Control (25:06)  Psychiatr...

Back for part 2, Naila takes you through 15 papers pertaining to health conditions associated with AD and dementia. You'll hear about infections, cardiovascular and metabolic risk factors, and a few miscellaneous diseases.   Sections in this episode:   Epidemiology / Multiple Factors (1:00)   Immune Conditions (8:00)   Metabolic and Cardiovascular (15:00)   Neurological Comorbidities (24:50)  ----...

In today's episode, Naila takes you through 10 papers on risk factors associated with Mild Cognitive Impairment, Alzheimer's and dementia. You'll hear a little on lifestyle factors, air and noise pollutants, and hormones. Stay tuned for Part 2!   Sections in this episode:   Lifestyle & Environmental Factors (2:09)   Hormones (15:13)  -------------------------------------------------------------- ...

Join Glory to learn about the newest genetic variants and mechanisms that have been linked to Alzheimer's disease. In this episode, we'll cover protective and pathogenic AD variants in genes, potential genetic biomarkers for AD, and differential gene expression that can be observed in individuals with AD. With 19 papers from September 2021, you'll hear about some genes that will be worth following...

Tune into this month's episode on the latest research on autophagy and proteostasis in Alzheimer's Disease. This includes papers on how autophagy and protein homeostasis are dysfunctional in this disease, and potential treatments that target these cellular pathways. Enjoy!   Sections in this episode:   Proteostatic and autophagic dysregulation (4:33)   RNA splicing, binding, and signaling (10:32)...

Let’s take a trip with Vee through the latest literature to the mitochondria and learn about oxidative stress, metabolism and related therapeutics in Alzheimer’s disease pathology. A jam packed session from vitamins to energy homeostasis to metal chelators- this episode has it all! We have 10 publications from September 2021, which will surely “power” your interest. Tune in and get ready to charge...

Let's take a closer look at 18 papers published in September 2021 that rely on positron emission tomography (or PET) to detect amyloid and tau pathology in the brain, within the context of Alzheimer's disease! If you're interested in learning about tau and amyloid based detection, alternative PET tracers in AD research, or combining PET with different imaging modalities, make sure to tune into thi...

Tired of untangling the tricky world of tau literature all on your own? Interested in the mechanisms of tau pathology, therapeutic advancements targeting tau, or both? Join Kate for another exciting episode covering 20 new papers published in September 2021. We’ll explore tau aggregation, regulation, and treatment development through a wide variety of model systems, from molecular dynamics all the...

18 papers published in September of 2021 await you. What do they all have in common? They explore treatments for Alzheimer's disease that all target neurotransmission. If you're interested in restoring acetylcholine balance or other treatments that also improve cognitive function in Alzheimer's disease, tune in to hear Anusha take you through the literature.   Sections in this episode:   Discovery...

Are you interested in neuronal hyperexcitability, impairments in synaptic plasticity, and interactions between amyloid plaques and synaptic proteins in Alzheimer's disease pathology? You've come to the right podcast! In this episode, Glory will guide you through 11 publications from September 2021 on the latest research about the mechanisms of synaptic transmission and plasticity that contribute t...

The first episode of our September 2021 series gets us acclimated with papers that target neuronal and synaptic function in preclinical studies of Azheimer's disease. Join Anusha and she walks you through papers that explore topics like rescuing amyloid beta-induced toxicity, restoring neuronal morphology, and using animal models of Alzheimer's disease to target neuronal function.  Sections in thi...

This is part 2 of our episode on clinical markers for Alzheimer’s disease, where we cover papers published in August 2021. How does a translation of your favourite cognitive test perform in a Chinese, Slovenian or Persian population? What measures are we currently ignoring but should be include in our battery of tests to detect Alzheimer’s disease or mild cognitive impairment? There is new stuff o...

Do you want to brush up on your knowledge of MoCA, ADAS-Cog, the MMSE and other cognitive tests? Join Sarah to hear about the 7 papers published in August 2021 where we’re evaluating existing tests for their specificity and sensitivity in detecting Alzheimer's disease and mild cognitive impairment.    --------------------------------------------------------------  You can find the numbered bibliog...

In today's episode of AMiNDR, we’ll be talking about the latest work on cognitive and behavioural changes in Alzheimer's Disease, including papers on executive functioning, depression, social impairments, motor coordination, and more. Join Ellen as she guides you through 18 papers on the mechanisms behind cognition and other neuropsychological symptoms in AD!   Sections in this episode:   Cognitiv...

Are you familiar with protein aggregation in Alzheimer's disease, but want to learn more about the mechanisms cells use to fight back against these stubborn species? Join Kate in exploring the landscape of cellular processes governing proteostasis and autophagy as they relate to AD. In this short-but-sweet episode, we'll cover a total of 7 papers focused on AD pathology involving autophagy and/or...